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View Structure Prediction Details

Protein: STU2
Organism: Saccharomyces cerevisiae
Length: 888 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STU2.

Description E-value Query
Range
Subject
Range
STU2 - Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics duri...
STU2_YEAST - Protein STU2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STU2 PE=1 SV=1
0.0 [1..888] [1..888]
gi|14599402 - gi|14599402|emb|CAC43454.1| probable microtubule associated protein [Pneumocystis carinii]
0.0 [1..883] [1..826]
gi|6633953 - gi|6633953|dbj|BAA07892.2| KIAA0097 protein [Homo sapiens]
0.0 [3..737] [7..676]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..737] [1..670]
gi|12853560 - gi|12853560|dbj|BAB29779.1| unnamed protein product [Mus musculus]
0.0 [3..737] [1..670]
alp14 - Mad2-dependent spindle checkpoint component
ALP14_SCHPO - Spindle pole body component alp14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=alp14 PE...
0.0 [1..882] [1..803]
gi|11385668, gi|... - gi|148227498|ref|NP_001082053.1| cytoskeleton associated protein 5 [Xenopus laevis], gi|11385668|gb|...
0.0 [3..737] [1..667]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGEEEVDYT TLPLEERLTY KLWKARLEAY KELNQLFRNS VGDISRDDNI QIYWRDPTLF  60
   61 AQYITDSNVV AQEQAIVALN SLIDAFASSS LKNAHNITLI STWTPLLVEK GLTSSRATTK 120
  121 TQSMSCILSL CGLDTSITQS VELVIPFFEK KLPKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.05338750264476 bayes_pls_golite062009
binding 2.86831493830281 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
protein binding 1.63705839411934 bayes_pls_golite062009
transporter activity 1.55621630624352 bayes_pls_golite062009
substrate-specific transporter activity 1.33334123659384 bayes_pls_golite062009
protein transmembrane transporter activity 1.15447282085461 bayes_pls_golite062009
nucleic acid binding 0.804909841250605 bayes_pls_golite062009
transmembrane transporter activity 0.350388174853674 bayes_pls_golite062009
signal sequence binding 0.27824906981293 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.141331164449492 bayes_pls_golite062009
transcription regulator activity 0.123389318446902 bayes_pls_golite062009
DNA binding 0.089209424262799 bayes_pls_golite062009
RNA binding 0.0370585094254798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [156-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAAAANCVYE LMAAFGLTNV NVQTFLPELL KHVPQLAGHG DRNVRSQTMN LIVEIYKVTG  60
   61 NNSDLLEEIL FKKLKPIQVK DLHKLFAKVG DEPSSSKMLF EWEKRELEKK RSQEEEARKR 120
  121 KSILSNDEGE YQIDKDGDTL MGMETDMPPS KQQSGVQIDT FSMLPEETIL DKLPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [331-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFQERITSSK WKDRVEALEE FWDSVLSQTK KLKSTSQNYS NLLGIYGHII QKDANIQAVA  60
   61 LAAQSVELIC DKLKTPGFSK DYVSLVFTPL LDRTKEKKPS VIEAIRKALL TICKYYDPLA 120
  121 SSGRNEDMLK DILEHMKHKT PQIRMECTQL FNASMKEEKD GYSTLQRYLK DEVVPIVIQI 180
  181 VNDTQPAIRT IGFESFAILI KIFGMNTFVK TLEHLDNLKR KKIEETVKTL P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [562-755]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFSIASGSTH STIETNKQTG PMENKFLLKK SSVLPSKRVA SSPLRNDNKS KVNPIGSVAS  60
   61 ASKPSMVAAN NKSRVLLTSK SLATPKNVVA NSTDKNEKLI EEYKYRLQKL QNDEMIWTKE 120
  121 RQSLLEKMNN TENYKIEMIK ENEMLREQLK EAQSKLNEKN IQLRSKEIDV NKLSDRVLSL 180
  181 ENELRNMEIE LDRN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [756-888]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRNDTNLQS MGTISSYSIP SSTVSSNYGV KSLSSALPFK EEEDVRRKED VNYERRSSES  60
   61 IGDLPHRVNS LNIRPYRKNG TGVSSVSDDL DIDFNDSFAS EESYKRAAAV TSTLKARIEK 120
  121 MKAKSRREGT TRT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle