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View Structure Prediction Details

Protein: BUB1
Organism: Saccharomyces cerevisiae
Length: 1021 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BUB1.

Description E-value Query
Range		 Subject
Range
gi|475128 - gi|475128|gb|AAA64894.1| protein kinase [Saccharomyces cerevisiae]
 0.0 [1..1021] [1..1021]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [36..1020] [48..1102]
gi|2981233 - gi|2981233|gb|AAC06259.1| mitotic checkpoint kinase Bub1 [Homo sapiens]
 0.0 [37..1020] [5..1085]
BUB1_MOUSE - Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Mus musculus GN=Bub1 PE=1 SV=1
 0.0 [36..1020] [4..1058]

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Predicted Domain #1
Region A:
Residues: [1-136] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLDLGSTVR GYESDKDTFP QSKGVSSSQK EQHSQLNQTK IAYEQRLLND LEDMDDPLDL  60
   61 FLDYMIWIST SYIEVDSESG QEVLRSTMER CLIYIQDMET YRNDPRFLKI WIWYINLFLS 120
  121 NNFHESENTF KYMFNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [137-211] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIGTKLSLFY EEFSKLLENA QFFLEAKVLL ELGAENNCRP YNRLLRSLSN YEDRLREMNI  60
   61 VENQNSVPDS RERLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1cxzB_
Description: Effector domain of the protein kinase pkn/prk1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.69172569316336 bayes_pls_golite062009
DNA binding 3.39869859972616 bayes_pls_golite062009
nucleic acid binding 3.23848471176801 bayes_pls_golite062009
binding 3.13193163173466 bayes_pls_golite062009
transcription factor activity 2.84890910865229 bayes_pls_golite062009
transcription factor binding 2.24654471792947 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.94402505264757 bayes_pls_golite062009
transcription activator activity 1.7419016121428 bayes_pls_golite062009
protein binding 1.73179783495389 bayes_pls_golite062009
kinase activity 1.65716179379575 bayes_pls_golite062009
protein kinase activity 1.65559891124729 bayes_pls_golite062009
sequence-specific DNA binding 1.49417707466137 bayes_pls_golite062009
protein heterodimerization activity 1.3916255846493 bayes_pls_golite062009
transporter activity 1.345463646363 bayes_pls_golite062009
protein dimerization activity 1.3011414258578 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.25717484863319 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.23751270866642 bayes_pls_golite062009
voltage-gated cation channel activity 1.2111783925162 bayes_pls_golite062009
transmembrane transporter activity 1.1928367617123 bayes_pls_golite062009
transcription repressor activity 1.16489293306631 bayes_pls_golite062009
substrate-specific transporter activity 1.10368550509667 bayes_pls_golite062009
voltage-gated potassium channel activity 1.09066951584628 bayes_pls_golite062009
voltage-gated ion channel activity 1.0878469536455 bayes_pls_golite062009
voltage-gated channel activity 1.08700038835943 bayes_pls_golite062009
cation channel activity 1.05127986997493 bayes_pls_golite062009
potassium channel activity 1.00381478626553 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.9754275279592 bayes_pls_golite062009
cation transmembrane transporter activity 0.97440822227802 bayes_pls_golite062009
transcription cofactor activity 0.97238321935796 bayes_pls_golite062009
gated channel activity 0.96773601513941 bayes_pls_golite062009
ion transmembrane transporter activity 0.94560998710422 bayes_pls_golite062009
ion channel activity 0.913028049156819 bayes_pls_golite062009
substrate-specific channel activity 0.86162931627036 bayes_pls_golite062009
transcription coactivator activity 0.85685043852877 bayes_pls_golite062009
passive transmembrane transporter activity 0.84703861081342 bayes_pls_golite062009
channel activity 0.84703861081342 bayes_pls_golite062009
histone acetyltransferase binding 0.806615474344071 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.7482723372563 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.63697280374462 bayes_pls_golite062009
transferase activity 0.511065872472486 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [212-452] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRLIYRTAPF FIRKFLTSSL MTDDKENRAN LNSNVGVGKS APNVYQDSIV VADFKSETER  60
   61 LNLNSSKQPS NQRLKNGNKK TSIYADQKQS NNPVYKLINT PGRKPERIVF NFNLIYPEND 120
  121 EEFNTEEILA MIKGLYKVQR RGKKHTEDYT SDKNRKKRKL DVLVERRQDL PSSQPPVVPK 180
  181 STRIEVFKDD DNPSQSTHHK NTQVQVQTTT SILPLKPVVD GNLAHETPVK PSLTSNASRS 240
  241 P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [453-589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVTAFSKDAI NEVFSMFNQH YSTPGALLDG DDTTTSKFNV FENFTQEFTA KNIEDLTEVK  60
   61 DPKQETVSQQ TTSTNETNDR YERLSNSSTR PEKADYMTPI KETTETDVVP IIQTPKEQIR 120
  121 TEDKKSGDNT ETQTQLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1jnuA_
Description: Photoreceptor phy3 flavin-binding domain, lov2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.69172569316336 bayes_pls_golite062009
DNA binding 3.39869859972616 bayes_pls_golite062009
nucleic acid binding 3.23848471176801 bayes_pls_golite062009
binding 3.13193163173466 bayes_pls_golite062009
transcription factor activity 2.84890910865229 bayes_pls_golite062009
transcription factor binding 2.24654471792947 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.94402505264757 bayes_pls_golite062009
transcription activator activity 1.7419016121428 bayes_pls_golite062009
protein binding 1.73179783495389 bayes_pls_golite062009
kinase activity 1.65716179379575 bayes_pls_golite062009
protein kinase activity 1.65559891124729 bayes_pls_golite062009
sequence-specific DNA binding 1.49417707466137 bayes_pls_golite062009
protein heterodimerization activity 1.3916255846493 bayes_pls_golite062009
transporter activity 1.345463646363 bayes_pls_golite062009
protein dimerization activity 1.3011414258578 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.25717484863319 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.23751270866642 bayes_pls_golite062009
voltage-gated cation channel activity 1.2111783925162 bayes_pls_golite062009
transmembrane transporter activity 1.1928367617123 bayes_pls_golite062009
transcription repressor activity 1.16489293306631 bayes_pls_golite062009
substrate-specific transporter activity 1.10368550509667 bayes_pls_golite062009
voltage-gated potassium channel activity 1.09066951584628 bayes_pls_golite062009
voltage-gated ion channel activity 1.0878469536455 bayes_pls_golite062009
voltage-gated channel activity 1.08700038835943 bayes_pls_golite062009
cation channel activity 1.05127986997493 bayes_pls_golite062009
potassium channel activity 1.00381478626553 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.9754275279592 bayes_pls_golite062009
cation transmembrane transporter activity 0.97440822227802 bayes_pls_golite062009
transcription cofactor activity 0.97238321935796 bayes_pls_golite062009
gated channel activity 0.96773601513941 bayes_pls_golite062009
ion transmembrane transporter activity 0.94560998710422 bayes_pls_golite062009
ion channel activity 0.913028049156819 bayes_pls_golite062009
substrate-specific channel activity 0.86162931627036 bayes_pls_golite062009
transcription coactivator activity 0.85685043852877 bayes_pls_golite062009
passive transmembrane transporter activity 0.84703861081342 bayes_pls_golite062009
channel activity 0.84703861081342 bayes_pls_golite062009
histone acetyltransferase binding 0.806615474344071 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.7482723372563 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.63697280374462 bayes_pls_golite062009
transferase activity 0.511065872472486 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [590-663] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTIQSSPFL TQPEPQAEKL LQTAEHSEKS KEHYPTIIPP FTKIKNQPPV IIENPLSNNL  60
   61 RAKFLSEISP PLFQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1a25A_
Description: C2 domain from protein kinase c (beta)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [664-691] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNTFYNYNQE LKMSSLLKKI HRVSRNEN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [751-770] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRLRKSTILK SIINASALHL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [781-1021] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YASQGTVLDL INLQREKAID GNGIMDEYLC MFITVELMKV LEKIHEVGII HGDLKPDNCM  60
   61 IRLEKPGEPL GAHYMRNGED GWENKGIYLI DFGRSFDMTL LPPGTKFKSN WKADQQDCWE 120
  121 MRAGKPWSYE ADYYGLAGVI HSMLFGKFIE TIQLQNGRCK LKNPFKRYWK KEIWGVIFDL 180
  181 LLNSGQASNQ ALPMTEKIVE IRNLIESHLE QHAENHLRNV ILSIEEELSH FQYKGKPSRR 240
  241 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [692-750] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNPIVDFKKT GDLYCIRGEL GEGGYATVYL AESSQGHLRA LKVEKPASVW EYYIMSQVE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [771-780] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLDESYLVLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle