YRC Public Data Repository - Protein Structure Prediction

Protein:	HEM2
Organism:	Saccharomyces cerevisiae
Length:	342 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM2.

Description	E-value	Query Range	Subject Range
HEM2_SELMA - Delta-aminolevulinic acid dehydratase, chloroplastic OS=Selaginella martensii GN=HEMB PE=3 SV=1	0.0	[7..341]	[85..416]
HEM2_SPIOL - Delta-aminolevulinic acid dehydratase, chloroplastic OS=Spinacia oleracea GN=HEMB PE=1 SV=2	0.0	[7..341]	[101..431]
HEM21_ARATH - Delta-aminolevulinic acid dehydratase 1, chloroplastic OS=Arabidopsis thaliana GN=HEMB1 PE=2 SV=1	0.0	[7..341]	[97..428]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[7..341]	[68..400]
gi\|13560098 - gi\|13560098\|emb\|CAC36148.1\| ALA dehydratase [Fucus vesiculosus]	0.0	[10..341]	[98..422]
gi\|13560254 - gi\|13560254\|emb\|CAC36186.1\| ALA dehydratase [Odontella sinensis]	0.0	[15..341]	[88..409]
gi\|1041423 - gi\|1041423\|emb\|CAA63139.1\| aminolevulinate dehydratase [Hordeum vulgare subsp. vulgare] HEM2_HORVU - Delta-aminolevulinic acid dehydratase, chloroplastic OS=Hordeum vulgare GN=HEMB PE=2 SV=1	0.0	[7..340]	[93..423]
HEM2_SYNP7 - (P43087) Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) (Porphobilinogen synthase) (ALAD) (ALAD... gi\|1084166 - gi\|1084166\|pir\|\|S42531 hem B protein - Synechococcus sp	0.0	[6..339]	[2..326]
gi\|254851489, gi... - gi\|254851489\|ref\|ZP_05240839.1\| delta-aminolevulinic acid dehydratase [Vibrio cholerae MO10], gi\|254... gi\|254292249, gi... - gi\|254292249\|ref\|ZP_04963010.1\| delta-aminolevulinic acid dehydratase [Vibrio cholerae AM-19226], gi... gi\|153831355, gi... - gi\|153831355\|ref\|ZP_01984022.1\| delta-aminolevulinic acid dehydratase [Vibrio cholerae 623-39], gi\|1... gi\|227011893, gi... - gi\|75828053\|ref\|ZP_00757488.1\| COG0113: Delta-aminolevulinic acid dehydratase [Vibrio cholerae O395]... gi\|121730181, gi... - gi\|75814176\|ref\|ZP_00744804.1\| COG0113: Delta-aminolevulinic acid dehydratase [Vibrio cholerae V52],... gi\|227080341, gi... - gi\|227080341\|ref\|YP_002808892.1\| delta-aminolevulinic acid dehydratase [Vibrio cholerae M66-2], gi\|2... gi\|229508385, gi... - gi\|229508385\|ref\|ZP_04397889.1\| porphobilinogen synthase [Vibrio cholerae BX 330286], gi\|229354658\|g... gi\|229354051, gi... - gi\|229508934\|ref\|ZP_04398424.1\| porphobilinogen synthase [Vibrio cholerae B33], gi\|229354051\|gb\|EEO1... gi\|229515859, gi... - gi\|229515859\|ref\|ZP_04405317.1\| porphobilinogen synthase [Vibrio cholerae TMA 21], gi\|229347122\|gb\|E... gi\|15640137, gi\|... - gi\|9654504\|gb\|AAF93283.1\| delta-aminolevulinic acid dehydratase [Vibrio cholerae O1 biovar El Tor st... gi\|229346111, gi... - gi\|229517048\|ref\|ZP_04406494.1\| porphobilinogen synthase [Vibrio cholerae RC9], gi\|229346111\|gb\|EEO1... gi\|11269326 - pir\|\|G82363 delta-aminolevulinic acid dehydratase VC0105 [imported] - Vibrio cholerae (strain N16961... gi\|229525003, gi... - gi\|229525003\|ref\|ZP_04414408.1\| porphobilinogen synthase [Vibrio cholerae bv. albensis VL426], gi\|22... gi\|229606659, gi... - gi\|229606659\|ref\|YP_002877307.1\| porphobilinogen synthase [Vibrio cholerae MJ-1236], gi\|229369314\|gb...	0.0	[16..342]	[12..337]
hemB - hemB delta-aminolevulinic acid dehydratase 3084385:3085437 reverse MW:38416 gi\|4001680 - gi\|4001680\|dbj\|BAA35069.1\| porphobilinogen synthase [Rhodopseudomonas palustris] gi\|192291366, gi... - gi\|192291366\|ref\|YP_001991971.1\| Porphobilinogen synthase [Rhodopseudomonas palustris TIE-1], gi\|192...	0.0	[4..340]	[15..348]

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Predicted Domain #1

Region A:
Residues: [1-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHTAEFLETE PTEISSVLAG GYNHPLLRQW QSERQLTKNM LIFPLFISDN PDDFTEIDSL  60
   61 PNINRIGVNR LKDYLKPLVA KGLRSVILFG VPLIPGTKDP VGTAADDPAG PVIQGIKFIR 120
  121 EYFPELYIIC DVCLCEYTSH GHCGVLYDDG TINRERSVSR LAAVAVNYAK AGAHCVAPSD 180
  181 MIDGRIRDIK RGLINANLAH KTFVLSYAAK FSGNLYGPFR DAACSAPSNG DRKCYQLPPA 240
  241 GRGLARRALE RDMSEGADGI IVKPSTFYLD IMRDASEICK DLPICAYHVS GEYAMLHAAA 300
  301 EKGVVDLKTI AFESHQGFLR AGARLIITYL APEFLDWLDE EN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10141.0
Match:	1ylvA_
Description:	5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.67031204377352	bayes_pls_golite062009
porphobilinogen synthase activity	2.60788870678525	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	0.877814788710295	bayes_pls_golite062009
binding	0.584966797881465	bayes_pls_golite062009
carbon-carbon lyase activity	0.55793298895297	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.487442544994915	bayes_pls_golite062009
transaldolase activity	0.184100272651834	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.132814423759102	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: