YRC Public Data Repository - Protein Structure Prediction

Protein:	KRE33
Organism:	Saccharomyces cerevisiae
Length:	1056 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KRE33.

Description	E-value	Query Range	Subject Range
gi\|10433597, gi\|... - gi\|13399322\|ref\|NP_078938.1\| N-acetyltransferase 10 [Homo sapiens], gi\|10433597\|dbj\|BAB13995.1\| unna...	0.0	[1..1056]	[1..1010]
U202B_ARATH, U20... - (Q9M2Q4) Hypothetical UPF0202 protein At3g57940, UPF0202 protein At3g57940 - Arabidopsis thaliana (M...	0.0	[3..1006]	[2..971]
NAT10_SCHPO - RNA cytidine acetyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nat10 PE=1 ... SPAC20G8.09c - N-acetyltransferase Nat10	0.0	[1..1053]	[1..1030]
CE11131 - status:Partially_confirmed UniProt:O01757 protein_id:AAB54126.1	0.0	[3..1041]	[2..1025]
NAT10_YEAST - RNA cytidine acetyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NAT10 PE=... KRE33 - Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows...	0.0	[1..1056]	[1..1056]

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Predicted Domain #1

Region A:
Residues: [1-101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKKAIDSRI PSLIRNGVQT KQRSIFVIVG DRARNQLPNL HYLMMSADLK MNKSVLWAYK  60
   61 KKLLGFTSHR KKRENKIKKE IKRGTREVNE MDPFESFISN Q

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [102-720]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIRYVYYKES EKILGNTYGM CILQDFEALT PNLLARTIET VEGGGIVVIL LKSMSSLKQL  60
   61 YTMTMDVHAR YRTEAHGDVV ARFNERFILS LGSNPNCLVV DDELNVLPLS GAKNVKPLPP 120
  121 KEDDELPPKQ LELQELKESL EDVQPAGSLV SLSKTVNQAH AILSFIDAIS EKTLNFTVAL 180
  181 TAGRGRGKSA ALGISIAAAV SHGYSNIFVT SPSPENLKTL FEFIFKGFDA LGYQEHIDYD 240
  241 IIQSTNPDFN KAIVRVDIKR DHRQTIQYIV PQDHQVLGQA ELVVIDEAAA IPLPIVKNLL 300
  301 GPYLVFMAST INGYEGTGRS LSLKLIQQLR NQNNTSGRES TQTAVVSRDN KEKDSHLHSQ 360
  361 SRQLREISLD EPIRYAPGDP IEKWLNKLLC LDVTLIKNPR FATRGTPHPS QCNLFVVNRD 420
  421 TLFSYHPVSE NFLEKMMALY VSSHYKNSPN DLQLMSDAPA HKLFVLLPPI DPKDGGRIPD 480
  481 PLCVIQIALE GEISKESVRN SLSRGQRAGG DLIPWLISQQ FQDEEFASLS GARIVRIATN 540
  541 PEYASMGYGS RAIELLRDYF EGKFTDMSED VRPKDYSIKR VSDKELAKTN LLKDDVKLRD 600
  601 AKTLPPLLLK LSEQPPHYL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [721-814]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYLGVSYGLT QSLHKFWKNN SFVPVYLRQT ANDLTGEHTC VMLNVLEGRE SNWLVEFAKD  60
   61 FRKRFLSLLS YDFHKFTAVQ ALSVIESSKK AQDL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	2.58352785213483	bayes_pls_golite062009
binding	2.3830857772509	bayes_pls_golite062009
structural molecule activity	1.70306030734033	bayes_pls_golite062009
RNA helicase activity	1.40594009629203	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.38650114394757	bayes_pls_golite062009
RNA-dependent ATPase activity	1.372924601535	bayes_pls_golite062009
helicase activity	1.17712281740941	bayes_pls_golite062009
ATP-dependent helicase activity	1.12969667337016	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.12969667337016	bayes_pls_golite062009
RNA binding	0.90930722867621	bayes_pls_golite062009
nucleic acid binding	0.61841039337932	bayes_pls_golite062009
	0.506052368661833	bayes_pls_golite062009
DNA binding	0.327221599656875	bayes_pls_golite062009
transcription regulator activity	0.179080000736404	bayes_pls_golite062009
protein binding	0.102043618157662	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0283323446458181	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [815-1056]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDDEKHDNKE LTRTHLDDIF SPFDLKRLDS YSNNLLDYHV IGDMIPMLAL LYFGDKMGDS  60
   61 VKLSSVQSAI LLAIGLQRKN IDTIAKELNL PSNQTIAMFA KIMRKMSQYF RQLLSQSIEE 120
  121 TLPNIKDDAI AEMDGEEIKN YNAAEALDQM EEDLEEAGSE AVQAMREKQK ELINSLNLDK 180
  181 YAINDNSEEW AESQKSLEIA AKAKGVVSLK TGKKRTTEKA EDIYRQEMKA MKKPRKSKKA 240
  241 AN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: