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View Structure Prediction Details

Protein: PSE1
Organism: Saccharomyces cerevisiae
Length: 1089 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSE1.

Description E-value Query
Range		 Subject
Range
gi|4246, gi|255385 - gi|4246|emb|CAA77639.1| PSE-1 [Saccharomyces cerevisiae], gi|255385|gb|AAA10665.1| protein secretion...
 0.0 [1..1089] [1..1089]
gi|12057236 - gi|12057236|gb|AAG45965.2| Ran binding protein 5 [Mus musculus]
 0.0 [10..1079] [12..1088]
Karybeta3-PA, FB... - The gene Karyopherin Ã?ŽÃ?² 3 is referred to in FlyBase by the symbol Dmel\KaryÃ?ŽÃ?²3 (...
 0.0 [14..1079] [10..1087]
IMB3_SCHPO - Importin subunit beta-3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sal3 PE=3 SV=1
sal3 - karyopherin Sal3
 0.0 [2..1079] [3..1086]
RANBP6 - RAN binding protein 6
 0.0 [9..1076] [16..1090]
gi|15241189, gi|... - gi|15293299|gb|AAK93760.1| unknown protein [Arabidopsis thaliana], gi|15241189|ref|NP_197483.1| emb2...
 0.0 [12..1079] [24..1105]
imb-3 - importin beta, nuclear transport factor status:Confirmed UniProt:Q9N5V3 protein_id:AAF39782.2
 0.0 [9..1065] [3..1069]

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Predicted Domain #1
Region A:
Residues: [1-246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALPEEVNR TLLQIVQAFA SPDNQIRSVA EKALSEEWIT ENNIEYLLTF LAEQAAFSQD  60
   61 TTVAALSAVL FRKLALKAPP SSKLMIMSKN ITHIRKEVLA QIRSSLLKGF LSERADSIRH 120
  121 KLSDAIAECV QDDLPAWPEL LQALIESLKS GNPNFRESSF RILTTVPYLI TAVDINSILP 180
  181 IFQSGFTDAS DNVKIAAVTA FVGYFKQLPK SEWSKLGILL PSLLNSLPRF LDDGKDDALA 240
  241 SVFESL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [247-439] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IELVELAPKL FKDMFDQIIQ FTDMVIKNKD LEPPARTTAL ELLTVFSENA PQMCKSNQNY  60
   61 GQTLVMVTLI MMTEVSIDDD DAAEWIESDD TDDEEEVTYD HARQALDRVA LKLGGEYLAA 120
  121 PLFQYLQQMI TSTEWRERFA AMMALSSAAE GCADVLIGEI PKILDMVIPL INDPHPRVQY 180
  181 GCCNVLGQIS TDF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear export signal receptor activity 2.13470398426489 bayes_pls_golite062009
RNA binding 1.91507786651888 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
nucleic acid binding 1.00841167631924 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
transcription regulator activity 0.385452858197632 bayes_pls_golite062009
mRNA binding 0.37278269424461 bayes_pls_golite062009
DNA binding 0.309260217284589 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [440-534] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPFIQRTAHD RILPALISKL TSECTSRVQT HAAAALVNFS EFASKDILEP YLDSLLTNLL  60
   61 VLLQSNKLYV QEQALTTIAF IAEAAKNKFI KYYDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [535-632] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMPLLLNVLK VNNKDNSVLK GKCMECATLI GFAVGKEKFH EHSQELISIL VALQNSDIDE  60
   61 DDALRSYLEQ SWSRICRILG DDFVPLLPIV IPPLLITA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [633-910] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KATQDVGLIE EEEAANFQQY PDWDVVQVQG KHIAIHTSVL DDKVSAMELL QSYATLLRGQ  60
   61 FAVYVKEVME EIALPSLDFY LHDGVRAAGA TLIPILLSCL LAATGTQNEE LVLLWHKASS 120
  121 KLIGGLMSEP MPEITQVYHN SLVNGIKVMG DNCLSEDQLA AFTKGVSANL TDTYERMQDR 180
  181 HGDGDEYNEN IDEEEDFTDE DLLDEINKSI AAVLKTTNGH YLKNLENIWP MINTFLLDNE 240
  241 PILVIFALVV IGDLIQYGGE QTASMKNAFI PKVTECLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [911-1089] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPDARIRQAA SYIIGVCAQY APSTYADVCI PTLDTLVQIV DFPGSKLEEN RSSTENASAA  60
   61 IAKILYAYNS NIPNVDTYTA NWFKTLPTIT DKEAASFNYQ FLSQLIENNS PIVCAQSNIS 120
  121 AVVDSVIQAL NERSLTEREG QTVISSVKKL LGFLPSSDAM AIFNRYPADI MEKVHKWFA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle