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View Structure Prediction Details

Protein: QNS1
Organism: Saccharomyces cerevisiae
Length: 714 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for QNS1.

Description E-value Query
Range		 Subject
Range
NADSYN1 - NAD synthetase 1
 0.0 [1..709] [1..703]
gi|207344678 - gi|207344678|gb|EDZ71741.1| YHR074Wp-like protein [Saccharomyces cerevisiae AWRI1631]
NADE_YEAST - Glutamine-dependent NAD(+) synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=QN...
gi|151944019 - gi|151944019|gb|EDN62312.1| glutamine-dependent NAD synthetase [Saccharomyces cerevisiae YJM789]
QNS1 - Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid ade...
 0.0 [1..714] [1..714]
NADE_MOUSE - Glutamine-dependent NAD(+) synthetase OS=Mus musculus GN=Nadsyn1 PE=1 SV=1
gi|40644110 - gi|40644110|emb|CAC83797.1| NH3-dependent NAD+ synthetase like protein [Mus musculus domesticus]
 0.0 [1..707] [1..701]
NADE_SCHPO - Putative glutamine-dependent NAD(+) synthetase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
SPCC553.02 - glutamine-dependent NAD(+) synthetase
 0.0 [1..704] [1..698]
CG9940-PA, CG994... - This gene is referred to in FlyBase by the symbol Dmel\CG9940 (CG9940, FBgn0030512). It is a protein...
 0.0 [1..701] [1..696]
NADE_ARATH - Glutamine-dependent NAD(+) synthetase OS=Arabidopsis thaliana GN=At1g55090 PE=2 SV=1
 0.0 [3..700] [2..693]
CE18521 - status:Confirmed UniProt:Q9XXK6 protein_id:CAA18773.1
 0.0 [3..707] [6..703]
NAE2_THEMA, NADE... - (Q9X0Y0) Probable glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hyd...
NADE2_THEMA - Probable glutamine-dependent NAD(+) synthetase OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DS...
 0.0 [1..675] [1..572]
gi|25500547 - pir||G97029 nH(3)-dependent NAD(+) synthetase [imported] - Clostridium acetobutylicum
gi|15894337, gi|... - gi|15894337|ref|NP_347686.1| NAD synthetase [Clostridium acetobutylicum ATCC 824], gi|15023963|gb|AA...
 0.0 [3..678] [4..625]
NADE_AQUAE - Probable glutamine-dependent NAD(+) synthetase OS=Aquifex aeolicus GN=nadE PE=3 SV=1
NADE_AQUAE - Probable glutamine-dependent NAD(+) synthetase OS=Aquifex aeolicus (strain VF5) GN=nadE PE=3 SV=1
 0.0 [4..678] [1..558]

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Predicted Domain #1
Region A:
Residues: [1-313] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHLITLATC NLNQWALDFE GNRDRILQSI KIAKERGARL RVGPELEITG YGCLDHFLEN  60
   61 DVCLHSWEMY AQIIKNKETH GLILDIGMPV LHKNVRYNCR LLSLDGEILF IRPKIWLAND 120
  121 GNYREMRFFT PWMKPGVVED FILPPEIQKV TGQRLVPFGD AVINSLDTCI GTETCEELFT 180
  181 PQSPHIAMSL DGVEIMTNSS GSHHELRKLN KRLDLILNAT KRCGGVYLYA NQRGCDGDRL 240
  241 YYDGCALIAI NGTIVAQGSQ FSLDDVEVVT ATVDLEEVRS YRAAVMSRGL QASLAEIKFK 300
  301 RIDIPVELAL MTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1f89A_
Description: hypothetical protein yl85
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.8930848757764 bayes_pls_golite062009
catalytic activity 1.64442398754697 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.35962310800332 bayes_pls_golite062009
binding 1.19055167016953 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [314-658] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFDPTVCPTK VREPFYHSPE EEIALGPACW MWDYLRRCNG TGFFLPLSGG IDSCATAMIV  60
   61 HSMCRLVTDA AQNGNEQVIK DVRKITRSGD DWIPDSPQDL ASKIFHSCFM GTENSSKETR 120
  121 NRAKDLSNAI GSYHVDLKMD SLVSSVVSLF EVATGKKPIY KIFGGSQIEN LALQNIQARL 180
  181 RMVLSYLFAQ LLPWVRGIPN SGGLLVLGSA NVDECLRGYL TKYDCSSADI NPIGGISKTD 240
  241 LKRFIAYASK QYNMPILNDF LNATPTAELE PMTKDYVQSD EIDMGMTYEE LGVFGYLRKV 300
  301 EKCGPYSMFL KLLHQWSPKL TPRQISEKVK RFFFFYAINR HKQTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 133.27013
Match: 1ee1A_
Description: NH3-dependent NAD+-synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [659-714] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPSYHAEQY SPEDNRFDLR PFLINPRFPW ASRKIDEVVE QCEAHKGSTL DIMSID

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle