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View Structure Prediction Details

Protein: ART5
Organism: Saccharomyces cerevisiae
Length: 586 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ART5.

Description E-value Query
Range
Subject
Range
ART5 - Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin...
ART5_YEAST - Arrestin-related trafficking adapter 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=A...
0.0 [1..586] [1..586]
CE09937 - status:Partially_confirmed UniProt:Q9GYT4 protein_id:AAF99937.1
7.0E-89 [143..582] [21..463]
gi|220950140 - gi|220950140|gb|ACL87613.1| CG18745-PA [synthetic construct]
CG18745-PA - This gene is referred to in FlyBase by the symbol Dmel\CG18745 (CG18745, FBgn0042102). It is a prote...
2.0E-71 [156..581] [30..399]
gi|18490372 - gi|18490372|gb|AAH22516.1| Arrestin domain containing 2 [Homo sapiens]
2.0E-70 [157..549] [38..402]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSLSSLSSS GGHSEQKERE RISYFDIRIN SPYKDIILIQ GSPLELSSIP LSGNLVISVK  60
   61 NEIVVKKISL RLVGRFKLEF LQVGRYKKNS SSLASLVKEK RKIFECYWDN LLVSSKGDVL 120
  121 VGGENA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [127-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENQHNSSSGR STSNQDMDTS GNAIFLSKRS LSSPVFNKII RRKTHSSHRK ILELPENGVT  60
   61 GTPFEGLREN ARSRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [202-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSNTLNNNS HSYSNRDGSG SSYLFLMKRG NYELPFNTML PPEVCETIEG LQSGSILYSF  60
   61 EAIIDGRQLW DT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [377-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYYAMKDSSA QIYDDEIA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [409-440]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKLDVDCPFT IPDNLKQITQ DCCLQDNLIR VM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1jsyA_
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.27724584326272 bayes_pls_golite062009
protein binding 1.04724707449453 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [274-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSVHTSPHG PIGSTSTSGN GMRTKNKIII KKFKYLRILR TLSMDNLAMQ EEISVGNTWR  60
   61 DKLQYETSIP SRAVPIGSTT PVKIKIFPFE KNIRLDRIEM ALI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [395-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMKITHLADF GPLT

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [441-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKLQVRILLQ RQVDG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1jsyA_
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [456-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYKNLEIKAQ LPMLLFISPH LPMKGRLVLF DKHDGKIHFR PGELVPLFLT TYPAQGLTPG  60
   61 VELNSTTTAH LALPQPPPNY HESTNDHLMP ALQPLGADSV VLTVPSYEQA QAQASASSYV 120
  121 TGSVPAYCDD D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle