YRC Public Data Repository - Protein Structure Prediction

Protein:	SRP1
Organism:	Saccharomyces cerevisiae
Length:	542 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRP1.

Description	E-value	Query Range	Subject Range
IMA1_YEAST - Importin subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRP1 PE=1 SV=1 SRP1 - Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear p... gi\|207341840 - gi\|207341840\|gb\|EDZ69787.1\| YNL189Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190409168 - gi\|190409168\|gb\|EDV12433.1\| importin alpha subunit [Saccharomyces cerevisiae RM11-1a] gi\|151944352 - gi\|151944352\|gb\|EDN62630.1\| karyopherin alpha [Saccharomyces cerevisiae YJM789]	0.0	[1..542]	[1..542]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[1..542]	[1..541]
gi\|2959324, gi\|2... - gi\|2959324\|emb\|CAA75513.1\| Importin alpha-like protein [Arabidopsis thaliana], pir\|\|T52102 probable ...	0.0	[3..542]	[2..532]
gi\|18448958 - gi\|18448958\|gb\|AAL69976.1\|AF465210_1 karyopherin alpha [Emericella nidulans] KAPA_EMENI - Importin subunit alpha OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /...	0.0	[9..541]	[2..542]
gi\|85098694 - gi\|85098694\|ref\|XP_960652.1\| importin alpha subunit [Neurospora crassa OR74A] gi\|32412524, gi\|... - gi\|32412524\|ref\|XP_326742.1\| probable importin alpha SRP1 [MIPS] [Neurospora crassa], gi\|28922164\|gb...	0.0	[11..541]	[4..538]

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Predicted Domain #1

Region A:
Residues: [1-62]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNGTDSSTS KFVPEYRRTN FKNKGRFSAD ELRRRRDTQQ VELRKAKRDE ALAKRRNFIP  60
   61 PT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.69897
Match:	1qgkB_
Description:	STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
nuclear export signal receptor activity	3.48172991171337	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
actin binding	2.8014924948341	bayes_pls_golite062009
nucleic acid binding	2.74745843355294	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
DNA binding	1.95242774903625	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
molecular transducer activity	1.32874350341969	bayes_pls_golite062009
signal transducer activity	1.32874350341969	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
transcription factor activity	1.20660383756339	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
structural molecule activity	0.279926218252647	bayes_pls_golite062009
importin-alpha export receptor activity	0.259676026705859	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [63-205]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGADSDEEDE SSVSADQQFY SQLQQELPQM TQQLNSDDMQ EQLSATVKFR QILSREHRPP  60
   61 IDVVIQAGVV PRLVEFMREN QPEMLQLEAA WALTNIASGT SAQTKVVVDA DAVPLFIQLL 120
  121 YTGSVEVKEQ AIWALGNVAG DST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10107.0
Match:	1bk5A_
Description:	Karyopherin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [206-372]

      1          11         21         31         41         51         
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    1 DYRDYVLQCN AMEPILGLFN SNKPSLIRTA TWTLSNLCRG KKPQPDWSVV SQALPTLAKL  60
   61 IYSMDTETLV DACWAISYLS DGPQEAIQAV IDVRIPKRLV ELLSHESTLV QTPALRAVGN 120
  121 IVTGNDLQTQ VVINAGVLPA LRLLLSSPKE NIKKEACWTI SNITAGN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10107.0
Match:	1bk5A_
Description:	Karyopherin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [373-542]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEQIQAVIDA NLIPPLVKLL EVAEYKTKKE ACWAISNASS GGLQRPDIIR YLVSQGCIKP  60
   61 LCDLLEIADN RIIEVTLDAL ENILKMGEAD KEARGLNINE NADFIEKAGG MEKIFNCQQN 120
  121 ENDKIYEKAY KIIETYFGEE EDAVDETMAP QNAGNTFGFG SNVNQQFNFN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10107.0
Match:	1bk5A_
Description:	Karyopherin alpha
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: