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View Structure Prediction Details

Protein: ALF1
Organism: Saccharomyces cerevisiae
Length: 254 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALF1.

Description E-value Query
Range
Subject
Range
TBCB_YEAST - Tubulin-specific chaperone B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALF1 PE=1 S...
ALF1 - Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic m...
gi|190409134 - gi|190409134|gb|EDV12399.1| tubulin folding cofactor B [Saccharomyces cerevisiae RM11-1a]
2.0E-70 [1..254] [1..254]
TBCB_MOUSE - Tubulin-folding cofactor B OS=Mus musculus GN=Tbcb PE=1 SV=2
4.0E-66 [2..244] [11..244]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-57 [2..254] [4..240]
ALP11_SCHPO - Cell polarity protein alp11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=alp11 PE=1 SV=...
alp11 - tubulin specific chaperone cofactor B
1.0E-54 [2..238] [4..229]
CLIP3 - CAP-GLY domain containing linker protein 3
2.0E-54 [17..245] [283..502]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRVVIESEL VRTEKELPNS LKLRQFKDRL YHVTGVEPED MEIVVKRQYD NKEIYSTKKG  60
   61 GAYSNEDEDA NFLKGEEELI VVVTDSNAQS ISNQLATQAE GIPSMEVISE EDYLRRDQSV 120
  121 LRWKMAHGYG RFNAAQQSQR AA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.19381585790185 bayes_pls_golite062009
protein binding 1.17197911794381 bayes_pls_golite062009
structural constituent of ribosome 0.599634454232833 bayes_pls_golite062009
structural molecule activity 0.576819726104993 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [143-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAKQDEAYAR EQLTAAIGRH CRVTVDGSAP REAILRYVGP LPLDVMGTWC GVEFPEAAGK  60
   61 NDGRINGVTL FGPVAPGHGS FVRPRAVEIL SKDEESAEVE DVHDDVESDD EI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.221849
Match: 1lplA_
Description: Cytoskeleton-associated protein F53F4.3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
tubulin binding 2.81573953488242 bayes_pls_golite062009
microtubule binding 2.67824962486294 bayes_pls_golite062009
binding 2.07863891614262 bayes_pls_golite062009
cytoskeletal protein binding 1.95334135428526 bayes_pls_golite062009
microtubule plus-end binding 1.16043967945651 bayes_pls_golite062009
protein binding 0.896264971703612 bayes_pls_golite062009
nucleic acid binding 0.625661567957308 bayes_pls_golite062009
DNA binding 0.336599045092266 bayes_pls_golite062009
transcription regulator activity 0.292990934444865 bayes_pls_golite062009
catalytic activity 0.069855517589921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle