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View Structure Prediction Details

Protein: MSN2
Organism: Saccharomyces cerevisiae
Length: 704 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSN2.

Description E-value Query
Range
Subject
Range
gi|4567179 - gi|4567179|gb|AAD23607.1|AC007228_2 BC37295_1 [Homo sapiens]
0.0 [248..703] [19..530]
ZN283_MACFA - Zinc finger protein 283 OS=Macaca fascicularis GN=ZNF283 PE=2 SV=1
0.0 [246..703] [43..546]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVDHDFNSE DILFPIESMS SIQYVENNNP NNINNDVIPY SLDIKNTVLD SADLNDIQNQ  60
   61 ETSLNLGLPP LSFDSPLPVT ETIPSTTDNS LHLKADSNKN RDARTIENDS EIKSTNNASG 120
  121 SGANQYTTLT SPYPMNDILY NMNNPLQSPS PSSVPQNPTI NP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PINTASNETN LSPQTSNGNE TLISPRAQQH TSIKDNRLSL PNGANSNLFI DTNPNNLNEK  60
   61 LRNQLNSDTN SYSNSISNSN SNSTGNLNSS YFNSLNIDSM LDDYVSSDLL LNDDDDDTNL 120
  121 SRRRFSDVIT NQFPSMTNSR NSISHSLDLW NHPKINPSNR NTNLNITTNS TSSSNASPNT 180
  181 TTMNANADS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [352-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIAGNPKNND ATIDNELTQI LNEYNMNFND NLGTSTSGKN KSACPSSFDA NAMTKINPSQ  60
   61 QLQQQLNRVQ HKQLTSSHNN SSTNMKSFNS DLYSRRQRAS LPIIDDSLSY DLVNKQDEDP 120
  121 KNDMLPNSNL SSSQQFIKPS MILSDNASVI AKVATTGLSN DMPFLTEEGE QNANSTPNFD 180
  181 LSITQMNMAP LS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.274545
Match: 1tf6A_
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
structure-specific DNA binding 0.93314267845352 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
double-stranded DNA binding 0.53991278722671 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [544-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASSSSTSLA TNHFYHHFPQ QGHHTMNSKI GSSLRRRKSA VPLMGTVPLT NQQNNISSSS  60
   61 VNSTGNGAGV TKERRPSYRR KSMTPSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 114.06601
Match: 1meyG_
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [631-704]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSSVVIESTK ELEEKPFHCH ICPKSFKRSE HLKRHVRSVH SNERPFACHI CDKKFSRSDN  60
   61 LSQHIKTHKK HGDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.70927
Match: 1jk1A_
Description: ZIF268
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle