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View Structure Prediction Details

Protein: MSN2
Organism: Saccharomyces cerevisiae
Length: 704 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSN2.

Description E-value Query
Range
Subject
Range
gi|4567179 - gi|4567179|gb|AAD23607.1|AC007228_2 BC37295_1 [Homo sapiens]
0.0 [248..703] [19..530]
ZN283_MACFA - Zinc finger protein 283 OS=Macaca fascicularis GN=ZNF283 PE=2 SV=1
0.0 [246..703] [43..546]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVDHDFNSE DILFPIESMS SIQYVENNNP NNINNDVIPY SLDIKNTVLD SADLNDIQNQ  60
   61 ETSLNLGLPP LSFDSPLPVT ETIPSTTDNS LHLKADSNKN RDARTIENDS EIKSTNNASG 120
  121 SGANQYTTLT SPYPMNDILY NMNNPLQSPS PSSVPQNPTI NP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PINTASNETN LSPQTSNGNE TLISPRAQQH TSIKDNRLSL PNGANSNLFI DTNPNNLNEK  60
   61 LRNQLNSDTN SYSNSISNSN SNSTGNLNSS YFNSLNIDSM LDDYVSSDLL LNDDDDDTNL 120
  121 SRRRFSDVIT NQFPSMTNSR NSISHSLDLW NHPKINPSNR NTNLNITTNS TSSSNASPNT 180
  181 TTMNANADS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [352-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIAGNPKNND ATIDNELTQI LNEYNMNFND NLGTSTSGKN KSACPSSFDA NAMTKINPSQ  60
   61 QLQQQLNRVQ HKQLTSSHNN SSTNMKSFNS DLYSRRQRAS LPIIDDSLSY DLVNKQDEDP 120
  121 KNDMLPNSNL SSSQQFIKPS MILSDNASVI AKVATTGLSN DMPFLTEEGE QNANSTPNFD 180
  181 LSITQMNMAP LS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.274545
Match: 1tf6A_
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
structure-specific DNA binding 0.93314267845352 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
double-stranded DNA binding 0.53991278722671 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [544-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASSSSTSLA TNHFYHHFPQ QGHHTMNSKI GSSLRRRKSA VPLMGTVPLT NQQNNISSSS  60
   61 VNSTGNGAGV TKERRPSYRR KSMTPSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 114.06601
Match: 1meyG_
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [631-704]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSSVVIESTK ELEEKPFHCH ICPKSFKRSE HLKRHVRSVH SNERPFACHI CDKKFSRSDN  60
   61 LSQHIKTHKK HGDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.70927
Match: 1jk1A_
Description: ZIF268
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle