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View Structure Prediction Details

Protein: SPC98
Organism: Saccharomyces cerevisiae
Length: 846 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC98.

Description E-value Query
Range
Subject
Range
Spc98, YNL126W_W303 - SPC98 ORF Verified Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts ...
SPC98 - Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the...
SPC98_YEAST - Spindle pole body component SPC98 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPC98 ...
0.0 [1..846] [1..846]
ALP6_SCHPO - Spindle pole body component alp6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=alp6 PE=1...
alp6 - gamma tubulin complex Spc98 /GCP3 subunit Alp6
0.0 [24..845] [30..812]
GCP3_XENLA - Gamma-tubulin complex component 3 homolog OS=Xenopus laevis GN=tubgcp3 PE=1 SV=1
0.0 [88..799] [131..869]
TUBGCP2 - tubulin, gamma complex associated protein 2
0.0 [42..719] [55..772]
GCP2_MOUSE - Gamma-tubulin complex component 2 OS=Mus musculus GN=Tubgcp2 PE=2 SV=1
0.0 [42..720] [55..773]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELEPTLFGI IEALAPQLLS QSHLQTFVSD VVNLLRSSTK SATQLGPLID FYKLQSLDSP  60
   61 ETTIMWHKIE KFLDALFGIQ NTDDMVKYLS VFQSLLPSNY RAKIVQKSSG LNMENLANHE 120
  121 HLLSPVRAPS IYTEASFENM DRFSERRSMV SSPNRYVP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-707]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSTYSSVTLR QLSNPYYVNT IPEEDILKYV SYTLLATTSA LFPFDHEQIQ IPSKIPNFES  60
   61 GLLHLIFEAG LLYQSLGYKV EKFRMLNISP MKKALIIEIS EELQNYTAFV NNLVSSGTVV 120
  121 SLKSLYREIY ENIIRLRIYC RFTEHLEELS GDTFLIELNI FKSHGDLTIR KIATNLFNSM 180
  181 ISLYYEYLMN WLTKGLLRAT YGEFFIAENT DTNGTDDDFI YHIPIEFNQE RVPAFIPKEL 240
  241 AYKIFMIGKS YIFLEKYCKE VQWTNEFSKK YHVLYQSNSY RGISTNFFEI INDQYSEIVN 300
  301 HTNQILNQKF HYRDVVFALK NILLMGKSDF MDALIEKAND ILATPSDSLP NYKLTRVLQE 360
  361 AVQLSSLRHL MNSPRNSSVI NGLDARVLDL GHGSVGWDVF TLDYILYPPL SLVLNVNRPF 420
  421 GRKEYLRIFN FLWRFKKNNY FYQKEMLKSN DIIRSFKKIR GYNPLIRDII NKLSRISILR 480
  481 TQFQQFNSKM ESYYLNCIIE ENFKEMTRKL QRTENKSQNQ FDLIRLNNGT IELNGILTPK 540
  541 AEVLTKSSS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.19
Match: 1b89A
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.57708254106901 bayes_pls_golite062009
binding 2.38363524631144 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
actin binding 1.74253257307802 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [708-846]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPQKHAIEK TLNIDELESV HNTFLTNILS HKLFATNTSE ISVGDYSGQP YPTSLVLLLN  60
   61 SVYEFVKVYC NLNDIGYEIF IKMNLNDHEA SNGLLGKFNT NLKEIVSQYK NFKDRLYIFR 120
  121 ADLKNDGDEE LFLLSKSLR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.710 c.1.15 Xylose isomerase-like
View Download 0.614 d.79.1 YjgF-like
View Download 0.610 c.16.1 Lumazine synthase
View Download 0.652 c.49.2 ATP synthase (F1-ATPase), gamma subunit
View Download 0.685 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.710 c.1.15 Xylose isomerase-like
View Download 0.685 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.652 c.49.2 ATP synthase (F1-ATPase), gamma subunit
View Download 0.614 d.79.1 YjgF-like
View Download 0.610 c.16.1 Lumazine synthase
View Download 0.557 d.58.8 Viral DNA-binding domain
View Download 0.528 d.58.29 Adenylyl and guanylyl cyclase catalytic domain
View Download 0.520 c.16.1 Lumazine synthase
View Download 0.501 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.496 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.492 a.24.3 Cytochromes
View Download 0.490 d.109.1 Actin depolymerizing proteins
View Download 0.473 a.25.1 Ferritin-like
View Download 0.467 a.25.1 Ferritin-like
View Download 0.462 c.52.1 Restriction endonuclease-like
View Download 0.460 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.430 c.3.1 FAD/NAD(P)-binding domain
View Download 0.427 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.424 d.80.1 Tautomerase/MIF
View Download 0.418 c.66.1 S-adenosyl-L-methionine-dependent methyltransferases
View Download 0.414 a.118.9 ENTH/VHS domain
View Download 0.410 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.409 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.404 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.404 a.1.1 Globin-like
View Download 0.403 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.403 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.401 a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.398 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.396 d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.384 a.24.12 Outer surface protein C (OspC)
View Download 0.360 c.48.1 TK C-terminal domain-like
View Download 0.358 i.11.1 Computational models partly based on NMR data
View Download 0.356 c.61.1 PRTase-like
View Download 0.355 d.13.1 HIT-like
View Download 0.354 d.58.29 Adenylyl and guanylyl cyclase catalytic domain
View Download 0.353 d.79.5 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF
View Download 0.333 c.1.8 (Trans)glycosidases
View Download 0.332 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.332 a.26.1 4-helical cytokines
View Download 0.329 a.3.1 Cytochrome c
View Download 0.325 c.23.5 Flavoproteins
View Download 0.312 d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.304 a.118.9 ENTH/VHS domain
View Download 0.299 c.50.1 Macro domain-like
View Download 0.298 a.182.1 GatB/YqeY domain
View Download 0.296 f.14.1 Voltage-gated potassium channels
View Download 0.295 c.17.1 Caspase-like
View Download 0.285 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.282 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.282 c.23.5 Flavoproteins
View Download 0.278 d.79.4 Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain
View Download 0.277 a.39.1 EF-hand
View Download 0.273 d.80.1 Tautomerase/MIF
View Download 0.271 a.1.1 Globin-like
View Download 0.264 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.264 a.4.5 "Winged helix" DNA-binding domain
View Download 0.263 d.79.1 YjgF-like
View Download 0.261 d.56.1 GroEL-intermediate domain like
View Download 0.253 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.252 c.23.10 SGHN hydrolase
View Download 0.247 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.241 a.7.7 BAG domain
View Download 0.238 f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.231 d.75.2 DNA repair protein MutS, domain I
View Download 0.230 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.227 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.226 a.47.2 t-snare proteins
View Download 0.225 a.142.1 PTS-regulatory domain, PRD
View Download 0.225 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.225 a.25.1 Ferritin-like
View Download 0.215 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.213 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.208 a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.202 a.28.1 ACP-like
View Download 0.201 f.1.4 Bcl-2 inhibitors of programmed cell death

Predicted functions:

Term Confidence Notes
binding 1.31927971777231 bayes_pls_golite062009
protein binding 0.614639185145051 bayes_pls_golite062009
catalytic activity 0.370165934559297 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle