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View Structure Prediction Details

Protein: CBF1
Organism: Saccharomyces cerevisiae
Length: 351 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CBF1.

Description E-value Query
Range
Subject
Range
CBF1_YEAST - Centromere-binding protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CBF1 PE=1 S...
CBF1 - Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including ME...
8.0E-58 [1..351] [1..351]
USF2_MOUSE - Upstream stimulatory factor 2 OS=Mus musculus GN=Usf2 PE=1 SV=1
USF2_RAT - Upstream stimulatory factor 2 OS=Rattus norvegicus GN=Usf2 PE=1 SV=2
6.0E-42 [17..334] [19..346]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-41 [17..334] [19..346]
USF2 - upstream transcription factor 2, c-fos interacting
2.0E-41 [17..334] [19..346]
IPI:IPI00990983.... - Uncharacterized protein OS=Mus musculus GN=Usf2, Tax_Id=10090 Gene_Symbol=Usf2 Uncharacterized prote...
gi|11994804 - gi|11994804|dbj|BAB19965.1| USF2 splicing variant-1 [Rattus norvegicus]
5.0E-38 [17..334] [19..319]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLANNNKL STEDEEIHSA RKRGYNEEQN YSEARKKQRD QGLLSQESND GNIDSALLSE  60
   61 GATLKGTQSQ YESGLTSNKD EKGSDDEDAS VAEAAVAATV NYTDLIQGQE DSSDAHTSNQ 120
  121 TNANGEHKDS LNGERAITPS NEGVKPNTSL EGMTSSPMES TQQSKNDM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [169-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIPLAEHDRG PEHQQDDEDN DDADIDLKKD ISMQPGRRGR KPTTLATTDE WKKQRKDSHK  60
   61 EVERRRRENI NTAINVLSDL LPVRESSKAA ILACAAEYIQ KLKETDEANI EKWTLQKLLS 120
  121 EQNASQLASA NEKLQEELGN AYKEIEYMKR VLRKEGIEYE DMHTHKKQEN ERKSTRSDNP 180
  181 HEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1hloA_
Description: Max protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.58879320178546 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.94414084000081 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle