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View Structure Prediction Details

Protein: ERG11
Organism: Saccharomyces cerevisiae
Length: 530 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG11.

Description E-value Query
Range		 Subject
Range
C71BV_ARATH - Cytochrome P450 71B34 OS=Arabidopsis thaliana GN=CYP71B34 PE=2 SV=1
 0.0 [29..523] [4..496]
C93A1_SOYBN - 3,9-dihydroxypterocarpan 6A-monooxygenase OS=Glycine max GN=CYP93A1 PE=1 SV=1
 0.0 [25..530] [1..509]
C71A1_PERAE - Cytochrome P450 71A1 OS=Persea americana GN=CYP71A1 PE=1 SV=2
 0.0 [25..526] [1..502]
gi|12331298 - gi|12331298|emb|CAC24711.1| cytochrome P450 [Solanum tuberosum]
 0.0 [25..526] [1..499]

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Predicted Domain #1
Region A:
Residues: [1-157] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATKSIVGE ALEYVNIGLS HFLALPLAQR ISLIIIIPFI YNIVWQLLYS LRKDRPPLVF  60
   61 YWIPWVGSAV VYGMKPYEFF EECQKKYGDI FSFVLLGRVM TVYLGPKGHE FVFNAKLADV 120
  121 SAEAAYAHLT TPVFGKGVIY DCPNSRLMEQ KKFVKGA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [208-315] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASRSLLGKEM RAKLDTDFAY LYSDLDKGFT PINFVFPNLP LEHYRKRDHA QKAISGTYMS  60
   61 LIKERRKNND IQDRDLIDSL MKNSTYKDGV KMTDQEIANL LIGVLMGG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [381-410] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSLFRKVMKD MHVPNTSYVI PAGYHVLVSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 555.9794
Match: 1ea1A_
Description: Cytochrome p450 14 alpha-sterol demethylase (cyp51)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 5.03099580095037 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxygen binding 3.29945075872446 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
arachidonic acid monooxygenase activity 3.03830845324387 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.41884363121524 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.29989218606587 bayes_pls_golite062009
oxidoreductase activity 2.09151585300316 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
arachidonic acid epoxygenase activity 1.4220050618113 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.04852693766796 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.03699542179837 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 0.33710488712754 bayes_pls_golite062009
transition metal ion binding 0.22562022703652 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.169431271735966 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 0.167565425989292 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [158-207] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTKEAFKSYV PLIAEEVYKY FRDSKNFRLN ERTTGTIDVM VTQPEMTIFT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [316-380] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHTSAATSAW ILLHLAERPD VQQELYEEQM RVLDGGKKEL TYDLLQEMPL LNQTIKETLR  60
   61 MHHPL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [411-530] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYTHLRDEYF PNAHQFNIHR WNKDSASSYS VGEEVDYGFG AISKGVSSPY LPFGGGRHRC  60
   61 IGEHFAYCQL GVLMSIFIRT LKWHYPEGKT VPPPDFTSMV TLPTGPAKII WEKRNPEQKI 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 555.9794
Match: 1ea1A_
Description: Cytochrome p450 14 alpha-sterol demethylase (cyp51)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle