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View Structure Prediction Details

Protein: TPO1
Organism: Saccharomyces cerevisiae
Length: 586 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPO1.

Description E-value Query
Range
Subject
Range
TPO1 - Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of poly...
TPO1_YEAST - Polyamine transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO1 PE=1 SV=1
0.0 [1..586] [1..586]
gi|9801985, gi|7... - gi|9801985|gb|AAF99573.1|AF188621_1 fluconazole resistance protein [Candida albicans], gi|76573588|d...
gi|68469252, gi|... - gi|77022662|ref|XP_888775.1| hypothetical protein CaO19_6577 [Candida albicans SC5314], gi|68470277|...
0.0 [9..584] [41..607]
SPCC569.05c - spermidine family transporter
YQO5_SCHPO - Uncharacterized transporter C569.05c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC5...
1.0E-94 [24..583] [1..573]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDHSPISNK ENHLLPSDSS RSSSSDMHST GTTGTTGVEP VDFTGEGAKY TTATEGNGGA  60
   61 DLAIQRTTTM NSAAESEVNI TRRLTKILTG SVNEPDRVEV DYTNCAPMGG DRPYPPSLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRDLYEVTFD GPNDPLHPFN WPMKKKVLLC LVLCLDSIAI AMCSSIFASA VPQICEIYHV  60
   61 IEVVAILGIT LFVLGFAASP VIYAPLSELY GRKGVLVLSA FGFALFQFAV ATAENLQTIF 120
  121 ICRFFGGFIG AAPMAVVPAA FADMFDTNVR GKAIALFSLG VFVGPILSPV MGSYIAQRTT 180
  181 WRWLEYVVGC FASAVFVAIV LFFE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [365-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVTRPIIMLF VEPLLLFVTI YNSFVYGILY LLLEAYPLVF VEGYGFTENG ELPYIALIIG  60
   61 MMVCAAFIWY MDNDYLKRCR AKGKLVPEAR LYAMVIAGTV FPIGILWFCW TGYYPHKIHW 120
  121 MVPTVGGAFI GFGLMGIFLP CLNYIIESYL LLAASAVAAN TFMRSAFGAC FPLFAGYMFR 180
  181 GMGIGWAGLL LGLFAAAMIP VPLLFLKYGE SIRKKSKYAY AA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.30103
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.24937104052238 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
binding 1.01584233411372 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [324-364]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETHHPTILVN KAKQMRKQSN NWGIHAAHED VELSIKDIVQ K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.30103
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle