YRC Public Data Repository - Protein Structure Prediction

Protein:	BNA6
Organism:	Saccharomyces cerevisiae
Length:	295 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BNA6.

Description	E-value	Query Range	Subject Range
BNA6 - Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan... NADC_YEAST - Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Saccharomyces cerevisiae (strain ATCC 204... gi\|151940811 - gi\|151940811\|gb\|EDN59198.1\| quinolinate phosphoribosyl transferase [Saccharomyces cerevisiae YJM789]	2.0E-92	[1..295]	[1..295]
gi\|7449667 - pir\|\|S76136 hypothetical protein - Synechocystis sp. (strain PCC 6803) NADC_SYNY3 - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Synechocystis sp. (strain ATCC 2... NADC_SYNY3 - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Synechocystis sp. (strain PCC 68...	1.0E-83	[2..293]	[9..292]
NADC_METJA - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Methanocaldococcus jannaschii GN... NADC_METJA - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Methanocaldococcus jannaschii (s...	4.0E-83	[16..293]	[8..279]
gi\|18309378, gi\|... - gi\|18309378\|ref\|NP_561312.1\| nicotinate-nucleotide pyrophosphorylase [Clostridium perfringens str. 1...	3.0E-82	[11..292]	[3..273]
NADC_BACSU - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Bacillus subtilis GN=nadC PE=1 S... NADC_BACSU - Probable nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Bacillus subtilis (strain 168) G... gi\|221324251 - gi\|221324251\|ref\|ZP_03605545.1\| nicotinate-nucleotide pyrophosphorylase [Bacillus subtilis subsp. su... gi\|157850193, gi... - gi\|157850193\|gb\|ABV89931.1\| nicotinate-nucleotide pyrophosphorylase [Bacillus subtilis subsp. subtil... gi\|221315050 - gi\|221315050\|ref\|ZP_03596855.1\| nicotinate-nucleotide pyrophosphorylase [Bacillus subtilis subsp. su... gi\|221319970 - gi\|221319970\|ref\|ZP_03601264.1\| nicotinate-nucleotide pyrophosphorylase [Bacillus subtilis subsp. su...	4.0E-82	[14..293]	[6..274]
gi\|15622247, gi\|... - gi\|15921461\|ref\|NP_377130.1\| nicotinate-nucleotide pyrophosphorylase [Sulfolobus tokodaii str. 7], g...	1.0E-81	[13..293]	[5..273]
NADC_PSEAE - Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Pseudomonas aeruginosa (strain ATCC 15692... gi\|107099891 - gi\|107099891\|ref\|ZP_01363809.1\| hypothetical protein PaerPA_01000912 [Pseudomonas aeruginosa PACS2] NADC_PSEAE - Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Pseudomonas aeruginosa GN=nadC PE=3 SV=2	2.0E-81	[1..293]	[1..280]
gi\|15674399, gi\|... - gi\|15674399\|ref\|NP_268573.1\| nicotinate-nucleotide pyrophosphorylase [Streptococcus pyogenes M1 GAS]...	8.0E-81	[7..292]	[8..283]
gi\|50914407, gi\|... - gi\|50914407\|ref\|YP_060379.1\| nicotinate-nucleotide pyrophosphorylase [Streptococcus pyogenes MGAS103... gi\|71909984, gi\|... - gi\|71909984\|ref\|YP_281534.1\| nicotinate-nucleotide pyrophosphorylase [Streptococcus pyogenes MGAS500... gi\|134271864, gi... - gi\|139473617\|ref\|YP_001128333.1\| nicotinate-nucleotide pyrophosphorylase [Streptococcus pyogenes str... gi\|19748503, gi\|... - gi\|19748503\|gb\|AAL97947.1\| putative nicotinate-nucleotide pyrophosphorylase [Streptococcus pyogenes ...	8.0E-81	[7..292]	[8..283]
gi\|16930777 - gi\|16930777\|gb\|AAL32048.1\|AF439854_1 NadC [Vibrio vulnificus]	8.0E-81	[10..292]	[18..293]

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Predicted Domain #1

Region A:
Residues: [1-118]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVYEHLLPV NGAWRQDVTN WLSEDVPSFD FGGYVVGSDL KEANLYCKQD GMLCGVPFAQ  60
   61 EVFNQCELQV EWLFKEGSFL EPSKNDSGKI VVAKITGPAK NILLAERTAL NILSRSSG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [286-295]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIDFSLKLAH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	398.69897
Match:	1qapA_
Description:	Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain; Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate phosphoribosyltransferase activity	3.4096751090496	bayes_pls_golite062009
nicotinate-nucleotide diphosphorylase (carboxylating) activity	3.12788282156037	bayes_pls_golite062009
binding	1.58263447797054	bayes_pls_golite062009
catalytic activity	0.60409960326459	bayes_pls_golite062009
protein binding	0.502035039039958	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [119-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IATASHKIIS LARSTGYKGT IAGTRKTTPG LRRLEKYSML VGGCDTHRYD LS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [277-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSSIHQGTP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	398.69897
Match:	1qapA_
Description:	Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain; Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [171-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMVMLKDNHI WATGSITNAV KNARAVCGFA VKIEVECLSE DEATEAIEAG ADVIMLDNFK  60
   61 GDGLKMCAQS LKNKWNGKKH FLLECSGGLN LDNLEEYLCD DIDIYS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	398.69897
Match:	1qapA_
Description:	Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain; Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: