YRC Public Data Repository - Protein Structure Prediction

Protein:	TES1
Organism:	Saccharomyces cerevisiae
Length:	349 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TES1.

Description	E-value	Query Range	Subject Range
TES1 - Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty ac... PTE1_YEAST - Peroxisomal acyl-coenzyme A thioester hydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...	0.0	[1..349]	[1..349]
gi\|15076214 - gi\|15076214\|emb\|CAC47767.1\| Probable acyl-CoA thioesterase II [Sinorhizobium meliloti 1021] gi\|15966941 - gi\|15966941\|ref\|NP_387294.1\| acyl-CoA thioesterase II [Sinorhizobium meliloti 1021]	4.0E-91	[7..338]	[10..289]
gi\|25304482 - pir\|\|AC2915 acyl-CoA thioesterase II [imported] - Agrobacterium tumefaciens (strain C58, Dupont) gi\|17741270, gi\|... - gi\|17936631\|ref\|NP_533421.1\| acyl-CoA thioesterase II [Agrobacterium tumefaciens str. C58], gi\|17741...	5.0E-91	[2..338]	[5..289]
gi\|254715963 - gi\|254715963\|ref\|ZP_05177774.1\| acyl-CoA thioesterase II [Brucella ceti M13/05/1] gi\|25304483 - pir\|\|AI3272 acyl-CoA thioesterase II (EC 3.1.2.-) [imported] - Brucella melitensis (strain 16M) gi\|254713686 - gi\|254713686\|ref\|ZP_05175497.1\| acyl-CoA thioesterase II [Brucella ceti M644/93/1] gi\|254708890 - gi\|254708890\|ref\|ZP_05170701.1\| acyl-CoA thioesterase II [Brucella pinnipedialis B2/94] gi\|254707574 - gi\|254707574\|ref\|ZP_05169402.1\| acyl-CoA thioesterase II [Brucella pinnipedialis M163/99/10] gi\|254700542 - gi\|254700542\|ref\|ZP_05162370.1\| acyl-CoA thioesterase II [Brucella suis bv. 5 str. 513] gi\|17986450, gi\|... - gi\|17986450\|ref\|NP_539084.1\| acyl-CoA thioesterase II [Brucella melitensis 16M], gi\|17982047\|gb\|AAL5...	3.0E-89	[7..338]	[14..294]
ACOT8 - acyl-CoA thioesterase 8	6.0E-89	[13..342]	[30..313]
gi\|199603069, gi... - gi\|200390624\|ref\|ZP_03217235.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|194450134, gi... - gi\|194450134\|ref\|YP_002044499.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serov... gi\|197243013, gi... - gi\|197264758\|ref\|ZP_03164832.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|16418972, gi\|... - gi\|16763845\|ref\|NP_459460.1\| acyl-CoA thioesterase II [Salmonella typhimurium LT2], gi\|16418972\|gb\|A... gi\|168240295, gi... - gi\|205340194\|gb\|EDZ26958.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serovar He... gi\|194443130, gi... - gi\|194443130\|ref\|YP_002039708.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serov... gi\|205330834, gi... - gi\|205330834\|gb\|EDZ17598.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serovar 4,... lcl\|NC_016856.1_... - [gene=tesB] [protein=acyl-CoA thioesterase II] [protein_id=YP_005236162.1] [location=complement(5229...	6.0E-88	[7..338]	[4..283]
gi\|213425477 - gi\|213425477\|ref\|ZP_03358227.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|213583912 - gi\|213583912\|ref\|ZP_03365738.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|213619060 - gi\|213619060\|ref\|ZP_03372886.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|213650355 - gi\|213650355\|ref\|ZP_03380408.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|213023868 - gi\|213023868\|ref\|ZP_03338315.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|213418932 - gi\|213418932\|ref\|ZP_03351998.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|29142783, gi\|... - gi\|29142783\|ref\|NP_806125.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serovar T... gi\|16759445 - gi\|16759445\|ref\|NP_455062.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serovar T... gi\|25304477, gi\|... - gi\|25304477\|pir\|\|AD0560 acyl-CoA thioesterase II [imported] - Salmonella enterica subsp. enterica se... gi\|213859428 - gi\|213859428\|ref\|ZP_03385132.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova... gi\|214000477 - gi\|214000477\|ref\|ZP_03411212.1\| acyl-CoA thioesterase II [Salmonella enterica subsp. enterica serova...	1.0E-87	[7..338]	[4..283]
TESB_ECOLI - (P0AGG2) Acyl-CoA thioesterase II (EC 3.1.2.-) (TEII) TESB_ECO57 - (P0AGG3) Acyl-CoA thioesterase II (EC 3.1.2.-) (TEII)	2.0E-87	[7..338]	[3..282]
gi\|75194673, gi\|... - gi\|75194673\|ref\|ZP_00704743.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli HS], gi\|157159979\|re... gi\|169887873, gi... - gi\|170080038\|ref\|YP_001729358.1\| acyl-CoA thioesterase II [Escherichia coli str. K-12 substr. DH10B]... gi\|194428990, gi... - gi\|75209791\|ref\|ZP_00709993.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli B171], gi\|194428990\|... gi\|170682584, gi... - gi\|170682584\|ref\|YP_001742597.1\| acyl-CoA thioesterase II [Escherichia coli SMS-3-5], gi\|170520302\|g... gi\|83587092, gi\|... - gi\|83587092\|ref\|ZP_00925722.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli 101-1], gi\|194437391... gi\|195936016 - gi\|195936016\|ref\|ZP_03081398.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4024] gi\|75189521, gi\|... - gi\|75189521\|ref\|ZP_00702788.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli E24377A], gi\|1571585... gi\|208806091, gi... - gi\|208806091\|ref\|ZP_03248428.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4206], gi\|... gi\|75257902, gi\|... - gi\|75257902\|ref\|ZP_00729380.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli E22], gi\|193064190\|r... gi\|208731929, gi... - gi\|208815281\|ref\|ZP_03256460.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4045], gi\|... gi\|188490147, gi... - gi\|75514576\|ref\|ZP_00736831.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli 53638], gi\|188494948... gi\|208737304, gi... - gi\|208823111\|ref\|ZP_03263429.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4042], gi\|... gi\|75228531 - gi\|75228531\|ref\|ZP_00715165.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli B7A] gi\|209396532, gi... - gi\|209396532\|ref\|YP_002269102.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4115], gi... gi\|193067719, gi... - gi\|75239051\|ref\|ZP_00723033.1\| COG1946: Acyl-CoA thioesterase [Escherichia coli E110019], gi\|1930677... gi\|209917669, gi... - gi\|209917669\|ref\|YP_002291753.1\| acyl-CoA thioesterase II [Escherichia coli SE11], gi\|209910928\|dbj\|... gi\|168754558, gi... - gi\|189358080\|gb\|EDU76499.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4401], gi\|1687... gi\|189369049, gi... - gi\|189369049\|gb\|EDU87465.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4501], gi\|1687... gi\|168768408, gi... - gi\|189362396\|gb\|EDU80815.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4486], gi\|1687... gi\|168777149, gi... - gi\|187767548\|gb\|EDU31392.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4196], gi\|1687... gi\|168778946, gi... - gi\|189002813\|gb\|EDU71799.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4076], gi\|1687... gi\|83570154, gi\|... - gi\|83570154\|ref\|ZP_00921600.1\| COG1946: Acyl-CoA thioesterase [Shigella dysenteriae 1012], gi\|194432... gi\|189373511, gi... - gi\|189373511\|gb\|EDU91927.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC869], gi\|16878... gi\|189379377, gi... - gi\|189379377\|gb\|EDU97793.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC508], gi\|16879... gi\|169756087, gi... - gi\|170021159\|ref\|YP_001726113.1\| acyl-CoA thioesterase II [Escherichia coli ATCC 8739], gi\|169756087... gi\|217320984, gi... - gi\|217324763\|ref\|ZP_03440847.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. TW14588], gi... gi\|218359787, gi... - gi\|218553019\|ref\|YP_002385932.1\| acyl-CoA thioesterase II [Escherichia coli IAI1], gi\|218359787\|emb\|... gi\|218693915, gi... - gi\|218693915\|ref\|YP_002401582.1\| acyl-CoA thioesterase II [Escherichia coli 55989], gi\|218350647\|emb... gi\|218698636, gi... - gi\|218698636\|ref\|YP_002406265.1\| acyl-CoA thioesterase II [Escherichia coli IAI39], gi\|218368622\|emb... gi\|218430833, gi... - gi\|218703736\|ref\|YP_002411255.1\| acyl-CoA thioesterase II [Escherichia coli UMN026], gi\|218430833\|em... EG10995 - acyl-CoA thioesterase 2 / Acyl-CoA thioesterase 2 TESB_ECO57 - Acyl-CoA thioesterase 2 OS=Escherichia coli O157:H7 GN=tesB PE=3 SV=2 TESB_ECOLI - Acyl-CoA thioesterase 2 (EC 3.1.2.-) (Acyl-CoA thioesterase II) (TEII) - Escherichia coli gi\|15800182, gi\|... - gi\|15800182\|ref\|NP_286194.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 EDL933], gi\|12513317... EG10995 - acyl-CoA thioesterase 2 / Acyl-CoA thioesterase 2 gi\|168747871, gi... - gi\|188017608\|gb\|EDU55730.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. EC4113], gi\|1687... gi\|254591036, gi... - gi\|254791636\|ref\|YP_003076473.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. TW14359], g... gi\|73854509, gi\|... - gi\|74311032\|ref\|YP_309451.1\| acyl-CoA thioesterase II [Shigella sonnei Ss046], gi\|73854509\|gb\|AAZ872... gi\|253972423, gi... - gi\|254160522\|ref\|YP_003043630.1\| acyl-CoA thioesterase II [Escherichia coli B str. REL606], gi\|25397... gi\|85674592, gi\|... - gi\|89107322\|ref\|AP_001102.1\| acyl-CoA thioesterase II [Escherichia coli str. K-12 substr. W3110], gi... gi\|253325601, gi... - gi\|254287326\|ref\|YP_003053074.1\| acyl-CoA thioesterase II [Escherichia coli BL21(DE3)], gi\|253976633... gi\|124530296, gi... - gi\|124530296\|ref\|ZP_01701015.1\| acyl-CoA thioesterase II [Escherichia coli B], gi\|124499321\|gb\|EAY46... gi\|242376234, gi... - gi\|251783961\|ref\|YP_002998265.1\| hypothetical protein B21_00408 [Escherichia coli BL21], gi\|24237623... gi\|238899740, gi... - gi\|238899740\|ref\|YP_002925536.1\| acyl-CoA thioesterase II [Escherichia coli BW2952], gi\|238859928\|gb... gi\|13359963, gi\|... - gi\|15829760\|ref\|NP_308533.1\| acyl-CoA thioesterase II [Escherichia coli O157:H7 str. Sakai], gi\|1335...	2.0E-87	[7..338]	[4..283]

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Predicted Domain #1

Region A:
Residues: [1-349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASKMAMSN LEKILELVPL SPTSFVTKYL PAAPVGSKGT FGGTLVSQSL LASLHTVPLN  60
   61 FFPTSLHSYF IKGGDPRTKI TYHVQNLRNG RNFIHKQVSA YQHDKLIFTS MILFAVQRSK 120
  121 EHDSLQHWET IPGLQGKQPD PHRYEEATSL FQKEVLDPQK LSRYASLSDR FQDATSMSKY 180
  181 VDAFQYGVME YQFPKDMFYS ARHTDELDYF VKVRPPITTV EHAGDESSLH KHHPYRIPKS 240
  241 ITPENDARYN YVAFAYLSDS YLLLTIPYFH NLPLYCHSFS VSLDHTIYFH QLPHVNNWIY 300
  301 LKISNPRSHW DKHLVQGKYF DTQSGRIMAS VSQEGYVVYG SERDIRAKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	195.29073
Match:	1c8uA_
Description:	Thioesterase II (TesB)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.60197973503923	bayes_pls_golite062009
CoA hydrolase activity	2.3187640589669	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.14159464719086	bayes_pls_golite062009
thiolester hydrolase activity	1.14125301545576	bayes_pls_golite062009
catalytic activity	0.74605540351792	bayes_pls_golite062009
binding	0.358549779743531	bayes_pls_golite062009
hydrolase activity	0.093543122203219	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [131-349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPGLQGKQPD PHRYEEATSL FQKEVLDPQK LSRYASLSDR FQDATSMSKY VDAFQYGVME  60
   61 YQFPKDMFYS ARHTDELDYF VKVRPPITTV EHAGDESSLH KHHPYRIPKS ITPENDARYN 120
  121 YVAFAYLSDS YLLLTIPYFH NLPLYCHSFS VSLDHTIYFH QLPHVNNWIY LKISNPRSHW 180
  181 DKHLVQGKYF DTQSGRIMAS VSQEGYVVYG SERDIRAKF

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	7.51
Match:	1c8uA
Description:	Thioesterase II (TesB)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.09910961810984	bayes_pls_golite062009
CoA hydrolase activity	1.78895388806948	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07218515999697	bayes_pls_golite062009
catalytic activity	0.713153177522975	bayes_pls_golite062009
thiolester hydrolase activity	0.68445696143302	bayes_pls_golite062009
binding	0.425102971682545	bayes_pls_golite062009
hydrolase activity	0.0388706889258174	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: