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View Structure Prediction Details

Protein: YLR253W
Organism: Saccharomyces cerevisiae
Length: 569 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR253W.

Description E-value Query
Range
Subject
Range
gi|151941088 - gi|151941088|gb|EDN59468.1| conserved protein [Saccharomyces cerevisiae YJM789]
MCP2_YEAST - ABC1 family protein MCP2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCP2 PE=1 SV=1
YLR253W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purifi...
0.0 [1..569] [1..569]
gi|25534796 - pir||AH2425 hypothetical protein all4960 [imported] - Nostoc sp. (strain PCC 7120)
gi|17134098, gi|... - gi|17232452|ref|NP_489000.1| hypothetical protein all4960 [Nostoc sp. PCC 7120], gi|17134098|dbj|BAB...
0.0 [22..551] [31..526]
YJ19_SYNY3, Y191... - (P73121) Hypothetical protein slr1919, Uncharacterized protein slr1919 OS=Synechocystis sp. (strain ...
gi|7450861 - pir||S75233 ABC transporter slr1919 - Synechocystis sp. (strain PCC 6803)
Y1919_SYNY3 - Uncharacterized protein slr1919 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=slr1919 PE=3 SV=1
4.0E-97 [56..552] [19..490]
YG62_SCHPO - ABC1 family protein C15C4.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC15C4.02 P...
SPBC15C4.02 - ABC1 kinase family protein
5.0E-97 [29..550] [71..588]
UBIB_PASMU - Probable ubiquinone biosynthesis protein ubiB OS=Pasteurella multocida GN=ubiB PE=3 SV=1
UBIB_PASMU - Probable protein kinase UbiB OS=Pasteurella multocida (strain Pm70) GN=ubiB PE=3 SV=1
5.0E-93 [69..563] [9..504]
Y2090_ARATH - Putative ABC1 protein At2g40090 OS=Arabidopsis thaliana GN=At2g40090 PE=2 SV=2
6.0E-92 [31..557] [8..528]
gi|117616972 - gi|117616972|gb|ABK42504.1| ADCK1 [synthetic construct]
ADCK1_MOUSE - Uncharacterized aarF domain-containing protein kinase 1 OS=Mus musculus GN=Adck1 PE=1 SV=1
8.0E-92 [39..531] [14..484]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTKAFFNKL PFEVFRRYVR TGKSIPQRSP RTRKSLLVGG TIASAVVLYN FNDTFHDSVK  60
   61 HTALTTKRIA VVTQATTRCF YHYKRALNKS YENKKEREVA LNKCHKMCAL ITLHALRSNG 120
  121 GIYIKLGQHI GAMTYLLPKE WTDTMIPLQD HCP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.539 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.520 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.547 a.26.1 4-helical cytokines
View Download 0.524 a.63.1 Apolipophorin-III
View Download 0.547 a.26.1 4-helical cytokines
View Download 0.539 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.524 a.63.1 Apolipophorin-III
View Download 0.520 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.492 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.476 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.444 a.63.1 Apolipophorin-III
View Download 0.428 a.24.12 Outer surface protein C (OspC)
View Download 0.425 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.413 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.409 a.168.1 GEF domain of SopE toxin
View Download 0.408 a.85.1 Hemocyanin, N-terminal domain
View Download 0.402 a.74.1 Cyclin-like
View Download 0.397 a.85.1 Hemocyanin, N-terminal domain
View Download 0.396 a.7.4 Smac/diablo
View Download 0.394 a.26.1 4-helical cytokines
View Download 0.393 a.74.1 Cyclin-like
View Download 0.386 a.118.8 TPR-like
View Download 0.385 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.384 a.24.9 alpha-catenin/vinculin
View Download 0.366 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.365 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.361 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.360 a.24.3 Cytochromes
View Download 0.360 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.360 a.118.8 TPR-like
View Download 0.349 d.110.4 SNARE-like
View Download 0.347 b.88.1 Mss4-like
View Download 0.338 a.63.1 Apolipophorin-III
View Download 0.337 a.29.2 Bromodomain
View Download 0.335 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.323 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.320 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.316 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.315 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.314 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.312 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.310 a.24.14 FAT domain of focal adhesion kinase
View Download 0.310 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.308 a.19.1 Fertilization protein
View Download 0.301 a.24.9 alpha-catenin/vinculin
View Download 0.300 a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.298 a.22.1 Histone-fold
View Download 0.297 a.24.4 Hemerythrin
View Download 0.296 a.47.2 t-snare proteins
View Download 0.296 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.294 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.292 a.47.1 STAT
View Download 0.289 a.47.2 t-snare proteins
View Download 0.289 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.286 a.1.2 alpha-helical ferredoxin
View Download 0.282 a.24.9 alpha-catenin/vinculin
View Download 0.282 a.40.1 Calponin-homology domain, CH-domain
View Download 0.281 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.280 a.24.4 Hemerythrin
View Download 0.278 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.272 a.102.4 Terpenoid cylases/Protein prenyltransferases
View Download 0.266 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.265 b.88.1 Mss4-like
View Download 0.261 d.54.1 Enolase N-terminal domain-like
View Download 0.259 f.14.1 Voltage-gated potassium channels
View Download 0.257 a.133.1 Phospholipase A2, PLA2
View Download 0.257 a.24.9 alpha-catenin/vinculin
View Download 0.249 a.26.1 4-helical cytokines
View Download 0.249 a.79.1 Antitermination factor NusB
View Download 0.246 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.245 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.241 a.47.2 t-snare proteins
View Download 0.240 a.24.9 alpha-catenin/vinculin
View Download 0.239 a.133.1 Phospholipase A2, PLA2
View Download 0.237 a.24.9 alpha-catenin/vinculin
View Download 0.236 a.24.9 alpha-catenin/vinculin
View Download 0.236 a.118.1 ARM repeat
View Download 0.236 a.118.1 ARM repeat
View Download 0.235 a.7.8 GAT domain
View Download 0.235 a.26.1 4-helical cytokines
View Download 0.233 a.26.1 4-helical cytokines
View Download 0.232 f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.225 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.223 a.26.1 4-helical cytokines
View Download 0.223 a.47.1 STAT
View Download 0.222 a.7.1 Spectrin repeat
View Download 0.219 d.54.1 Enolase N-terminal domain-like
View Download 0.217 f.13.1 Family A G protein-coupled receptor-like
View Download 0.216 a.74.1 Cyclin-like
View Download 0.216 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.215 f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.214 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.212 a.123.1 Nuclear receptor ligand-binding domain
View Download 0.208 a.133.1 Phospholipase A2, PLA2
View Download 0.205 c.62.1 vWA-like
View Download 0.200 a.24.4 Hemerythrin

Predicted Domain #2
Region A:
Residues: [154-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESTYEEIDEL FKEDLGTSIE DMFLEFNKTP IGVASLAQVH VAKLKNSDGK GSSVAVKCQH  60
   61 PSLKEFIPLD VMLTRTVFEL LDVFFPDYPL TWLGDELQSS IYVELNFTKE AENAEKTRHY 120
  121 FSKFKKQTAL KIPKVIESHK RILIMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.522879
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 2.78878187773119 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.65696220652782 bayes_pls_golite062009
protein serine/threonine kinase activity 2.52043782881479 bayes_pls_golite062009
kinase activity 2.45757516485965 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.08265655536291 bayes_pls_golite062009
binding 1.72646207655432 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transferase activity 1.09650209608069 bayes_pls_golite062009
ATP binding 0.57612786382221 bayes_pls_golite062009
adenyl ribonucleotide binding 0.533622009869642 bayes_pls_golite062009
protein binding 0.529222066176906 bayes_pls_golite062009
adenyl nucleotide binding 0.516315256680509 bayes_pls_golite062009
purine ribonucleotide binding 0.366733507123411 bayes_pls_golite062009
ribonucleotide binding 0.366674148714169 bayes_pls_golite062009
purine nucleotide binding 0.355425813353478 bayes_pls_golite062009
nucleotide binding 0.350202706382045 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [301-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGGKRLDDLE YIDSHGISRS EVSSCLSHIF NNMIFTPNVG IHCDPHGGNL AIRSVKPAKD  60
   61 NGYHNFEIVL FDHGLYRYPS TRTRRLYAKF WLSLLFDKDQ TKMKKYAKGF ANITDEQFPL 120
  121 LAAAITGRSI DAALNYDIST SRTQEEMDVM ANGILEGTLL SDLMSILSRI PRVVLLILKT 180
  181 NDLTRHLDEC LQNP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.522879
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [495-569]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGPERTFLIM TQYCAKTVYD EKVERINSEY ARWSIKWMWE NLTNWIVYER RINQLYFYDF  60
   61 VLWWKKFIPK TWLSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle