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View Structure Prediction Details

Protein: HAP4
Organism: Saccharomyces cerevisiae
Length: 554 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAP4.

Description E-value Query
Range
Subject
Range
gi|3763 - gi|3763|emb|CAA34707.1| unnamed protein product [Saccharomyces cerevisiae]
0.0 [1..554] [1..554]

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Predicted Domain #1
Region A:
Residues: [1-216]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAKTFLLQA SASRPRSNHF KNEHNNIPLA PVPIAPNTNH HNNSSLEFEN DGSKKKKKSS  60
   61 LVVRTSKHWV LPPRPRPGRR SSSHNTLPAN NTNNILNVGP NSRNSSNNNN NNNIISNRKQ 120
  121 ASKEKRKIPR HIQTIDEKLI NDSNYLAFLK FDDLENEKFH SSASSISSPS YSSPSFSSYR 180
  181 NRKKSEFMDD ESCTDVETIA AHNSLLTKNH HIDSSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [217-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVHAPPTKKS KLNDFDLLSL SSTSSSATPV PQLTKDLNMN LNFHKIPHKA SFPDSPADFS  60
   61 PADSVSLIRN HSLPTNLQVK DKIEDLNEIK FFNDFEKLEF FNKYAKVNTN NDVNENNDLW 120
  121 NSYLQSMDDT TGKNSGNYQQ VDNDDNMSLL NLPILEETVS SGQDDKVEPD EEDIWNYLPS 180
  181 SSSQQEDSSR ALKKNTNSEK ANIQAKNDET YLFLQDQDES ADSHHHDELG SEITLADNKF 240
  241 SYLPPTLEEL MEEQDCNNGR SFKNFMFSND TGIDGSAGTD DDYTKVLKSK KISTSKSNAN 300
  301 LYDLNDNNND ATATNELDQS SFIDDLDEDV DFLKVQVF

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.19
Match: 1iu4A
Description: Microbial transglutaminase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.50041094056334 bayes_pls_golite062009
transcription regulator activity 2.1624285999321 bayes_pls_golite062009
DNA binding 1.71473164736198 bayes_pls_golite062009
nucleic acid binding 1.65531829577581 bayes_pls_golite062009
hydrolase activity 1.50020630844645 bayes_pls_golite062009
transcription factor activity 1.00650665223823 bayes_pls_golite062009
catalytic activity 0.995453662223124 bayes_pls_golite062009
cysteine-type peptidase activity 0.892482498372301 bayes_pls_golite062009
protein binding 0.734893176227364 bayes_pls_golite062009
transporter activity 0.711763418431272 bayes_pls_golite062009
transmembrane transporter activity 0.455021528561131 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.222404916967017 bayes_pls_golite062009
substrate-specific transporter activity 0.140464985591688 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0410131027210778 bayes_pls_golite062009
pyrophosphatase activity 0.00374274471493652 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle