YRC Public Data Repository - Protein Structure Prediction

Protein:	LAT1
Organism:	Saccharomyces cerevisiae
Length:	482 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAT1.

Description	E-value	Query Range	Subject Range
gi\|162458262, gi... - gi\|5669871\|gb\|AAD46491.1\|AF135014_1 dihydrolipoamide S-acetyltransferase [Zea mays], gi\|162458262\|re...	0.0	[18..482]	[100..542]
gi\|4585966, gi\|2... - gi\|4585966\|gb\|AAD25602.1\|AC005287_4 Putative dihyrdolipoamide acetyltransferase [Arabidopsis thalian...	0.0	[32..482]	[86..516]
DLAT - dihydrolipoamide S-acetyltransferase	0.0	[3..482]	[154..614]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[3..482]	[155..615]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[3..482]	[155..615]
LAT1 - Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes... ODP2_YEAST - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochond... gi\|207341691 - gi\|207341691\|gb\|EDZ69677.1\| YNL071Wp-like protein [Saccharomyces cerevisiae AWRI1631]	0.0	[1..482]	[1..482]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAFVRVVPR ISRSSVLTRS LRLQLRCYAS YPEHTIIGMP ALSPTMTQGN LAAWTKKEGD  60
   61 QLSPGEVIAE IETDKAQMDF EFQEDGYLAK ILVPEGTKDI PVNKPIAVYV EDKADVPAFK 120
  121 DFKLEDSGSD SKTSTKAQPA EPQAEKKQEA PAEETKTSAP E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	287.025158
Match:	1fyc__
Description:	Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [162-233]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKKSDVAAPQ GRIFASPLAK TIALEKGISL KDVHGTGPRG RITKADIESY LEKSSKQSSQ  60
   61 TSGAAAATPA AA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.85005
Match:	1ebdC_
Description:	E3-binding domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	0.79135670574828	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [234-482]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSSTTAGSAP SPSSTASYED VPISTMRSII GERLLQSTQG IPSYIVSSKI SISKLLKLRQ  60
   61 SLNATANDKY KLSINDLLVK AITVAAKRVP DANAYWLPNE NVIRKFKNVD VSVAVATPTG 120
  121 LLTPIVKNCE AKGLSQISNE IKELVKRARI NKLAPEEFQG GTICISNMGM NNAVNMFTSI 180
  181 INPPQSTILA IATVERVAVE DAAAENGFSF DNQVTITGTF DHRTIDGAKG AEFMKELKTV 240
  241 IENPLEMLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	357.08661
Match:	1c4tA_
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: