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View Structure Prediction Details

Protein: TFA2
Organism: Saccharomyces cerevisiae
Length: 328 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFA2.

Description E-value Query
Range
Subject
Range
gi|1174562, gi|6... - gi|607956|gb|AAA62664.1| transcription factor TFIIE, small subunit, gi|1174562|sp|P36145.2|T2EB_YEAS...
0.0 [1..328] [1..328]
T2EB_SCHPO - Transcription initiation factor IIE subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
tfa2 - transcription factor TFIIE beta subunit Tfa2
9.0E-92 [62..325] [15..281]
gi|1834288 - gi|1834288|dbj|BAA19123.1| S.pombe TFA2 homolog [Schizosaccharomyces pombe]
5.0E-78 [109..325] [1..220]
CE26813 - transcription intiation factor TFIIE-BETA status:Confirmed UniProt:Q20776 protein_id:CAA91336.2
1.0E-76 [47..324] [7..288]
gi|157071405, gi... - gi|164426610|ref|XP_957548.2| hypothetical protein NCU03909 [Neurospora crassa OR74A], gi|157071405|...
gi|16945428 - gi|16945428|emb|CAB91686.2| related to transcription initiation factor IIE, beta subunit [Neurospora...
2.0E-74 [50..326] [3..299]
GTF2E2 - general transcription factor IIE, polypeptide 2, beta 34kDa
gi|55630478, gi|... - gi|55630478|ref|XP_519695.1| PREDICTED: general transcription factor IIE, polypeptide 2, beta 34kDa ...
gi|208966362 - gi|208966362|dbj|BAG73195.1| general transcription factor IIE, polypeptide 2, beta 34kDa [synthetic ...
8.0E-66 [47..325] [7..285]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
2.0E-65 [47..325] [7..285]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNRDPLLA NLNAFKSKVK SAPVIAPAKV GQKKTNDTVI TIDGNTRKRT ASERAQENTL  60
   61 NSAKNPVLVD IKKEAGSNSS NAISLDDDDD DEDFGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [97-187]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSKKVRPGS IAAAALQANQ TDISKSHDSS KLLWATEYIQ KKGKPVLVNE LLDYLSMKKD  60
   61 DKVIELLKKL DRIEFDPKKG TFKYLSTYDV H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1d8jA_
Description: The central core domain of TFIIE beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.67074370996647 bayes_pls_golite062009
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 4.84466441605416 bayes_pls_golite062009
nucleic acid binding 4.57954522145536 bayes_pls_golite062009
transcription factor activity 4.12685284895733 bayes_pls_golite062009
binding 4.05190810999633 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
sequence-specific DNA binding 2.3918869755162 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.82365519759474 bayes_pls_golite062009
RNA polymerase activity 1.82365519759474 bayes_pls_golite062009
protein binding 0.961087148890615 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
nucleotidyltransferase activity 0.237727660028553 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.157471576785569 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.0360186926687502 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [188-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSELLKLLR SQVTFKGISC KDLKDGWPQC DETINQLEED SKILVLRTKK DKTPRYVWYN  60
   61 SGGNLKCIDE EFVKMWENVQ LPQFAELPRK LQDLGLKPAS VDPATIKRQT KRVEVKKKRQ 120
  121 RKGKITNTHM TGILKDYSHR V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle