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View Structure Prediction Details

Protein: IME4
Organism: Saccharomyces cerevisiae
Length: 600 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IME4.

Description E-value Query
Range		 Subject
Range
IME4 - Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid...
IME4_YEAST - N6-adenosine-methyltransferase IME4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IME4...
 0.0 [1..600] [1..600]
CG5933-PA - This gene is referred to in FlyBase by the symbol Dmel\CG5933 (CG5933, FBgn0039139). It is a protein...
 0.0 [240..525] [318..589]
MTA70_ARATH - N6-adenosine-methyltransferase MT-A70-like OS=Arabidopsis thaliana GN=MTA PE=1 SV=2
 0.0 [240..544] [390..665]
MTA70_MOUSE - N6-adenosine-methyltransferase subunit METTL3 OS=Mus musculus GN=Mettl3 PE=1 SV=2
 0.0 [241..525] [296..571]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 4.0E-93 [241..544] [418..727]
gi|125584920, gi... - gi|50919731|ref|XP_470226.1| Unknown protein with similarity to methyltransferases and transcription...
 7.0E-87 [297..542] [473..733]
gi|10047331 - gi|10047331|dbj|BAB13453.1| KIAA1627 protein [Homo sapiens]
ENSPTRT00000030485 - null
 1.0E-65 [301..513] [156..384]

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Predicted Domain #1
Region A:
Residues: [1-295] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINDKLVHFL IQNYDDILRA PLSGQLKDVY SLYISGGYDD EMQKLRNDKD EVLQFEQFWN  60
   61 DLQDIIFATP QSIQFDQNLL VADRPEKIVY LDVFSLKILY NKFHAFYYTL KSSSSSCEEK 120
  121 VSSLTTKPEA DSEKDQLLGR LLGVLNWDVN VSNQGLPREQ LSNRLQNLLR EKPSSFQLAK 180
  181 ERAKYTTEVI EYIPICSDYS HASLLSTSVY IVNNKIVSLQ WSKISACQEN HPGLIECIQS 240
  241 KIHFIPNIKP QTDISLGDCS YLDTCHKLNT CRYIHYLQYI PSCLQERADR ETASE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [296-532] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKRIRSNVSI PFYTLGNCSA HCIKKALPAQ WIRCDVRKFD FRVLGKFSVV IADPAWNIHM  60
   61 NLPYGTCNDI ELLGLPLHEL QDEGIIFLWV TGRAIELGKE SLNNWGYNVI NEVSWIKTNQ 120
  121 LGRTIVTGRT GHWLNHSKEH LLVGLKGNPK WINKHIDVDL IVSMTRETSR KPDELYGIAE 180
  181 RLAGTHARKL EIFGRDHNTR PGWFTIGNQL TGNCIYEMDV ERKYQEFMKS KTGTSHT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
methyltransferase activity 3.68431317301075 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 3.60853685152199 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.91374296950366 bayes_pls_golite062009
DNA-methyltransferase activity 2.72106897862429 bayes_pls_golite062009
RNA methyltransferase activity 2.63941856307703 bayes_pls_golite062009
N-methyltransferase activity 2.62081022854657 bayes_pls_golite062009
protein methyltransferase activity 2.60624413031692 bayes_pls_golite062009
transferase activity 1.97261773840408 bayes_pls_golite062009
rRNA methyltransferase activity 1.85380504590369 bayes_pls_golite062009
histone methyltransferase activity 1.5770892133978 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 1.5743030926483 bayes_pls_golite062009
arginine N-methyltransferase activity 1.17774160785818 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 1.17774160785818 bayes_pls_golite062009
catalytic activity 1.16970557486814 bayes_pls_golite062009
tRNA methyltransferase activity 0.752031224323003 bayes_pls_golite062009
binding 0.749096536959959 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 0.663671542316122 bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity 0.378599327496302 bayes_pls_golite062009
rRNA (uridine) methyltransferase activity 0.283627597838594 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 0.24819970199694 bayes_pls_golite062009
RNA binding 0.145125818301729 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.113328595762489 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.0804008144859909 bayes_pls_golite062009
transcription regulator activity 0.0739385287924036 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.0390774859535424 bayes_pls_golite062009
DNA binding 0.029220083486074 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [533-600] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTKKIDKKQP SKLQQQHQQQ YWNNMDMGSG KYYAEAKQNP MNQKHTPFES KQQQKQQFQT  60
   61 LNNLYFAQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

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Created and Maintained by: Michael Riffle