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View Structure Prediction Details

Protein: ALY1
Organism: Saccharomyces cerevisiae
Length: 915 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALY1.

Description E-value Query
Range
Subject
Range
ALY1 - Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin...
ALY1_YEAST - Arrestin-related trafficking adapter 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=A...
0.0 [1..915] [1..915]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [12..904] [9..981]
ARRB1_RAT - Beta-arrestin-1 OS=Rattus norvegicus GN=Arrb1 PE=1 SV=1
4.0E-87 [191..551] [35..394]
ARRB1_BOVIN - Beta-arrestin-1 OS=Bos taurus GN=ARRB1 PE=1 SV=1
1.0E-86 [191..551] [35..394]
ARRB1 - arrestin, beta 1
gi|208967645 - gi|208967645|dbj|BAG72468.1| arrestin, beta 1 [synthetic construct]
2.0E-86 [191..551] [35..394]
ARRS_LITPI - S-arrestin OS=Lithobates pipiens PE=2 SV=1
7.0E-84 [191..555] [38..381]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQFNTENDT VAPVFPMEQD INAAPDAVPL VQTTTLQVFV KLAEPIVFLK GFETNGLSEI  60
   61 APSILRGSLI VRVLKPNKLK SISITFKGIS RTEWPEGIPP KREEFSDVET VVNHTWPFYQ 120
  121 ADDGMNSFTL EHHSSNNSSN RPSMSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [147-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDYLLEKSGA SVYIPPTAEP PKDNSNLSLD AYERNSLSSD NLSNKPVSSD VSHDDSKLLA  60
   61 IQKTPLPSSS RRGSVPANFH GNSLSPHTFI SDLFTKTFSN SGATPSPEQE DNYLTPSKDS 120
  121 KEVFIFRPGD YIYTFEQPIS QSYPE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [299-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVEYKLSIDI ERFGAFKSTI HTQLPIKVVR L

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [517-572]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQLCSHANTL LPSYESHFQY CDEDGNFAPA ADQQNYASHH DSNIFFPKEV LSSPVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.522879
Match: 1jsyA_
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.637053679668866 bayes_pls_golite062009
protein binding 0.29496902337062 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [292-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIKANFG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [330-516]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSDGSVEETE AIAISKDWKD LLHYDVVIFS KEIVLNAFLP IDFHFAPLDK VTLHRIRIYL  60
   61 TESMEYTCNS NGNHEKARRL EPTKKFLLAE HNGPKLPHIP AGSNPLKAKN RGNILLDEKS 120
  121 GDLVNKDFQF EVFVPSKFTN SIRLHPDTNY DKIKAHHWIK ICLRLSKKYG DNRKHFEISI 180
  181 DSPIHIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.522879
Match: 1jsyA_
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [573-729]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPNVQKMNIR IPSDLPVVRN RAESVKKSKS DNTSKKNDQS SNVFASKQLV ANIYKPNQIP  60
   61 RELTSPQALP LSPITSPILN YQPLSNSPPP DFDFDLAKRG AADSHAIPVD PPSYFDVLKA 120
  121 DGIELPYYDT SSSKIPELKL NKSRETLASI EEDSFNG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.221 0.228 cytoplasm d.211.1 Ankyrin repeat
View Download 0.448 N/A N/A a.126.1 Serum albumin-like

Predicted Domain #5
Region A:
Residues: [730-915]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WSQIDDLSDE DDNDGDIASG FNFKLSTSAP SENVNSHTPI LQSLNMSLDG RKKNRASLHA  60
   61 TSVLPSTIRQ NNQHFNDINQ MLGSSDEDAF PKSQSLNFNK KLPILKINDN VIQSNSNSNN 120
  121 RVDNPEDTVD SSVDITAFYD PRMSSDSKFD WEVSKNHVDP AAYSVNVASE NRVLDDFKKA 180
  181 FREKRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.448 a.126.1 Serum albumin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle