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View Structure Prediction Details

Protein: YHL039W
Organism: Saccharomyces cerevisiae
Length: 585 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHL039W.

Description E-value Query
Range
Subject
Range
YHL039W - Putative protein of unknown function; contains a SET-domain; predicted to be involved in ribosome bi...
EFM1_YEAST - Protein-lysine N-methyltransferase EFM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
0.0 [1..585] [1..585]
SETD4 - SET domain containing 4
3.0E-88 [2..435] [28..437]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-85 [6..432] [55..456]
SET10_SCHPO - Ribosomal lysine N-methyltransferase set10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
SPBC1709.13c - lysine methyltransferase
2.0E-84 [7..486] [1..462]
RBCMT_TOBAC - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
8.0E-84 [7..430] [57..455]
SETD4_MOUSE - SET domain-containing protein 4 OS=Mus musculus GN=Setd4 PE=2 SV=1
3.0E-83 [2..434] [27..435]

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Predicted Domain #1
Region A:
Residues: [1-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITQTELDNC LQWAQNNGAF IDPKISFRIT EDAGVSAFVN EKFSPKPDQA LIRVPETLLI  60
   61 TSQQALSEFS QAANERSLLN SVTQLYLSKL KFGTDAVHLK SFYKPYLDVL PLHLPQPYFW 120
  121 STDEVMNLHG TDVYLTMRDT LNKLVKEWRM LFQALSIEHS SQDKQFLSLF QENKDSAVVP 180
  181 LEQFCAHING CKLEDSEWNS FVAYLWSYCI FNSRAFPRVI LGRAGTDRTN LNEGFLYPIV 240
  241 DLLNHKNDVP VRWEMNEQNE LCFMSQTTTF SAQDELFNNY GNISNEKCLL NYGFWDSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
histone methyltransferase activity 6.20878333364554 bayes_pls_golite062009
protein methyltransferase activity 6.08778683840554 bayes_pls_golite062009
lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
N-methyltransferase activity 3.98411678860954 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 3.54138873512018 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.69428385009711 bayes_pls_golite062009
methyltransferase activity 2.33114816345072 bayes_pls_golite062009
binding 2.2675356705139 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.25175257044903 bayes_pls_golite062009
nucleic acid binding 1.79964884912488 bayes_pls_golite062009
chromatin binding 1.00298380074254 bayes_pls_golite062009
protein binding 0.938282161933492 bayes_pls_golite062009
transferase activity 0.653108419761009 bayes_pls_golite062009
catalytic activity 0.414641636618101 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [299-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKFDFSRLTL KLPSTLVSGL PVDFNKSGNF VTDDGETTIL QFSLKISEPL PPVLLALFAY  60
   61 LSKLKSEETP TVRSVLEGID QLTSVVSQRL LFYKNFKIKT SSTQKLRPHV IKLIKLYYQD 120
  121 NKKILNATTE KLSVLQKKIY SNNKEFSLSF KTIFKNDKIF ANSLLLVFGA INYEDLITKD 180
  181 CLNDALLLWI VKLINDKSNN QGGFIKQTFK EVSDSIVIEK EDVMEFLPFY KKYFPNLSER 240
  241 IPEIYSVGDW GIRQFIVADT AIDRLVWIRK SNKEPIFLMK KAYDLQI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle