YRC Public Data Repository - Protein Structure Prediction

Protein:	VAM7
Organism:	Saccharomyces cerevisiae
Length:	316 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VAM7.

Description	E-value	Query Range	Subject Range
VAM7_YEAST - Vacuolar morphogenesis protein 7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VAM7 PE... VAM7 - Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; function...	1.0E-69	[1..316]	[1..316]
SN25A_CARAU - Synaptosomal-associated protein 25-A OS=Carassius auratus GN=snap25a PE=2 SV=1	6.0E-37	[108..315]	[4..203]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	8.0E-37	[108..295]	[4..185]
gi\|117646124, gi... - gi\|117646124\|emb\|CAL38529.1\| hypothetical protein [synthetic construct], gi\|117645284\|emb\|CAL38108.1... gi\|126303706 - gi\|126303706\|ref\|XP_001374457.1\| PREDICTED: similar to synaptosomal associated protein-25 isoform 2 ... gi\|76632046 - gi\|76632046\|ref\|XP_869154.1\| PREDICTED: similar to synaptosomal-associated protein 25 isoform SNAP25... gi\|542156160\|ref... - PREDICTED: synaptosomal-associated protein 25 isoform X2 [Zonotrichia albicollis] ENSCJAT00000041990 - null gi\|122889819 - gi\|122889819\|emb\|CAM15065.1\| synaptosomal-associated protein 25 [Mus musculus] ENSOCUP00000018701 - pep:novel chromosome:oryCun2:4:25910953:26006153:-1 gene:ENSOCUG00000016119 transcript:ENSOCUT000000... ENSMMUG000000110... - null, null gi\|224047423 - gi\|224047423\|ref\|XP_002199098.1\| PREDICTED: synaptosomal-associated protein, 25kDa isoform 1 [Taenio... gi\|207080112 - gi\|207080112\|ref\|NP_001128960.1\| DKFZP459L0820 protein [Pongo abelii] gi\|73991295 - gi\|73991295\|ref\|XP_849677.1\| PREDICTED: similar to synaptosomal-associated protein 25 isoform SNAP25... gi\|56403740 - gi\|56403740\|emb\|CAI29660.1\| hypothetical protein [Pongo abelii] gi\|2135800, gi\|1... - gi\|54696236\|gb\|AAV38490.1\| synaptosomal-associated protein, 25kDa [Homo sapiens], gi\|4826423\|emb\|CAB... IPI:IPI00231420.... - Ensembl_locations(Chr-bp):None Splice isoform SNAP-25a of P13795, Tax_Id=10116 Splice Isoform SNAP-2... gi\|149733069 - gi\|149733069\|ref\|XP_001493177.1\| PREDICTED: similar to synaptosomal-associated protein 25 isoform 2 ... ENSPTRT00000024628 - null gi\|149640836 - gi\|149640836\|ref\|XP_001513821.1\| PREDICTED: similar to synaptosomal associated protein-25 isoform 2 ... gi\|521174 - gi\|521174\|gb\|AAA49070.1\| this product utilizes exon 5a [Gallus gallus] gi\|2116628 - gi\|2116628\|dbj\|BAA20151.1\| SNAP-25A [Rattus rattus]	9.0E-37	[108..315]	[4..205]
SNAP25 - synaptosomal-associated protein, 25kDa gi\|2116630 - gi\|2116630\|dbj\|BAA20152.1\| SNAP-25B [Rattus rattus] SNP25_PANTR - Synaptosomal-associated protein 25 OS=Pan troglodytes GN=SNAP25 PE=2 SV=1 CCDS13110.1_1 - null tr\|G1TAX9\|G1TAX9... - pep:novel chromosome:oryCun2:4:25910953:26006153:-1 gene:ENSOCUG00000016119 transcript:ENSOCUT000000... SNP25_RAT - Synaptosomal-associated protein 25 OS=Rattus norvegicus GN=Snap25 PE=1 SV=1 SNP25_MOUSE - Synaptosomal-associated protein 25 OS=Mus musculus GN=Snap25 PE=1 SV=1 gi\|73991287, gi\|... - gi\|73991287\|ref\|XP_859425.1\| PREDICTED: similar to synaptosomal-associated protein 25 isoform 13 [Ca... gi\|149640834 - gi\|149640834\|ref\|XP_001513799.1\| PREDICTED: similar to synaptosomal associated protein-25 isoform 1 ... gi\|208967516 - gi\|208967516\|dbj\|BAG73772.1\| synaptosomal-associated protein [synthetic construct] SNP25_BOVIN - Synaptosomal-associated protein 25 OS=Bos taurus GN=SNAP25 PE=1 SV=1 gi\|224047421 - gi\|224047421\|ref\|XP_002199106.1\| PREDICTED: synaptosomal-associated protein, 25kDa isoform 2 [Taenio... SNP25_CHICK - Synaptosomal-associated protein 25 OS=Gallus gallus GN=SNAP25 PE=1 SV=1 gi\|56342334\|dbj\|... - synaptosomal-associated 25kD protein [Pan troglodytes] SNP25_MACMU - Synaptosomal-associated protein 25 OS=Macaca mulatta GN=SNAP25 PE=2 SV=1 gi\|149733071 - gi\|149733071\|ref\|XP_001493159.1\| PREDICTED: similar to synaptosomal-associated protein 25 isoform 1 ... gi\|542156158\|ref... - PREDICTED: synaptosomal-associated protein 25 isoform X1 [Zonotrichia albicollis] gi\|126303704 - gi\|126303704\|ref\|XP_001374436.1\| PREDICTED: similar to synaptosomal associated protein-25 isoform 1 ...	1.0E-36	[108..315]	[4..205]
gi\|7271034 - gi\|7271034\|emb\|CAB77652.1\| hypothetical protein [Candida albicans]	4.0E-36	[30..313]	[14..290]
SNP25_TORMA - Synaptosomal-associated protein 25 OS=Torpedo marmorata GN=snap25 PE=2 SV=1	5.0E-36	[101..313]	[1..210]
gi\|18859395, gi\|... - gi\|3703100\|gb\|AAC64290.1\| synaptosome-associated protein 25.2 [Danio rerio], gi\|18859395\|ref\|NP_5715...	7.0E-36	[110..315]	[6..202]

Back

Predicted Domain #1

Region A:
Residues: [1-121]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANSVGKMS EKLRIKVDDV KINPKYVLYG VSTPNKRLYK RYSEFWKLKT RLERDVGSTI  60
   61 PYDFPEKPGV LDRRWQRRYD DPEMIDERRI GLERFLNELY NDRFDSRWRD TKIAQDFLQL 120
  121 S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	616.9897
Match:	1kmdA_
Description:	Vam7p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.45475353617729	bayes_pls_golite062009
phosphoinositide binding	2.08483770554381	bayes_pls_golite062009
protein binding	2.01416287650553	bayes_pls_golite062009
phospholipid binding	1.89416583268473	bayes_pls_golite062009
hydrolase activity	0.917504004061256	bayes_pls_golite062009
lipid binding	0.663652920263169	bayes_pls_golite062009
phosphatidylinositol-3-phosphate binding	0.643843925142106	bayes_pls_golite062009
catalytic activity	0.114035192741535	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [122-223]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPNVSQEKSQ QHLETADEVG WDEMIRDIKL DLDKESDGTP SVRGALRART KLHKLRERLE  60
   61 QDVQKKSLPS TEVTRRAALL RSLLKECDDI GTANIAQDRG RL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.0
Match:	1sfcC_
Description:	Synaptosomal-assosiated protein SNAP-25
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [224-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGVATSDNSS TTEVQGRTNN DLQQGQMQMV RDQEQELVAL HRIIQAQRGL ALEMNEELQT  60
   61 QNELLTALED DVDNTGRRLQ IANKKARHFN NSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.045757
Match:	1l4aD_
Description:	Synaptosomal-assosiated protein SNAP-25
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: