YRC Public Data Repository - Protein Structure Prediction

Protein:	MET17
Organism:	Saccharomyces cerevisiae
Length:	444 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET17.

Description	E-value	Query Range	Subject Range
gi\|7437093 - pir\|\|D72324 O-acetylhomoserine sulfhydrylase - Thermotoga maritima (strain MSB8) gi\|4981416, gi\|1... - gi\|4981416\|gb\|AAD35963.1\|AE001753_19 O-acetylhomoserine sulfhydrylase [Thermotoga maritima MSB8], gi...	0.0	[3..441]	[6..430]
MET17_YEAST - Protein MET17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET17 PE=1 SV=3 gi\|207342855 - gi\|207342855\|gb\|EDZ70489.1\| YLR303Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151940833 - gi\|151940833\|gb\|EDN59215.1\| O-acetylhomoserine (thiol)-lyase [Saccharomyces cerevisiae YJM789] MET17 - Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for s...	0.0	[1..444]	[1..444]
gi\|6014671, gi\|6... - gi\|6014675\|gb\|AAF01454.1\|AF188275_1 O-acetylhomoserine O-acetylserine sulphydrylase [Candida albican...	0.0	[1..441]	[1..440]
MET17_KLULA - Protein MET17 OS=Kluyveromyces lactis GN=MET17 PE=3 SV=3 MET17_KLULA - Protein MET17 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-...	0.0	[1..444]	[1..443]
gi\|14027751, gi\|... - gi\|14027751\|dbj\|BAB54344.1\| O-acetylhomoserine sulfhydrylase [Mesorhizobium loti MAFF303099], gi\|134...	0.0	[2..438]	[4..426]
gi\|254900172, gi... - gi\|254900172\|ref\|ZP_05260096.1\| hypothetical protein LmonJ_10175 [Listeria monocytogenes J0161], gi\|... gi\|153195228, gi... - gi\|254830420\|ref\|ZP_05235075.1\| hypothetical protein Lmon1_03627 [Listeria monocytogenes 10403S], gi... gi\|254935601 - gi\|254935601\|ref\|ZP_05267298.1\| hypothetical protein LmonF6_00660 [Listeria monocytogenes F6900] gi\|153189986, gi... - gi\|254911274\|ref\|ZP_05261286.1\| hypothetical protein LmonJ2_00660 [Listeria monocytogenes J2818], gi... gi\|255025614 - gi\|255025614\|ref\|ZP_05297600.1\| hypothetical protein LmonocytFSL_03410 [Listeria monocytogenes FSL J... gi\|254828338, gi... - gi\|254828338\|ref\|ZP_05233025.1\| hypothetical protein LmonocytogeFSL_07752 [Listeria monocytogenes FS... gi\|47096888, gi\|... - gi\|47096888\|ref\|ZP_00234467.1\| O-acetylhomoserine (thiol)-lyase [Listeria monocytogenes str. 1/2a F6... gi\|224502104 - gi\|224502104\|ref\|ZP_03670411.1\| hypothetical protein LmonFR_06237 [Listeria monocytogenes FSL R2-561... gi\|16802638 - gi\|16802638\|ref\|NP_464123.1\| hypothetical protein lmo0595 [Listeria monocytogenes EGD-e] gi\|224498673 - gi\|224498673\|ref\|ZP_03667022.1\| hypothetical protein LmonF1_02826 [Listeria monocytogenes Finland 19... gi\|25292109, gi\|... - pir\|\|AD1149 O-acetylhomoserine sulfhydrylase homolog lmo0595 [imported] - Listeria monocytogenes (st...	0.0	[3..438]	[5..425]
gi\|28917330, gi\|... - gi\|32415223\|ref\|XP_328091.1\| probable O-acetylhomoserine (thiol)-lyase [MIPS] [Neurospora crassa], g... gi\|85079019 - gi\|85079019\|ref\|XP_956274.1\| probable O-acetylhomoserine (thiol)-lyase [MIPS] [Neurospora crassa OR7...	0.0	[1..440]	[1..428]
gi\|16799679 - gi\|16799679\|ref\|NP_469947.1\| hypothetical protein lin0604 [Listeria innocua Clip11262] gi\|16413044, gi\|... - pir\|\|AD1508 O-acetylhomoserine sulfhydrylase homolog lin0604 [imported] - Listeria innocua (strain C...	0.0	[3..438]	[5..425]
gi\|25292079 - pir\|\|A86634 O-acetylhomoserine sulfhydrylase [imported] - Lactococcus lactis subsp. lactis (strain I... gi\|15672055, gi\|... - gi\|15672055\|ref\|NP_266229.1\| O-acetylhomoserine sulfhydrylase [Lactococcus lactis subsp. lactis Il14...	0.0	[2..438]	[5..426]

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Predicted Domain #1

Region A:
Residues: [1-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSHFDTVQL HAGQENPGDN AHRSRAVPIY ATTSYVFENS KHGSQLFGLE VPGYVYSRFQ  60
   61 NPTSNVLEER IAALEGGAAA LAVSSGQAAQ TLAIQGLAHT GDNIVSTSYL YGGTYNQFKI 120
  121 SFKRFGIEAR FVEGDNPEEF EKVFDERTKA VYLETIGNPK YNVPDFEKIV AIAHKHGIPV 180
  181 VVDNTFGAGG YFCQPIKYGA DIVTHSATKW IGGHGTTIGG IIVDSGKFPW KDYPEKFPQF 240
  241 SQPAEGYHGT IYNEAYGNLA YIVHVRTELL RDLGPLMNPF ASFLLLQGVE TLSLRA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	712.228787
Match:	1gc0A_
Description:	Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	2.82824364293374	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	2.82824364293374	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	1.87460342369605	bayes_pls_golite062009
transcription regulator activity	1.67701710033155	bayes_pls_golite062009
DNA binding	1.4774443071095	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
nucleic acid binding	1.39741122443159	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transcription factor activity	1.15775909410582	bayes_pls_golite062009
binding	1.09053123792737	bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity	0.994935084630764	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
cystathionine beta-lyase activity	0.6849039330512	bayes_pls_golite062009
vitamin binding	0.66463470119531	bayes_pls_golite062009
cystathionine gamma-lyase activity	0.505859361763689	bayes_pls_golite062009
alanine-glyoxylate transaminase activity	0.48682493494502	bayes_pls_golite062009
O-acyltransferase activity	0.452440867878365	bayes_pls_golite062009
cysteine synthase activity	0.417849187928985	bayes_pls_golite062009
structural molecule activity	0.347975812448725	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.271623203801431	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	0.0669652799570574	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [297-444]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERHGENALKL AKWLEQSPYV SWVSYPGLAS HSHHENAKKY LSNGFGGVLS FGVKDLPNAD  60
   61 KETDPFKLSG AQVVDNLKLA SNLANVGDAK TLVIAPYFTT HKQLNDKEKL ASGVTKDLIR 120
  121 VSVGIEFIDD IIADFQQSFE TVFAGQKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	712.228787
Match:	1gc0A_
Description:	Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: