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View Structure Prediction Details

Protein: ALT1
Organism: Saccharomyces cerevisiae
Length: 592 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALT1.

Description E-value Query
Range		 Subject
Range
ALT1 - Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic...
ALAM_YEAST - Probable alanine aminotransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
gi|190406125 - gi|190406125|gb|EDV09392.1| hypothetical protein SCRG_05073 [Saccharomyces cerevisiae RM11-1a]
gi|207343104 - gi|207343104|gb|EDZ70669.1| YLR089Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151941256 - gi|151941256|gb|EDN59634.1| alanine transaminase [Saccharomyces cerevisiae YJM789]
 0.0 [1..592] [1..592]
gi|8570043 - gi|8570043|dbj|BAA96743.1| 1-aminocyclopropane-1-carboxylate synthase [Prunus persica]
 0.0 [164..591] [34..437]
gi|7576444 - gi|7576444|dbj|BAA94600.1| 1-aminocyclopropane-1-carboxylate synthase [Populus euramericana]
gi|7576444 - dbj|BAA94600.1| 1-aminocyclopropane-1-carboxylate synthase [Populus euramericana]
 0.0 [164..592] [29..434]
ALAT2_ARATH - Alanine aminotransferase 2, mitochondrial OS=Arabidopsis thaliana GN=ALAAT2 PE=2 SV=1
 0.0 [69..592] [12..540]
gi|4090535 - gi|4090535|gb|AAC98809.1| ACC synthase [Carica papaya]
 0.0 [164..592] [32..438]
gi|3643540 - gi|3643540|emb|CAA09477.1| ACC synthase [Citrus sinensis]
 0.0 [164..592] [25..429]
1A1C_TOBAC - 1-aminocyclopropane-1-carboxylate synthase OS=Nicotiana tabacum GN=ACS1 PE=2 SV=1
 0.0 [164..587] [33..434]
1A11_PRUMU - 1-aminocyclopropane-1-carboxylate synthase 1 OS=Prunus mume GN=ACS1 PE=2 SV=1
 0.0 [164..591] [34..437]
gi|7209853 - gi|7209853|dbj|BAA92351.1| 1-aminocyclopropane-1-carboxylate synthase [Malus x domestica]
 0.0 [164..592] [33..438]
gi|18252337 - gi|18252337|gb|AAL66200.1|AF386518_1 1-aminocyclopropane 1-carboxylate synthase 4 [Pyrus communis]
 0.0 [164..591] [33..436]

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Predicted Domain #1
Region A:
Residues: [1-162] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLSAKNHF TVSNSITHVI KSYHIRTLTS SAEKMPHITT PFSTSASSTK LKAFRKVRPV  60
   61 LQRHSSSWIV AQNHRRSLSG QSSLNDLRHL NRFPHHTLKT SNNEFYPAEQ LTLEDVNENV 120
  121 LKAKYAVRGA IPMRAEELKA QLEKDPQSLP FDRIINANIG NP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLQQKPLTY YRQVLSLLQY PEL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [487-592] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAMTLYETFN SLEGIECQKP QGAMYLFPKI DLPFKAVQEA RHLELTPDEF YCKKLLESTG  60
   61 ICTVPGSGFG QEPGTYHLRT TFLAPGLEWI KKWESFHKEF FDQYRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 294.0103
Match: 1iaxA_
Description: 1-aminocyclopropane-1-carboxylate synthase (ACC synthase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
L-aspartate:2-oxoglutarate aminotransferase activity 5.51961002550688 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
4-aminobutyrate transaminase activity 1.82501790383768 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.63055151623667 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.63055151623667 bayes_pls_golite062009
transferase activity 1.44093490824786 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
L-alanine:2-oxoglutarate aminotransferase activity 1.06988190956423 bayes_pls_golite062009
alanine-oxo-acid transaminase activity 1.06988190956423 bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances 0.942545094747784 bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds 0.845816961387768 bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity 0.753443687983955 bayes_pls_golite062009
binding 0.536634592992536 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.319452731970428 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
aromatic-amino-acid:2-oxoglutarate aminotransferase activity 0.0916183433120769 bayes_pls_golite062009
kynureninase activity 0.0900983660305177 bayes_pls_golite062009
cystathionine beta-lyase activity 0.0833010353195099 bayes_pls_golite062009
nucleic acid binding 0.013097682076602 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [186-486] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNQNEQQLVD SKLFKLDAIK RAKSLMEDIG GSVGAYSSSQ GVEGIRKSVA EFITKRDEGE  60
   61 ISYPEDIFLT AGASAAVNYL LSIFCRGPET GVLIPIPQYP LYTATLALNN SQALPYYLDE 120
  121 NSGWSTNPEE IETVVKEAIQ NEIKPTVLVV INPGNPTGAV LSPESIAQIF EVAAKYGTVV 180
  181 IADEVYQENI FPGTKFHSMK KILRHLQREH PGKFDNVQLA SLHSTSKGVS GECGQRGGYM 240
  241 ELTGFSHEMR QVILKLASIS LCPVVTGQAL VDLMVRPPVE GEESFESDQA ERNSIHEKLI 300
  301 T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 294.0103
Match: 1iaxA_
Description: 1-aminocyclopropane-1-carboxylate synthase (ACC synthase)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle