YRC Public Data Repository - Protein Structure Prediction

Protein:	YPS1
Organism:	Saccharomyces cerevisiae
Length:	569 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPS1.

Description	E-value	Query Range	Subject Range
YPS1 - Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor gi\|151941285 - gi\|151941285\|gb\|EDN59663.1\| aspartic protease [Saccharomyces cerevisiae YJM789] YPS1_YEAST - Aspartic proteinase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPS1 PE=1 SV=2	0.0	[1..569]	[1..569]
gi\|6180007 - gi\|6180007\|gb\|AAF05750.1\|AF191336_1 pregnancy-associated glycoprotein-11 [Capra hircus]	0.0	[98..477]	[22..379]
gi\|157170280 - gi\|157170280\|gb\|AAI52845.1\| Pepsinogen 4, group I (pepsinogen A) [synthetic construct] ,HsxXG003545,F12... - null PGA3, PGA5, PGA4 - pepsinogen 5, group I (pepsinogen A), pepsinogen 4, group I (pepsinogen A), pepsinogen 3, group I (p...	0.0	[92..477]	[21..387]
gi\|2689727, gi\|5... - gi\|57619120\|ref\|NP_001009868.1\| pregnancy-associated glycoprotein [Felis catus], gi\|2689727\|gb\|AAB91...	0.0	[98..477]	[22..387]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[92..477]	[21..387]
PAG1_BOVIN - Pregnancy-associated glycoprotein 1 OS=Bos taurus PE=1 SV=1	0.0	[98..477]	[22..379]
PEPA4_MACFU - Pepsin A-4 OS=Macaca fuscata fuscata GN=PGA PE=1 SV=1 gi\|38071, gi\|105011 - gi\|38071\|emb\|CAA42425.1\| prepropepsin A; prepropepsinogen A-4 [Macaca fuscata], pir\|\|S19682 pepsin A...	0.0	[98..477]	[23..387]

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Predicted Domain #1

Region A:
Residues: [1-139]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLKTVRSAV LSSLFASQVL GKIIPAANKR DDDSNSKFVK LPFHKLYGDS LENVGSDKKP  60
   61 EVRLLKRADG YEEIIITNQQ SFYSVDLEVG TPPQNVTVLV DTGSSDLWIM GSDNPYCSSN 120
  121 SMGSSRRRVI DKRDDSSSG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.75
Match:	1qdmA
Description:	(Pro)phytepsin; Plant acid proteinase, phytepsin
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [140-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSLINDINPF GWL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [290-326]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSNTYSLYLN DSDAMHGTIL FGAVDHSKYT GTLYTIP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [460-492]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAYVVYDLEN LEISMAQARY NTTSENIEII TSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1346.522879
Match:	1ypsA_
Description:	No description for 1ypsA_ was found.

Predicted functions:

Term	Confidence	Notes
aspartic-type endopeptidase activity	7.28637514153772	bayes_pls_golite062009
aspartic-type peptidase activity	7.28637514153772	bayes_pls_golite062009
peptidase activity	5.78181196721293	bayes_pls_golite062009
endopeptidase activity	5.40359198075797	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	5.39972232367526	bayes_pls_golite062009
hydrolase activity	3.97352810629953	bayes_pls_golite062009
catalytic activity	1.54514410489082	bayes_pls_golite062009
binding	0.742107862879277	bayes_pls_golite062009
protein binding	0.401296299316154	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [153-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGTGSAIGPT ATGLGGGSGT ATQSVPASEA TMDCQQYGTF STSGSSTFRS NNTYFSISYG  60
   61 DGTFASGTFG TDVLDLSDLN VTGLSFAVAN ETNSTMGVLG IGLPELEVTY SGSTASHSGK 120
  121 AYKYDNFPIV LKNSGAI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [327-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVNTLSASGF SSPIQFDVTI NGIGISDSGS SNKTLTTTKI PALLDSGTTL TYLPQTVVSM  60
   61 IATELGAQYS SRIGYYVLDC PSDDSMEIVF DFGGFHINAP LSSFILSTGT TCLLGIIPTS 120
  121 DDTGTILGDS FLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1346.522879
Match:	1ypsA_
Description:	No description for 1ypsA_ was found.

Predicted Domain #4

Region A:
Residues: [493-569]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPSAVKAPGY TNTWSTSASI VTGGNIFTVN SSQTASFSGN LTTSTASATS TSSKRNVGDH  60
   61 IVPSLPLTLI SLLFAFI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: