YRC Public Data Repository - Protein Structure Prediction

Protein:	ADI1
Organism:	Saccharomyces cerevisiae
Length:	179 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADI1.

Description	E-value	Query Range	Subject Range
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-65	[1..176]	[12..186]
MTND3_ARATH - 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 3 OS=Arabidopsis thaliana GN=ARD3 PE=2 SV=1	6.0E-65	[1..174]	[12..184]
gi\|14522834 - gi\|14522834\|dbj\|BAB61039.1\| iron-deficiency induced gene [Hordeum vulgare]	1.0E-64	[1..176]	[12..186]
MTND_YEAST - 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508... gi\|151946169 - gi\|151946169\|gb\|EDN64400.1\| acireductone dioxygenease [Saccharomyces cerevisiae YJM789] ADI1 - Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; tra... gi\|190408248 - gi\|190408248\|gb\|EDV11513.1\| acireductone Dioxygenease [Saccharomyces cerevisiae RM11-1a]	5.0E-64	[1..179]	[1..179]
gi\|208965780 - gi\|208965780\|dbj\|BAG72904.1\| acireductone dioxygenase 1 [synthetic construct] ADI1 - acireductone dioxygenase 1	9.0E-63	[1..178]	[1..177]

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Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKVYIHDNK VDSDYRAPHN SGTELSLDEL AKLGVIYKYC ANEEEVNEIA RQREYKNRDV  60
   61 VNICEGSFKS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.346	0.918	nucleus	a.4.1	Homeodomain-like

Predicted functions:

Term	Confidence	Notes
binding	1.10919583483877	bayes_pls_golite062009
catalytic activity	0.401988496917198	bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.262317442423345	bayes_pls_golite062009
protein binding	0.133891883527478	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [71-179]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAEFNEKLAT FYQEHLHEDE EIRYCLEGAG YFDVRDASTP ENWIRCLVES GDLLILPPGI  60
   61 YHRFTLTTSN HIKALRLFKD EPKWQAINRS NQADSLPVRK DYIALINQY

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.62
Match:	1l3jA
Description:	Oxalate decarboxylase YvrK
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: