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View Structure Prediction Details

Protein: VPS25
Organism: Saccharomyces cerevisiae
Length: 202 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS25.

Description E-value Query
Range		 Subject
Range
gi|151945167 - gi|151945167|gb|EDN63418.1| vacuolar sorting protein [Saccharomyces cerevisiae YJM789]
gi|190409575 - gi|190409575|gb|EDV12840.1| vacuolar protein sorting protein 25 [Saccharomyces cerevisiae RM11-1a]
VPS25 - Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into...
VPS25_YEAST - Vacuolar protein-sorting-associated protein 25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
 3.0E-74 [1..202] [1..202]
VPS25_MOUSE - Vacuolar protein-sorting-associated protein 25 OS=Mus musculus GN=Vps25 PE=1 SV=1
gi|55716005 - gb|AAH86063.1| Unknown (protein for MGC:98421) [Xenopus laevis]
tr|G3HLY6|G3HLY6... - Vacuolar protein-sorting-associated protein 25 OS=Cricetulus griseus GN=I79_011730 PE=4 SV=1
 1.0E-58 [5..199] [8..175]
ENSMMUT000000030... - null, null
CCDS11438.1_1 - null
ENSPTRT00000016956 - null
VPS25 - vacuolar protein sorting 25 homolog (S. cerevisiae)
 4.0E-58 [5..199] [8..175]
VPS25_SCHPO - Vacuolar protein-sorting-associated protein 25 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
vps25 - ESCRT II complex subunit Vps25
 8.0E-55 [4..202] [3..173]
VPS25_ARATH - Vacuolar protein sorting-associated protein 25 OS=Arabidopsis thaliana GN=VPS25 PE=1 SV=1
 1.0E-54 [4..200] [9..176]
gi|16945422 - gi|16945422|emb|CAD11782.1| conserved hypothetical protein [Neurospora crassa]
gi|164426597, gi... - gi|164426597|ref|XP_957537.2| hypothetical protein NCU03898 [Neurospora crassa OR74A], gi|157071400|...
 1.0E-54 [5..196] [36..220]
vps-25 - status:Confirmed UniProt:Q9U354 protein_id:CAB04889.2
 1.0E-53 [5..202] [14..183]
gi|14582210 - gi|14582210|gb|AAK69405.1|AF274570_1 P protein [Paramecium primaurelia]
 9.0E-41 [14..190] [41..191]

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Predicted Domain #1
Region A:
Residues: [1-115] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALPPVYSF PPLYTRQPNS LTRRQQISTW IDIISQYCKT KKIWYMSVDG TVINDNELDS  60
   61 GSTDNDDSKK ISKNLFNNED IQRSVSQVFI DEIWSQMTKE GKCLPIDQSG RRSSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.35380365970626 bayes_pls_golite062009
transferase activity 1.0863867010063 bayes_pls_golite062009
molecular transducer activity 0.968719315363638 bayes_pls_golite062009
signal transducer activity 0.968719315363638 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
structure-specific DNA binding 0.217544912085963 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [116-202] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTTTRYFILW KSLDSWASLI LQWFEDSGKL NQVITLYELS EGDETVNWEF HRMPESLLYY  60
   61 CLKPLCDRNR ATMLKDENDK VIAIKVV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle