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View Structure Prediction Details

Protein: SPC98
Organism: Saccharomyces cerevisiae
Length: 846 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC98.

Description E-value Query
Range
Subject
Range
Spc98, YNL126W_W303 - SPC98 ORF Verified Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts ...
SPC98 - Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the...
SPC98_YEAST - Spindle pole body component SPC98 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPC98 ...
0.0 [1..846] [1..846]
ALP6_SCHPO - Spindle pole body component alp6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=alp6 PE=1...
alp6 - gamma tubulin complex Spc98 /GCP3 subunit Alp6
0.0 [24..845] [30..812]
GCP3_XENLA - Gamma-tubulin complex component 3 homolog OS=Xenopus laevis GN=tubgcp3 PE=1 SV=1
0.0 [88..799] [131..869]
TUBGCP2 - tubulin, gamma complex associated protein 2
0.0 [42..719] [55..772]
GCP2_MOUSE - Gamma-tubulin complex component 2 OS=Mus musculus GN=Tubgcp2 PE=2 SV=1
0.0 [42..720] [55..773]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELEPTLFGI IEALAPQLLS QSHLQTFVSD VVNLLRSSTK SATQLGPLID FYKLQSLDSP  60
   61 ETTIMWHKIE KFLDALFGIQ NTDDMVKYLS VFQSLLPSNY RAKIVQKSSG LNMENLANHE 120
  121 HLLSPVRAPS IYTEASFENM DRFSERRSMV SSPNRYVP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-707]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSTYSSVTLR QLSNPYYVNT IPEEDILKYV SYTLLATTSA LFPFDHEQIQ IPSKIPNFES  60
   61 GLLHLIFEAG LLYQSLGYKV EKFRMLNISP MKKALIIEIS EELQNYTAFV NNLVSSGTVV 120
  121 SLKSLYREIY ENIIRLRIYC RFTEHLEELS GDTFLIELNI FKSHGDLTIR KIATNLFNSM 180
  181 ISLYYEYLMN WLTKGLLRAT YGEFFIAENT DTNGTDDDFI YHIPIEFNQE RVPAFIPKEL 240
  241 AYKIFMIGKS YIFLEKYCKE VQWTNEFSKK YHVLYQSNSY RGISTNFFEI INDQYSEIVN 300
  301 HTNQILNQKF HYRDVVFALK NILLMGKSDF MDALIEKAND ILATPSDSLP NYKLTRVLQE 360
  361 AVQLSSLRHL MNSPRNSSVI NGLDARVLDL GHGSVGWDVF TLDYILYPPL SLVLNVNRPF 420
  421 GRKEYLRIFN FLWRFKKNNY FYQKEMLKSN DIIRSFKKIR GYNPLIRDII NKLSRISILR 480
  481 TQFQQFNSKM ESYYLNCIIE ENFKEMTRKL QRTENKSQNQ FDLIRLNNGT IELNGILTPK 540
  541 AEVLTKSSS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.19
Match: 1b89A
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.57708254106901 bayes_pls_golite062009
binding 2.38363524631144 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
actin binding 1.74253257307802 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [708-846]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPQKHAIEK TLNIDELESV HNTFLTNILS HKLFATNTSE ISVGDYSGQP YPTSLVLLLN  60
   61 SVYEFVKVYC NLNDIGYEIF IKMNLNDHEA SNGLLGKFNT NLKEIVSQYK NFKDRLYIFR 120
  121 ADLKNDGDEE LFLLSKSLR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.31927971777231 bayes_pls_golite062009
protein binding 0.614639185145051 bayes_pls_golite062009
catalytic activity 0.370165934559297 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle