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View Structure Prediction Details

Protein: PDR1
Organism: Saccharomyces cerevisiae
Length: 1068 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDR1.

Description E-value Query
Range
Subject
Range
gi|7706833 - gi|7706833|gb|AAD13897.2|S58126_111111 Unknown [Saccharomyces cerevisiae]
0.0 [1..1068] [1..1063]
UAY_EMENI - Positive regulator of purine utilization - Emericella nidulans (Aspergillus nidulans)
5.0E-91 [5..557] [27..538]
YBCB_SCHPO - Uncharacterized transcriptional regulatory protein C27B12.11c OS=Schizosaccharomyces pombe (strain 9...
SPBC27B12.11c - transcription factor
5.0E-36 [2..271] [237..497]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGLTPKNGV HIETGPDTES SADSSNFSTG FSGKIRKPRS KVSKACDNCR KRKIKCNGKF  60
   61 PCASCEIYSC ECTFSTRQGG ARIKNLHKTS LEGTTVQVKE ETDSSSTSFS N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.274545
Match: 1d66A_
Description: Gal4; CD2-Gal4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQRCTDGPCA VEQPTKFFEN FKLGGRSSGD NSGSDGKNDD DVNRNGFYED DSESQATLTS  60
   61 LQTTLKNLKE MAHLGTHVTS AIESIELQIS DLLKRWEPKV RTKELATTKF YPNKSIETQL 120
  121 MKNKYCDVVH LTRYAAWSNN KKDQDTSSQP LIDEIFGLYS PFQFLSLQGI GKCFQNYRSK 180
  181 SKCEIFPRTA KETIYIMLRF FDVCFHHINQ GCVSIANPLE NYLQKMNLLP STPSSISSAG 240
  241 SPNTAHTKSH VALVINHLPQ PFVRNITGIS NSELLSEMNN DISMFGILLK MLDMHKNSYQ 300
  301 NFLMEITSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [421-574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSVAKNTQSI DVLQEFIHYC QAGEALIALC YSYYNSTLYN YVDFTCDITH LEQLLYFLDL  60
   61 LFWLSEIYGF EKVLNVAVHF VSRVGLSRWE FYVGLDENFA ERRRNLWWKA FYFEKTLASK 120
  121 LGYPSNIDDS KINCLLPKNF RDVGFLDNRD FIEN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.405 0.252 response to drug a.7.6 Ribosomal protein S20
View Download 0.562 0.012 transcription activator activity a.118.8 TPR-like
View Download 0.433 0.005 DNA binding a.60.9 lambda integrase-like, N-terminal domain
View Download 0.392 0.002 DNA binding a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.383 0.001 transcription activator activity a.63.1 Apolipophorin-III
View Download 0.373 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.373 N/A N/A a.26.1 4-helical cytokines
View Download 0.367 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.360 N/A N/A a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.351 N/A N/A a.39.3 Cloroperoxidase
View Download 0.336 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.302 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.292 N/A N/A c.55.1 Actin-like ATPase domain
View Download 0.285 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.267 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.265 N/A N/A c.53.1 Resolvase-like
View Download 0.263 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.262 N/A N/A a.26.1 4-helical cytokines
View Download 0.258 N/A N/A a.74.1 Cyclin-like
View Download 0.254 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.244 N/A N/A c.23.1 CheY-like
View Download 0.242 N/A N/A a.1.1 Globin-like
View Download 0.242 N/A N/A a.1.1 Globin-like
View Download 0.240 N/A N/A a.1.1 Globin-like
View Download 0.239 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.234 N/A N/A a.19.1 Fertilization protein
View Download 0.233 N/A N/A a.118.8 TPR-like
View Download 0.225 N/A N/A a.74.1 Cyclin-like
View Download 0.224 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.224 N/A N/A a.1.1 Globin-like
View Download 0.224 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.222 N/A N/A a.118.8 TPR-like
View Download 0.217 N/A N/A a.74.1 Cyclin-like
View Download 0.209 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.204 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.203 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #4
Region A:
Residues: [575-1068]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHLVRRSEAF DNMCISDLKY YGELAVLQIV SHFSSSVLFN EKFTSIRNTS KPSVVREKLL  60
   61 FEVLEIFNET EMKYDAIKEQ TGKLFDIAFS KDSTELKVSR EDKIMASKFV LFYEHHFCRM 120
  121 VNESDNIVAR LCVHRRPSIL IENLKIYLHK IYKSWTDMNK ILLDFDNDYS VYRSFAHYSI 180
  181 SCIILVSQAF SVAEFIKVND VVNMIRVFKR FLDIKIFSEN ETNEHVFNSQ SFKDYTRAFS 240
  241 FLTIVTRIML LAYGESSSTN LDVISKYIDE NAPDLKGIIE LVLDTNSCAY RFLLEPVQKS 300
  301 GFHLTVSQML KNRKFQEPLM SNEDNKQMKH NSGKNLNPDL PSLKTGTSCL LNGIESPQLP 360
  361 FNGRSAPSPV RNNSLPEFAQ LPSFRSLSVS DMINPDYAQP TNGQNNTQVQ SNKPINAQQQ 420
  421 IPTSVQVPFM NTNEINNNNN NNNNNKNNIN NINNNNSNNF SATSFNLGTL DEFVNNGDLE 480
  481 DLYSILWSDV YPDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [467-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DITHLEQLLY FLDLLFWLSE IYGFEKVLNV AVHFVSRVGL SRWEFYVGLD ENFAERRRNL  60
   61 WWKAFYFEKT LASKLGYPSN IDDSKINCLL P

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 17.420216
Match: PF04082.9
Description: No description for PF04082.9 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [558-798]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNFRDVGFLD NRDFIENVHL VRRSEAFDNM CISDLKYYGE LAVLQIVSHF SSSVLFNEKF  60
   61 TSIRNTSKPS VVREKLLFEV LEIFNETEMK YDAIKEQTGK LFDIAFSKDS TELKVSREDK 120
  121 IMASKFVLFY EHHFCRMVNE SDNIVARLCV HRRPSILIEN LKIYLHKIYK SWTDMNKILL 180
  181 DFDNDYSVYR SFAHYSISCI ILVSQAFSVA EFIKVNDVVN MIRVFKRFLD IKIFSENETN 240
  241 E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [799-1068]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVFNSQSFKD YTRAFSFLTI VTRIMLLAYG ESSSTNLDVI SKYIDENAPD LKGIIELVLD  60
   61 TNSCAYRFLL EPVQKSGFHL TVSQMLKNRK FQEPLMSNED NKQMKHNSGK NLNPDLPSLK 120
  121 TGTSCLLNGI ESPQLPFNGR SAPSPVRNNS LPEFAQLPSF RSLSVSDMIN PDYAQPTNGQ 180
  181 NNTQVQSNKP INAQQQIPTS VQVPFMNTNE INNNNNNNNN NKNNINNINN NNSNNFSATS 240
  241 FNLGTLDEFV NNGDLEDLYS ILWSDVYPDS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle