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View Structure Prediction Details

Protein: CYS4
Organism: Saccharomyces cerevisiae
Length: 507 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYS4.

Description E-value Query
Range
Subject
Range
CBS_YEAST - Cystathionine beta-synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYS4 PE=1 SV...
CYS4 - Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the ...
0.0 [1..507] [1..507]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [8..507] [71..539]
gi|206600, gi|14... - gi|206600|gb|AAA42024.1| cystathionine beta-synthase, gi|158186659|ref|NP_036654.2| cystathionine-be...
0.0 [8..507] [71..540]
gi|20071821, gi|... - gi|30089694|ref|NP_835742.1| cystathionine-beta-synthase isoform 2 [Mus musculus], gi|26346589|dbj|B...
0.0 [8..507] [71..540]
gi|12653343 - gi|12653343|gb|AAH00440.1| CBS protein [Homo sapiens]
0.0 [8..507] [74..544]

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Predicted Domain #1
Region A:
Residues: [1-63]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSEQQADS RHNVIDLVGN TPLIALKKLP KALGIKPQIY AKLELYNPGG SIKDRIAKSM  60
   61 VEE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [157-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYNNMMNPEA HYFGTGREIQ RQLEDLNLFD NLRAVVAGAG TGGTISGISK YLKEQNDKIQ  60
   61 IVGADPFGSI LAQPENLNKT DITDYKVEGI GYDFVPQVLD RKLIDVWYKT DDKPSFKYAR 120
  121 QLISNEGVLV GGSSGSAFTA VVKYCEDHPE LTEDDVIVAI FPDSIRSYLT KFVDDEWLKK 180
  181 NNLWDDDVLA RFDSSKLEAS TTKYADVFGN AT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1095.9897
Match: 1jbqA_
Description: Cystathionine beta-synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine synthase activity 5.18562032111987 bayes_pls_golite062009
catalytic activity 2.38994231321972 bayes_pls_golite062009
lyase activity 1.87743897464083 bayes_pls_golite062009
cystathionine beta-synthase activity 1.4517088142802 bayes_pls_golite062009
tryptophan synthase activity 1.04832999357666 bayes_pls_golite062009
carbon-oxygen lyase activity 0.923824749425553 bayes_pls_golite062009
threonine synthase activity 0.727838845253199 bayes_pls_golite062009
ammonia-lyase activity 0.476674617721478 bayes_pls_golite062009
L-threonine ammonia-lyase activity 0.37325071016009 bayes_pls_golite062009
binding 0.362167982690705 bayes_pls_golite062009
carbon-nitrogen lyase activity 0.249761226675912 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [64-156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEASGRIHPS RSTLIEPTSG NTGIGLALIG AIKGYRTIIT LPEKMSNEKV SVLKALGAEI  60
   61 IRTPTAAAWD SPESHIGVAK KLEKEIPGAV ILD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1095.9897
Match: 1jbqA_
Description: Cystathionine beta-synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [369-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKDLHLKPVV SVKETAKVTD VIKILKDNGF DQLPVLTEDG KLSGLVTLSE LLRKLSINNS  60
   61 NNDNTIKGKY LDFKKLNNFN DVSSYNENKS GKKKFIKFDE NSKLSDLNRF FEKNSSAVIT 120
  121 DGLKPIHIVT KMDLLSYLA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.2
Match: 1b3oA
Description: Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle