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View Structure Prediction Details

Protein: JEN1
Organism: Saccharomyces cerevisiae
Length: 616 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JEN1.

Description E-value Query
Range
Subject
Range
JEN1 - Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is dere...
JEN1_YEAST - Carboxylic acid transporter protein homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
0.0 [1..616] [1..616]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1
0.0 [97..610] [19..563]
gi|16080636, gi|... - gi|2636109|emb|CAB15600.1| ywtG [Bacillus subtilis subsp. subtilis str. 168], gi|16080636|ref|NP_391...
gi|7446721, gi|1... - pir||E70070 metabolite transport protein homolog ywtG - Bacillus subtilis, gi|1894771|emb|CAB07473.1...
0.0 [139..574] [7..443]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSITDEKI SGEQQQPAGR KLYYNTSTFA EPPLVDGEGN PINYEPEVYN PDHEKLYHNP  60
   61 SLPAQSIQDT RDDELLERVY SQDQGV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.210 a.77.1 DEATH domain

Predicted Domain #2
Region A:
Residues: [87-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYEEDEEDKP NLSAASIKSY ALTRFTSLLH IHEFSWENVN PIPELRKMTW QNWNYFFMGY  60
   61 FAWLSAAWAF FCVSVSVAPL AELYDRPTKD ITWGLGLVLF VRSAGAVIFG LWTDKSSRKW 120
  121 PYITCLFLFV IAQLCTPWCD TYEKFLGVRW ITGIAMGGIY GCASATAIED APVKARSFLS 180
  181 GLFFSAYAMG FIFAIIFYRA FGYFRDDGWK ILFWFSIFLP ILLIFWRLLW P

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [361-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQKYWLLFAY LVVLLVGPNY LTHASQDLLP TMLRAQLGLS KDAVTVIVVV TNIGAICGGM  60
   61 IFGQFMEVTG RRLGLLIACT MGGCFTYPAF MLRSEKAILG AGFMLYFCVF GVWGILPIHL 120
  121 AELAPADARA LVAGLSYQLG NLASAAASTI ETQLADRYPL ERDASGAVIK EDYAKVMAIL 180
  181 TGSVFIFTFA CVFVGHEKF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.0
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transporter activity 3.3426261924492 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.29689809004391 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.15783210522667 bayes_pls_golite062009
ion transmembrane transporter activity 1.94035843948137 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
cation transmembrane transporter activity 1.5181741634556 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
binding 1.01584233411372 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [318-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETKYFTKVLK ARKLILSDAV KANGGEPLPK ANFKQKMVSM KRT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [560-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRDLSSPVMK KYINQVEEYE ADGLSISDIV EQKTECASVK MIDSNVSKTY EEHIETV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.0
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle