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View Structure Prediction Details

Protein: PEX13
Organism: Saccharomyces cerevisiae
Length: 386 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX13.

Description E-value Query
Range
Subject
Range
gi|207342984 - gi|207342984|gb|EDZ70588.1| YLR191Wp-like protein [Saccharomyces cerevisiae AWRI1631]
PEX13_YEAST - Peroxisomal membrane protein PAS20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEX13...
PEX13 - Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interac...
2.0E-96 [1..386] [1..386]
gi|114577535 - gi|114577535|ref|XP_525763.2| PREDICTED: peroxisome biogenesis factor 13 [Pan troglodytes]
PEX13 - peroxisomal biogenesis factor 13
5.0E-75 [1..385] [1..349]
gi|6682845 - gi|6682845|dbj|BAA88906.1| PEX13 [Cricetulus griseus]
3.0E-74 [1..383] [1..349]
PEX13_MOUSE - Peroxisomal membrane protein PEX13 OS=Mus musculus GN=Pex13 PE=1 SV=1
4.0E-74 [1..383] [1..349]
prx-13 - status:Confirmed UniProt:Q19951 protein_id:AAC46665.2
2.0E-48 [75..384] [1..292]
PEX13_SCHPO - Peroxisomal membrane protein pex13 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pex13 P...
pex13 - peroxin-13
3.0E-45 [123..372] [49..288]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
7.0E-29 [211..377] [242..393]

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Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTAVPRPK PWETSASLEE PQRNAQSLSA MMTSNQQDSR PTEESNNSNS ASESAPEVLP  60
   61 RPAALNSSGT YGESNTIPGI YGNSNYGIPY DNNPYSMNSI YGNSIGRYG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [110-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGGSYYGNNY GSFYGGGYGA GAGYGMNNGS GLGESTKATF QLIESLIGAV TGFAQMLEST  60
   61 YMATHNSFFT MISVAEQFGN LKEMLGSFF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.910 0.056 peroxisomal membrane a.7.8 GAT domain

Predicted Domain #3
Region A:
Residues: [199-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIFAIMKFLK KILYRATKGR LGIPPKNFAE SEGSKNKLIE DFQKFNDSGT INSNEKATRR  60
   61 KISWKPLLFF LMAVFGFPYL LNKFITKLQT SGTIRASQGN GSEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1bmbA_
Description: Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.55003340159545 bayes_pls_golite062009
protein binding 2.35325421236395 bayes_pls_golite062009
molecular adaptor activity 0.68555837423221 bayes_pls_golite062009
signal transducer activity 0.644330423191792 bayes_pls_golite062009
molecular transducer activity 0.644330423191792 bayes_pls_golite062009
hydrolase activity 0.31081944790532 bayes_pls_golite062009
protein binding, bridging 0.230308623372106 bayes_pls_golite062009
receptor binding 0.00920732436841987 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [303-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDPSKLEFAR ALYDFVPENP EMEVALKKGD LMAILSKKDP LGRDSDWWKV RTKNGNIGYI  60
   61 PYNYIEIIKR RKKIEHVDDE TRTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.39794
Match: 1aww__
Description: Bruton's tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.49184519104882 bayes_pls_golite062009
protein binding 2.29371158534719 bayes_pls_golite062009
cytoskeletal protein binding 1.67112127425228 bayes_pls_golite062009
transporter activity 1.30447542854757 bayes_pls_golite062009
transmembrane transporter activity 1.08558010881058 bayes_pls_golite062009
actin binding 0.75525840382431 bayes_pls_golite062009
substrate-specific transporter activity 0.566172161499832 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.325817349097199 bayes_pls_golite062009
ion transmembrane transporter activity 0.00508584255499911 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle