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View Structure Prediction Details

Protein: MRS1
Organism: Saccharomyces cerevisiae
Length: 363 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRS1.

Description E-value Query
Range
Subject
Range
gi|3988 - gi|3988|emb|CAA29053.1| unnamed protein product [Saccharomyces cerevisiae]
gi|151943180 - gi|151943180|gb|EDN61515.1| protein required for the splicing of two mitochondrial group I introns (...
0.0 [1..363] [1..363]
MRS1_SACPA - Mitochondrial RNA-splicing protein MRS1 OS=Saccharomyces paradoxus GN=MRS1 PE=4 SV=1
MRS1_SACDO - Mitochondrial RNA-splicing protein MRS1 OS=Saccharomyces douglasii GN=MRS1 PE=4 SV=1
0.0 [1..363] [1..363]
cce1 - mitochondrial cruciform cutting endonuclease Cce1
CCE1_SCHPO - Cruciform cutting endonuclease 1, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 2484...
0.004 [73..218] [42..190]

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Predicted Domain #1
Region A:
Residues: [1-69]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPKNITRSV IPAIDLYCRK ANFKTLKSLS MILGSKKEWY DTKKAPLRTF LVSRCGIFEQ  60
   61 LRGRLVEDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.752 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.751 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.710 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.742 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.677 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.643 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.640 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.585 a.2.7 tRNA-binding arm
View Download 0.535 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.521 a.4.5 "Winged helix" DNA-binding domain
View Download 0.501 a.59.1 PAH2 domain
View Download 0.467 a.24.17 Group V grass pollen allergen
View Download 0.443 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.436 a.7.6 Ribosomal protein S20
View Download 0.432 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.431 f.14.1 Voltage-gated potassium channels
View Download 0.406 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.400 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.399 a.16.1 S15/NS1 RNA-binding domain
View Download 0.391 g.2.2 Neurotoxin B-IV
View Download 0.387 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.372 f.17.1 F1F0 ATP synthase subunit C
View Download 0.359 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.357 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.348 a.29.4 RecG, N-terminal domain
View Download 0.334 a.24.4 Hemerythrin
View Download 0.328 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.326 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.322 c.47.1 Thioredoxin-like
View Download 0.307 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.305 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.301 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.294 a.60.1 SAM/Pointed domain
View Download 0.290 a.1.1 Globin-like
View Download 0.284 a.11.1 Acyl-CoA binding protein
View Download 0.283 a.64.1 Saposin
View Download 0.278 a.4.8 Ribosomal protein S18
View Download 0.276 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.274 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.268 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.268 a.64.1 Saposin
View Download 0.265 a.60.8 HRDC-like
View Download 0.264 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.263 a.112.1 Description not found.
View Download 0.257 a.4.1 Homeodomain-like
View Download 0.255 a.4.5 "Winged helix" DNA-binding domain
View Download 0.248 d.50.3 PI-Pfui intein middle domain
View Download 0.246 a.36.1 Signal peptide-binding domain
View Download 0.244 a.144.1 PABC (PABP) domain
View Download 0.239 a.150.1 Anti-sigma factor AsiA
View Download 0.239 a.74.1 Cyclin-like
View Download 0.237 a.49.1 C-terminal domain of B transposition protein
View Download 0.233 d.141.1 Ribosomal protein L6
View Download 0.232 a.50.1 Anaphylotoxins (complement system)
View Download 0.231 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.226 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.225 a.61.1 Retroviral matrix proteins
View Download 0.223 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.218 a.4.1 Homeodomain-like
View Download 0.218 a.2.7 tRNA-binding arm
View Download 0.216 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.216 d.58.8 Viral DNA-binding domain
View Download 0.216 c.47.1 Thioredoxin-like
View Download 0.215 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.214 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.214 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.208 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.207 a.28.1 ACP-like
View Download 0.206 a.4.5 "Winged helix" DNA-binding domain
View Download 0.205 a.46.1 Methionine synthase domain
View Download 0.205 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.205 a.2.3 Chaperone J-domain
View Download 0.204 f.13.1 Family A G protein-coupled receptor-like
View Download 0.201 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain

Predicted functions:

Term Confidence Notes
nuclease activity 2.26556994009539 bayes_pls_golite062009
2.00836055708423 bayes_pls_golite062009
ribonuclease activity 1.78000986678433 bayes_pls_golite062009
exoribonuclease activity 1.32264233824256 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.27522285482764 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
transcription regulator activity 1.20586272399219 bayes_pls_golite062009
nucleic acid binding 1.15524113948715 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.05288004668073 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.99953538134208 bayes_pls_golite062009
exonuclease activity 0.967966366451269 bayes_pls_golite062009
DNA binding 0.943022297191079 bayes_pls_golite062009
binding 0.925646122805083 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.830848153280868 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.681014317532767 bayes_pls_golite062009
endonuclease activity 0.635517699603511 bayes_pls_golite062009
3'-5' exonuclease activity 0.4571735090405 bayes_pls_golite062009
transcription factor activity 0.350780284864953 bayes_pls_golite062009
RNA binding 0.239100354404122 bayes_pls_golite062009
protein binding 0.035326007863533 bayes_pls_golite062009
endoribonuclease activity 0.016619833072142 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [70-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVNLFSVFLT NDSFSFCKMT VDDKFNTSLV DWQKIPFDST FATDRRQNIS LLPVDTLFAT  60
   61 EKIISILGVS PNMTNLVSIE RERSDLVDFN CKLQSNILEH LLYAKCQGVY VTSTNEKARL 120
  121 LAAVCNPEFI DTFWCELTPI RVSLKENPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1kcfA_
Description: Mitochondrial resolvase ydc2 N-terminal domain; Mitochondrial resolvase ydc2 catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [219-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISVPREYQMY DPVVRATIKE VVTKRLLRSA FDNDIDPLMC LHLDKGWKLK FPILSSTTGL  60
   61 NFSLKDCLSL DTGKDASDMT EVFLATMESS KVLRTYSNLV DIVMKDNGRL DSGVLKQFND 120
  121 YVKQEKLNLQ HFQAGSSKFL KGAKI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.491 a.142.1 PTS-regulatory domain, PRD
View Download 0.262 a.24.14 FAT domain of focal adhesion kinase
View Download 0.422 a.118.11 Cytochrome c oxidase subunit E
View Download 0.261 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.359 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.256 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.251 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.237 d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.225 a.22.1 Histone-fold
View Download 0.221 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.217 a.118.1 ARM repeat
View Download 0.208 a.1.1 Globin-like
View Download 0.206 a.118.8 TPR-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle