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View Structure Prediction Details

Protein: YMR185W
Organism: Saccharomyces cerevisiae
Length: 981 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YMR185W.

Description E-value Query
Range
Subject
Range
YMR185W - Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elo...
RTP1_YEAST - RNA polymerase II assembly factor RTP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
0.0 [1..981] [1..981]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [448..936] [318..816]
gi|16416012 - gi|16416012|emb|CAD01123.1| conserved hypothetical protein [Neurospora crassa]
0.0 [448..936] [313..811]
gi|16769274 - gi|16769274|gb|AAL28856.1| LD22423p [Drosophila melanogaster]
0.0 [538..934] [388..744]
SPBC20F10.08c - conserved eukaryotic protein
RTP1_SCHPO - RNA polymerase II assembly factor rtp1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rtp...
2.0E-81 [608..975] [422..735]
gi|12698037 - gi|12698037|dbj|BAB21837.1| KIAA1746 protein [Homo sapiens]
1.0E-60 [730..934] [841..1031]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEDKEQKIN IHDILNTRPK LTKKTALDVF FEDLDDNVIT PINEYVLDSG SSSSSSIYQA  60
   61 LKCSNNNEFV AVLLQKFQNL HIHVLEQQRR LIESKSDLLP ISLHDMKYVD ELINLLIIHG 120
  121 IDANLSPTMK IPFDSKRINT FKKGQKSAEY ET

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [153-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRWHTINNDT LSQVITVFYN VLTSERSSDY LREIISKGSA YANILLGLIV LHLQLPNRYS  60
   61 SQMITNLEDT QETYTLFGVY TLLVETIQDE KVREPILSKL TTLTLRRPEN GLISLIDFVL 120
  121 GVRDAEDIDI EKFNRIYQIL MSKPKTMTNL QYLTELFKQI YDGLTFVNRP ILVTCLNGLI 180
  181 LKFYLRNKRI VNDFLFKKVR SIIFNSPLTD HTAKEL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.4666436207573 bayes_pls_golite062009
protein binding 1.12452075263773 bayes_pls_golite062009
nucleic acid binding 0.410251595672781 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [369-563]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDVINVLISL SKNSSSDLLN DLVTSCPDED GTTPGQFFLY VWIYALFLKK NQKLDPLEIN  60
   61 KLSISDNKST DSIHFPEQSS SKYYEVVLSL LKSLIVITEN FQYLNVLSLN LLNFEHEKWK 120
  121 YLIDLDTQLP YISVKNTDMA ELFFEKGSKN SQISEFLQDM DLSIELFMEF LVLLNDEEQS 180
  181 KTLFLDILKR WVHHT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [564-659]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKSEKRSSDN HSGMPSVTDN ALILMDLKLL ECMNNRFKTK IVNKPKDVLI VIDQLIDVVQ  60
   61 EKDETIQEVE ADSDDEVEEG EETEELDPNE NSSYKI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [660-777]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILQLLSTVLS ESSSSILLQN SYILKSISRK LQSFNTNASE IDALLASIDN ILINGHTTER  60
   61 NDNIEIEMDE ERLDKAITSL HDPLVPIKSY GLTELRHLAE KKSPVISLEK VLQIHLDY

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [778-981]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNMDPFIYL NVIKGLTTLC ELEPETILPL LAEFYANKKK KNRLDDVLKV GEVFINYIQR  60
   61 QNELFQGKLA YLIIDTCLSI VRPNDSKPLD NRWRMSSMSI LGMCLQINAR GVSDRIRDML 120
  121 DCVFGILQLE QPQNHLKDKD DSFLMRRSAV HLIHDLLYST GFDLLPFEYN YDKLKTLLSY 180
  181 VRDQDEDYMV CEQIDKLLTV LDSL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle