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View Structure Prediction Details

Protein: URA4
Organism: Saccharomyces cerevisiae
Length: 364 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URA4.

Description E-value Query
Range
Subject
Range
gi|168270860 - gi|168270860|dbj|BAG10223.1| dihydropyrimidinase-related protein 3 [synthetic construct]
DPYSL3 - dihydropyrimidinase-like 3
ENSPTRT00000065332 - null
4.0E-99 [4..359] [63..444]
DPYL3_RAT - Dihydropyrimidinase-related protein 3 OS=Rattus norvegicus GN=Dpysl3 PE=1 SV=2
1.0E-98 [4..359] [63..444]
PYRC_BACCL - Dihydroorotase OS=Bacillus caldolyticus GN=pyrC PE=3 SV=1
2.0E-98 [4..359] [50..412]
DPYL3_MOUSE - Dihydropyrimidinase-related protein 3 OS=Mus musculus GN=Dpysl3 PE=1 SV=1
3.0E-98 [4..359] [63..444]
DPYL2_BOVIN - Dihydropyrimidinase-related protein 2 OS=Bos taurus GN=DPYSL2 PE=1 SV=1
5.0E-98 [4..359] [63..444]
DPYL2_CHICK - Dihydropyrimidinase-related protein 2 OS=Gallus gallus GN=DPYSL2 PE=2 SV=1
5.0E-98 [4..359] [63..444]

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Predicted Domain #1
Region A:
Residues: [1-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQEIDLGLT CDMHVHVREG AMCELVTPKI RDGGVSIAYI MPNLQPPITT LDRVIEYKKT  60
   61 LQKLAPKTTF LMSFYLSKDL TPDLIHEAAQ QHAIRGVKCY PAGVTTNSAA GVDPNDFSAF 120
  121 YPIFKAMQEE NLVLNLHGEK PSVHDGDKEP IHVLNAEEAF LPALKKLHND FPNLKIILEH 180
  181 CTSESAIKTI EDINKNVKKA TDVKVAATLT AHHLFLTIDD WAGNPVNFCK PVAKLPNDKK 240
  241 ALVKAAVSGK PYFFFGSDSA PHPVQNKANY EGVCAGVYSQ SFAIPYIAQV FEEQNALENL 300
  301 KGFVSDFGIS FYEVKDSEVA SSDKAILFKK EQVIPQVISD GKDISIIPFK AGDKLSWSVR 360
  361 WEPR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 444.54902
Match: 1j79A_
Description: Dihydroorotase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydroorotase activity 2.32070383330692 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2.20489529944693 bayes_pls_golite062009
deaminase activity 1.79186203771221 bayes_pls_golite062009
catalytic activity 1.70199291046899 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.60895003474033 bayes_pls_golite062009
nucleic acid binding 0.629962267754185 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.573107361273483 bayes_pls_golite062009
transcription regulator activity 0.506159010274668 bayes_pls_golite062009
DNA binding 0.462348875991261 bayes_pls_golite062009
binding 0.459041534336076 bayes_pls_golite062009
hydrolase activity 0.24275130580417 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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