YRC Public Data Repository - Protein Structure Prediction

Protein:	ADE4
Organism:	Saccharomyces cerevisiae
Length:	510 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE4.

Description	E-value	Query Range	Subject Range
PUR1_YEAST - Amidophosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE4 PE=1... gi\|190408526 - gi\|190408526\|gb\|EDV11791.1\| phosphoribosylpyrophosphate amidotransferase [Saccharomyces cerevisiae R... gi\|151946008 - gi\|151946008\|gb\|EDN64240.1\| phosphoribosylpyrophosphate amidotransferase [Saccharomyces cerevisiae Y... gi\|207342051 - gi\|207342051\|gb\|EDZ69932.1\| YMR300Cp-like protein [Saccharomyces cerevisiae AWRI1631] ADE4 - Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes fir...	0.0	[1..510]	[1..510]
gi\|186896012, gi... - gi\|186896012\|ref\|YP_001873124.1\| amidophosphoribosyltransferase [Yersinia pseudotuberculosis PB1/+],... gi\|170023776, gi... - gi\|170023776\|ref\|YP_001720281.1\| amidophosphoribosyltransferase [Yersinia pseudotuberculosis YPIII],... gi\|165992676, gi... - gi\|166008294\|ref\|ZP_02229192.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Antiqua str. ... gi\|165925204, gi... - gi\|165925204\|ref\|ZP_02221036.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Orientalis st... gi\|167399405, gi... - gi\|167399405\|ref\|ZP_02304929.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Antiqua str. ... gi\|166214252, gi... - gi\|166214252\|ref\|ZP_02240287.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Antiqua str. ... gi\|21958396, gi\|... - gi\|22125500\|ref\|NP_668923.1\| amidophosphoribosyltransferase [Yersinia pestis KIM], gi\|21958396\|gb\|AA... gi\|167056353, gi... - gi\|167424471\|ref\|ZP_02316224.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Mediaevalis s... gi\|25286954 - pir\|\|AD0338 amidophosphoribosyltransferase (EC 2.4.2.14) [imported] - Yersinia pestis (strain CO92) gi\|167421176, gi... - gi\|167421176\|ref\|ZP_02312929.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Orientalis st... gi\|51596931, gi\|... - gi\|51596931\|ref\|YP_071122.1\| amidophosphoribosyltransferase [Yersinia pseudotuberculosis IP 32953], ... gi\|153947612, gi... - gi\|77629660\|ref\|ZP_00792246.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Yers... gi\|45437045, gi\|... - gi\|45442181\|ref\|NP_993720.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Microtus str. 91... gi\|15980750, gi\|... - gi\|218929844\|ref\|YP_002347719.1\| amidophosphoribosyltransferase [Yersinia pestis CO92], gi\|16122976\|... gi\|165937197, gi... - gi\|89103390\|ref\|ZP_01175970.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Yers... gi\|149365246, gi... - gi\|149365246\|ref\|ZP_01887281.1\| amidophosphoribosyltransferase [Yersinia pestis CA88-4125], gi\|14929... Q668X5\|Q668X5_YERPS - Amidophosphoribosyltransferase - Yersinia pseudotuberculosis gi\|229694708, gi... - gi\|229838342\|ref\|ZP_04458501.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Orientalis st... gi\|229895372, gi... - gi\|229895372\|ref\|ZP_04510545.1\| amidophosphoribosyltransferase [Yersinia pestis Pestoides A], gi\|229... gi\|229688456, gi... - gi\|229898908\|ref\|ZP_04514053.1\| amidophosphoribosyltransferase [Yersinia pestis biovar Orientalis st... gi\|108779980, gi... - gi\|108808067\|ref\|YP_651983.1\| amidophosphoribosyltransferase [Yersinia pestis Antiqua], gi\|108779980... gi\|108775985, gi... - gi\|229902692\|ref\|ZP_04517809.1\| amidophosphoribosyltransferase [Yersinia pestis Nepal516], gi\|229680... gi\|77635318, gi\|... - gi\|77635318\|ref\|ZP_00797404.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Yers...	0.0	[1..506]	[1..503]
gi\|213852683 - gi\|213852683\|ref\|ZP_03382215.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ... gi\|16761287 - gi\|16761287\|ref\|NP_456904.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ser... gi\|213426983 - gi\|213426983\|ref\|ZP_03359733.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ... gi\|213161329 - gi\|213161329\|ref\|ZP_03347039.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ... gi\|213646795 - gi\|213646795\|ref\|ZP_03376848.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ... gi\|213582920 - gi\|213582920\|ref\|ZP_03364746.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ... gi\|25286956, gi\|... - gi\|25286956\|pir\|\|AH0801 amidophosphoribosyltransferase (EC 2.4.2.14) [imported] - Salmonella enteric... gi\|29141017, gi\|... - gi\|29141017\|ref\|NP_804359.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica ser...	0.0	[1..506]	[1..503]
PUR1_LACKL - Amidophosphoribosyltransferase OS=Lachancea kluyveri GN=ADE4 PE=3 SV=1	0.0	[1..510]	[1..510]
lcl\|NC_016856.1_... - [gene=purF] [protein=amidophosphoribosyltransferase] [protein_id=YP_005238444.1] [location=complemen... gi\|16420905, gi\|... - gi\|16765689\|ref\|NP_461304.1\| amidophosphoribosyltransferase [Salmonella typhimurium LT2], gi\|1642090... gi\|167993050, gi... - gi\|205328827\|gb\|EDZ15591.1\| amidophosphoribosyltransferase [Salmonella enterica subsp. enterica sero...	0.0	[1..506]	[1..503]
gi\|115513626, gi... - gi\|117624502\|ref\|YP_853415.1\| amidophosphoribosyltransferase [Escherichia coli APEC O1], gi\|11551362... gi\|187771012, gi... - gi\|187771012\|gb\|EDU34856.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4196], g... gi\|91073182, gi\|... - gi\|91211608\|ref\|YP_541594.1\| amidophosphoribosyltransferase [Escherichia coli UTI89], gi\|91073182\|gb... gi\|168767942, gi... - gi\|189362890\|gb\|EDU81309.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4486], g... gi\|15832450, gi\|... - gi\|15832450\|ref\|NP_311223.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. Sakai], g... gi\|189372889, gi... - gi\|189372889\|gb\|EDU91305.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC869], gi... gi\|110642516, gi... - gi\|110642516\|ref\|YP_670246.1\| amidophosphoribosyltransferase [Escherichia coli 536], gi\|110344108\|gb... gi\|168780171, gi... - gi\|189001887\|gb\|EDU70873.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4076], g... gi\|195935691 - gi\|195935691\|ref\|ZP_03081073.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4024... gi\|189378916, gi... - gi\|189378916\|gb\|EDU97332.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC508], gi... gi\|208813534, gi... - gi\|208813534\|ref\|ZP_03254863.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4045... gi\|208809191, gi... - gi\|208809191\|ref\|ZP_03251528.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4206... gi\|188017294, gi... - gi\|188017294\|gb\|EDU55416.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4113], g... gi\|189368340, gi... - gi\|189368340\|gb\|EDU86756.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4501], g... gi\|168755068, gi... - gi\|189357748\|gb\|EDU76167.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4401], g... gi\|83570132, gi\|... - gi\|83570132\|ref\|ZP_00921579.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Shig... gi\|75243123, gi\|... - gi\|75243123\|ref\|ZP_00726829.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|227887370, gi... - gi\|227887370\|ref\|ZP_04005175.1\| amidophosphoribosyltransferase [Escherichia coli 83972], gi\|22783572... gi\|188495078, gi... - gi\|75515677\|ref\|ZP_00737812.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|254794205, gi... - gi\|254794205\|ref\|YP_003079042.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. TW143... gi\|209158630, gi... - gi\|209397230\|ref\|YP_002271721.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC411... gi\|208821678, gi... - gi\|208821678\|ref\|ZP_03261998.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. EC4042... gi\|217327559, gi... - gi\|217327559\|ref\|ZP_03443642.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 str. TW1458... gi\|215265597, gi... - gi\|215487525\|ref\|YP_002329956.1\| amidophosphoribosyltransferase [Escherichia coli O127:H6 str. E2348... gi\|218690472, gi... - gi\|218690472\|ref\|YP_002398684.1\| amidophosphoribosyltransferase [Escherichia coli ED1a], gi\|21842803... gi\|218365994, gi... - gi\|218559225\|ref\|YP_002392138.1\| amidophosphoribosyltransferase [Escherichia coli S88], gi\|218365994... gi\|218432939, gi... - gi\|218705842\|ref\|YP_002413361.1\| amidophosphoribosyltransferase [Escherichia coli UMN026], gi\|218432... gi\|218370774, gi... - gi\|218700788\|ref\|YP_002408417.1\| amidophosphoribosyltransferase [Escherichia coli IAI39], gi\|2183707... gi\|26248700, gi\|... - gi\|26248700\|ref\|NP_754740.1\| amidophosphoribosyltransferase [Escherichia coli CFT073], gi\|26109105\|g... gi\|209764850, gi... - pir\|\|E85872 amidophosphoribosyltransferase [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|12516671, gi\|... - gi\|15802859\|ref\|NP_288886.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7 EDL933], gi\|12... gi\|15832450, gi\|... - gi\|15832450\|ref\|NP_311223.1\| amidophosphoribosyltransferase [Escherichia coli O157:H7], gi\|13362666\|...	0.0	[1..506]	[1..503]
EG10794 - amidophosphoribosyltransferase / Amidophosphoribosyltransferase, purine synthesis; also known as glu... gi\|124526477, gi... - gi\|124526477\|ref\|ZP_01698430.1\| amidophosphoribosyltransferase [Escherichia coli B], gi\|124501948\|gb... gi\|253974222, gi... - gi\|254162321\|ref\|YP_003045429.1\| amidophosphoribosyltransferase [Escherichia coli B str. REL606], gi... gi\|24052752, gi\|... - gi\|24113684\|ref\|NP_708194.1\| amidophosphoribosyltransferase [Shigella flexneri 2a str. 301], gi\|2405... gi\|253323808, gi... - gi\|254289082\|ref\|YP_003054830.1\| amidophosphoribosyltransferase [Escherichia coli BL21(DE3)], gi\|253... gi\|30041993, gi\|... - gi\|30063738\|ref\|NP_837909.1\| amidophosphoribosyltransferase [Shigella flexneri 2a str. 2457T], gi\|30... gi\|242377945, gi... - gi\|251785672\|ref\|YP_002999976.1\| hypothetical protein B21_02197 [Escherichia coli BL21], gi\|24237794... gi\|238859974, gi... - gi\|238901487\|ref\|YP_002927283.1\| amidophosphoribosyltransferase [Escherichia coli BW2952], gi\|238859... gi\|89109132, gi\|... - gi\|89109132\|ref\|AP_002912.1\| amidophosphoribosyltransferase [Escherichia coli str. K-12 substr. W311... gi\|157156919, gi... - gi\|75187094\|ref\|ZP_00700361.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|195183051 - gi\|195183051\|dbj\|BAG66611.1\| amidophosphoribosyltransferase [Escherichia coli O111:H-] gi\|194429427, gi... - gi\|75209299\|ref\|ZP_00709539.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|83588295, gi\|... - gi\|83588295\|ref\|ZP_00926920.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|187427752, gi... - gi\|75177899\|ref\|ZP_00697961.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Shig... gi\|193062290, gi... - gi\|75259771\|ref\|ZP_00731073.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|74312829, gi\|... - gi\|74312829\|ref\|YP_311248.1\| amidophosphoribosyltransferase [Shigella sonnei Ss046], gi\|73856306\|gb\|... gi\|191169476, gi... - gi\|75227192\|ref\|ZP_00713996.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... gi\|193068153, gi... - gi\|75238095\|ref\|ZP_00722100.1\| COG0034: Glutamine phosphoribosylpyrophosphate amidotransferase [Esch... PUR1_SHIFL - Amidophosphoribosyltransferase OS=Shigella flexneri GN=purF PE=3 SV=2 PUR1_ECOLI - Amidophosphoribosyltransferase (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase... gi\|170019379, gi... - gi\|170019379\|ref\|YP_001724333.1\| amidophosphoribosyltransferase [Escherichia coli ATCC 8739], gi\|169... EG10794 - amidophosphoribosyltransferase / Amidophosphoribosyltransferase, purine synthesis; also known as glu... gi\|169889763, gi... - gi\|170081928\|ref\|YP_001731248.1\| amidophosphoribosyltransferase [Escherichia coli str. K-12 substr. ... gi\|218554867, gi... - gi\|218554867\|ref\|YP_002387780.1\| amidophosphoribosyltransferase [Escherichia coli IAI1], gi\|21836163...	0.0	[1..506]	[1..503]
gi\|42593 - gi\|42593\|emb\|CAA30971.1\| amidophosphoribosyltransferase [Escherichia coli]	0.0	[1..506]	[1..503]

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Predicted Domain #1

Region A:
Residues: [1-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGILGIVLA NQTTPVAPEL CDGCIFLQHR GQDAAGIATC GSRGRIYQCK GNGMARDVFT  60
   61 QQRVSGLAGS MGIAHLRYPT AGSSANSEAQ PFYVNSPYGI NLAHNGNLVN TASLKRYMDE 120
  121 DVHRHINTDS DSELLLNIFA AELEKHNKYR VNNEDVFHAL EGVYRLCRGG YACVGLLAGF 180
  181 ALFGFRDPNG IRPLLFGERE NPDGTKDYML ASESVVFKAH NFTKYRDLKP GEAVIIPKNC 240
  241 SKGEPEFKQV VPINSYRPDL FEYVYFARPD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [458-510]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITKFEDGVFT GNYVTGVEDG YIQELEEKRE SIANNSSDMK AEVDIGLYNC ADY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1526.0
Match:	1ecbA_
Description:	Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uracil phosphoribosyltransferase activity	2.36237864658341	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.51875493459374	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
adenine phosphoribosyltransferase activity	0.985266832225609	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	0.625087274084001	bayes_pls_golite062009
nucleic acid binding	0.283725923623827	bayes_pls_golite062009
ligase activity	0.204093345072151	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009
endopeptidase activity	0.0940838340168359	bayes_pls_golite062009
peptidase activity	0.0898497842822991	bayes_pls_golite062009
transcription regulator activity	0.057753538747651	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.012663147802059	bayes_pls_golite062009
protein binding	0.00621436730716318	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [271-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVLDGISVYH TRLAMGSKLA ENILKQLKPE DIDVVIPVPD TARTCALECA NVLGKPYREG  60
   61 FVKNRYVGRT FIMPNQRERV SSVRRKLNPM ESEFKGKKVL IVDDSIVRGT TSKEIVNMAK 120
  121 ESGATKVYFA SAAPAIRYNH IYGIDLTDTK NLIAYNRTDE EVAEVIGCER VIYQSLEDLI 180
  181 DCCKTDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1526.0
Match:	1ecbA_
Description:	Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: