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View Structure Prediction Details

Protein: YLR057W
Organism: Saccharomyces cerevisiae
Length: 849 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR057W.

Description E-value Query
Range
Subject
Range
YLR057W - Putative protein of unknown function; YLR050C is not an essential gene
MNL2_YEAST - Putative endoplasmic reticulum mannosidase MNL2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...
0.0 [1..849] [1..849]
gi|12060546 - gi|12060546|gb|AAG48160.1|AF129497_1 class I alpha-mannosidase 1A [Aspergillus nidulans]
0.0 [30..848] [58..812]
gi|2245570 - gi|2245570|gb|AAB62720.1| alpha 1,2-mannosidase [Spodoptera frugiperda]
0.0 [2..428] [19..465]
MAN1B1 - mannosidase, alpha, class 1B, member 1
0.0 [38..421] [135..505]
MA1A1_MOUSE - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Mus musculus GN=Man1a1 PE=1 SV=1
0.0 [66..421] [112..457]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [8..421] [43..461]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIARLVYSL FRRVRSVLLL FITISLLFYY TFQNEIDILN SYALNDSLPS INNYEHNTEG  60
   61 SSKLDPPDLS STGSDRIATD KENGNVAVDL SDPATLREKN KYFPLLLKGS SHQIGSNLPI 120
  121 SSLLTYKEKY PVLFEYSSPS LTSISQNDVH KIQPAMQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [158-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPDVDMIKQ IKDIFMKSWN QEQLLLKSNL RRESTWPIDL IDSLDTLYLC GETKLFQDSV  60
   61 NIIEDFDFRV PPLAMEVIDI PDITTRVLEG LLSAYELSMD KRLLNKAKHV ADFILRSFDT 120
  121 PNRIPILKYF WKSDLRNRFP DRTVPSGQLT TMALAFIRLS QLTRLNKYFD AVERVFTTIR 180
  181 QSYNEFDMEF MLPDVVDASG CQLLTQEEIE NGAHLKGSSI MKSINENFKF VHCQQLGKFL 240
  241 NPPIDDNSLQ EQSQYQAYRI NEKTVPILEN LFKINDLFQS SYDILDGSSK N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 188.30103
Match: 1fmiA_
Description: Class I alpha-1;2-mannosidase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.22856307472716 bayes_pls_golite062009
binding 0.969273998745536 bayes_pls_golite062009
hydrolase activity 0.457526936444083 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 0.155745745344931 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 0.10867596193378 bayes_pls_golite062009
mannosidase activity 0.0334099347892177 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [449-677]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANAATMDPSI GSEVEAVDEI IEKRNFKDGT KKDSTKNTVG DKSLIDSQTF LTNSISNIFK  60
   61 FMTFRPMLPK QTENKKFNFL NSILTKSQFM PTTNELDVTI RKSYDVSLYS CRLGGILGLS 120
  121 SRVPHRGGVN TKYILPSSLL EMSEIITESC FMLMEEFDGL LPQKFELDPC TDETNGNCEF 180
  181 NGETKSRMIA NGEYETFEND LDVGIKVSNY GKGGNDQKAK RNVLSKDGI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [678-849]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TETQNIKGDT VGSSKSIAEI DGDEVTQIRR VFTLGKDIKP HITTDDTMGS QWKNHPDWPF  60
   61 WVNKVESRRL LDSNIIESIF YMYRISGEQK WRSMGKQSFG ILMQELMELN SGAKGLWQIK 120
  121 EFYENGEKVN NDLPSYWFSR TLKYYLLLFS DGDKVSLDKH ILTQGGHIIK KK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle