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View Structure Prediction Details

Protein: TIP20
Organism: Saccharomyces cerevisiae
Length: 701 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIP20.

Description E-value Query
Range
Subject
Range
TIP20 - Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion ...
gi|151943666 - gi|151943666|gb|EDN61976.1| transport protein [Saccharomyces cerevisiae YJM789]
TIP20_YEAST - Protein transport protein TIP20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TIP20 PE...
0.0 [1..701] [1..701]
MYH11_RABIT - Myosin-11 OS=Oryctolagus cuniculus GN=MYH11 PE=2 SV=2
0.001 [8..143] [1332..1468]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.001 [8..143] [1332..1468]
MYH11 - myosin, heavy chain 11, smooth muscle
gi|168273110 - gi|168273110|dbj|BAG10394.1| myosin-11 [synthetic construct]
0.002 [8..143] [1332..1468]
gi|10176794 - gi|10176794|dbj|BAB09933.1| kinesin-like protein [Arabidopsis thaliana]
0.003 [6..152] [218..361]

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Predicted Domain #1
Region A:
Residues: [1-164]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIDDLLNI NDRIKQVQNE RNELASKLQN LKQSLASNDT EVALSEVIAQ DIIEVGASVE  60
   61 GLEQLRAKYG DLQILNKLEK VAVQQTQMQA GVDKLDSFER QLDELAEQPP DQFTLDDVKA 120
  121 LHSKLTSVFA TVPQINNIDS QYAAYNKLKS KVTGKYNDVI IQRL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [190-246]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVGLVKCLRE NSTKLYQLSL LYLPLEEETQ NGDSERPLSR SNNNQEPVLW NFKSLAN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.22504663904848 bayes_pls_golite062009
binding 2.04447608076272 bayes_pls_golite062009
cytoskeletal protein binding 1.88229294781644 bayes_pls_golite062009
actin binding 0.92731255372235 bayes_pls_golite062009
actin filament binding 0.847123006562293 bayes_pls_golite062009
SNARE binding 0.309596137075689 bayes_pls_golite062009
syntaxin binding 0.214277649172074 bayes_pls_golite062009
protein complex binding 0.0466251755500114 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [165-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATNWSNTFDQ KLLEAQWDTQ KFAST

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [247-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNVRFTYHF HATSSSSKIE TYFQFLNDYL AENLYKCINI FHDDCNGLTK PVIHEQFINY  60
   61 VLQPIRDKVR STLFQNDLKT LIVLISQILA TDK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [340-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLLNSFHYHG LGLVSLISDE VWEKWINYEV EMANRQFINI TKNPEDFPKS SQNFVKLINK  60
   61 IYDYLEPFYD LDFDLLVRYK LMTCSLIFMN LTS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [433-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYLDYILTVD SLNETRTKEQ ELYQTMAKLQ HVNFVYRKIK SLSSNFIFIQ LTDIVNSTES  60
   61 KKYNSLFQNV ENDYEKAMST DMQNSIVHRI QKLLKETLRN YFKISTWSTL EMSVDENIGP 120
  121 SSVPSAELVN SINVLRRLIN KLDSMDIPLA ISLKVKNELL NVIVNYFTES ILKLNKFNQN 180
  181 GLNQFLHDFK SLSSILSL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [631-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSHATNYKCM SLHELVKILK LKYDPNNQQF LNPEYIKTGN FTSLKEAYSI KYLKDTKIQD  60
   61 ALYRIIYGNI L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.628 a.39.1 EF-hand
View Download 0.490 c.47.1 Thioredoxin-like
View Download 0.695 a.4.1 Homeodomain-like
View Download 0.522 a.60.2 RuvA domain 2-like
View Download 0.469 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.456 a.3.1 Cytochrome c
View Download 0.456 d.58.1 4Fe-4S ferredoxins
View Download 0.455 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.451 a.28.1 ACP-like
View Download 0.450 d.57.1 DNA damage-inducible protein DinI
View Download 0.432 a.60.2 RuvA domain 2-like
View Download 0.409 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.404 d.50.3 PI-Pfui intein middle domain
View Download 0.404 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.394 a.4.1 Homeodomain-like
View Download 0.387 d.58.1 4Fe-4S ferredoxins
View Download 0.387 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.386 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.386 a.60.1 SAM/Pointed domain
View Download 0.376 a.4.5 "Winged helix" DNA-binding domain
View Download 0.372 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.370 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.335 a.4.5 "Winged helix" DNA-binding domain
View Download 0.332 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.323 d.75.1 tRNA splicing endonuclease EdnA, N-terminal domain
View Download 0.322 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.305 a.60.2 RuvA domain 2-like
View Download 0.304 d.58.7 RNA-binding domain, RBD
View Download 0.304 d.56.1 GroEL-intermediate domain like
View Download 0.301 a.39.4 Hypothetical protein MTH865
View Download 0.293 a.28.1 ACP-like
View Download 0.291 a.61.1 Retroviral matrix proteins
View Download 0.279 d.58.1 4Fe-4S ferredoxins
View Download 0.273 a.60.8 HRDC-like
View Download 0.272 d.58.17 Metal-binding domain
View Download 0.267 d.50.3 PI-Pfui intein middle domain
View Download 0.261 a.77.1 DEATH domain
View Download 0.253 a.60.2 RuvA domain 2-like
View Download 0.251 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.249 d.58.10 Acylphosphatase-like
View Download 0.247 a.4.1 Homeodomain-like
View Download 0.238 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.227 a.60.1 SAM/Pointed domain
View Download 0.222 a.4.5 "Winged helix" DNA-binding domain
View Download 0.215 a.39.1 EF-hand
View Download 0.211 c.47.1 Thioredoxin-like
View Download 0.209 a.130.1 Chorismate mutase II


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle