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View Structure Prediction Details

Protein: TIP20
Organism: Saccharomyces cerevisiae
Length: 701 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIP20.

Description E-value Query
Range
Subject
Range
TIP20 - Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion ...
gi|151943666 - gi|151943666|gb|EDN61976.1| transport protein [Saccharomyces cerevisiae YJM789]
TIP20_YEAST - Protein transport protein TIP20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIP20 PE...
0.0 [1..701] [1..701]
MYH11_RABIT - Myosin-11 OS=Oryctolagus cuniculus GN=MYH11 PE=2 SV=2
0.001 [8..143] [1332..1468]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.001 [8..143] [1332..1468]
MYH11 - myosin, heavy chain 11, smooth muscle
gi|168273110 - gi|168273110|dbj|BAG10394.1| myosin-11 [synthetic construct]
0.002 [8..143] [1332..1468]
gi|10176794 - gi|10176794|dbj|BAB09933.1| kinesin-like protein [Arabidopsis thaliana]
0.003 [6..152] [218..361]

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Predicted Domain #1
Region A:
Residues: [1-164]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIDDLLNI NDRIKQVQNE RNELASKLQN LKQSLASNDT EVALSEVIAQ DIIEVGASVE  60
   61 GLEQLRAKYG DLQILNKLEK VAVQQTQMQA GVDKLDSFER QLDELAEQPP DQFTLDDVKA 120
  121 LHSKLTSVFA TVPQINNIDS QYAAYNKLKS KVTGKYNDVI IQRL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [190-246]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVGLVKCLRE NSTKLYQLSL LYLPLEEETQ NGDSERPLSR SNNNQEPVLW NFKSLAN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.22504663904848 bayes_pls_golite062009
binding 2.04447608076272 bayes_pls_golite062009
cytoskeletal protein binding 1.88229294781644 bayes_pls_golite062009
actin binding 0.92731255372235 bayes_pls_golite062009
actin filament binding 0.847123006562293 bayes_pls_golite062009
SNARE binding 0.309596137075689 bayes_pls_golite062009
syntaxin binding 0.214277649172074 bayes_pls_golite062009
protein complex binding 0.0466251755500114 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [165-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATNWSNTFDQ KLLEAQWDTQ KFAST

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [247-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNVRFTYHF HATSSSSKIE TYFQFLNDYL AENLYKCINI FHDDCNGLTK PVIHEQFINY  60
   61 VLQPIRDKVR STLFQNDLKT LIVLISQILA TDK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [340-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLLNSFHYHG LGLVSLISDE VWEKWINYEV EMANRQFINI TKNPEDFPKS SQNFVKLINK  60
   61 IYDYLEPFYD LDFDLLVRYK LMTCSLIFMN LTS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [433-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYLDYILTVD SLNETRTKEQ ELYQTMAKLQ HVNFVYRKIK SLSSNFIFIQ LTDIVNSTES  60
   61 KKYNSLFQNV ENDYEKAMST DMQNSIVHRI QKLLKETLRN YFKISTWSTL EMSVDENIGP 120
  121 SSVPSAELVN SINVLRRLIN KLDSMDIPLA ISLKVKNELL NVIVNYFTES ILKLNKFNQN 180
  181 GLNQFLHDFK SLSSILSL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [631-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSHATNYKCM SLHELVKILK LKYDPNNQQF LNPEYIKTGN FTSLKEAYSI KYLKDTKIQD  60
   61 ALYRIIYGNI L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle