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View Structure Prediction Details

Protein: SHO1
Organism: Saccharomyces cerevisiae
Length: 367 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SHO1.

Description E-value Query
Range
Subject
Range
SHO1 - Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent fi...
SHO1_YEAST - High osmolarity signaling protein SHO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S...
0.0 [1..367] [1..367]
gi|7688244 - gi|7688244|emb|CAB89868.1| putative membrane protein [Kluyveromyces lactis]
1.0E-86 [21..361] [20..354]
SHO1_CYBJA - High osmolarity signaling protein SHO1 OS=Cyberlindnera jadinii GN=SHO1 PE=3 SV=1
2.0E-75 [23..360] [14..296]
gi|18072843 - gi|18072843|emb|CAC81238.1| SHO1 protein [Candida albicans]
9.0E-60 [23..360] [3..386]
MYO1F - myosin IF
6.0E-32 [133..359] [561..782]
gi|439821 - gi|439821|gb|AAB28755.1| cortactin, p80/p85 [mice, BALB/c 3T3 cells, Peptide, 546 aa]
1.0E-28 [144..358] [331..544]
gi|74225117, gi|... - gi|74225117|dbj|BAE38252.1| unnamed protein product [Mus musculus], gi|74223237|dbj|BAE40752.1| unna...
2.0E-28 [144..358] [294..507]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-28 [132..359] [879..1107]

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Predicted Domain #1
Region A:
Residues: [1-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISSKIRPT PRKPSRMATD HSFKMKKFYA DPFAISSISL AIVSWVIAIG GSISSASTNE  60
   61 SFPRFTWWGI VYQFLIICSL MLFYCFDLVD HYRIFITTSI AVAFVYNTNS ATNLVYADGP 120
  121 KKAAASAGVI LLSIINLIWI LYYGGDNASP TNRWIDSFSI KGIRPSPLEN SLHRARRRGN 180
  181 RNTTPYQNNV YNDAIRDSGY ATQFDGYPQQ QPSHTNYVSS TALAGFENTQ PNTSEAVNLH 240
  241 LNTLQQRINS ASN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [254-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKETNDNSNN QTNTNIGNTF DTDFSNGNTE TTMGDTLGLY SDIGDDNFIY KAKALYPYDA  60
   61 DDDDAYEISF EQNEILQVSD IEGRWWKARR ANGETGIIPS NYVQLIDGPE EMHR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.38764
Match: 1g83A_
Description: Fyn proto-oncogene tyrosine kinase, SH3 domain; Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.42916850671495 bayes_pls_golite062009
protein binding 2.08632303609243 bayes_pls_golite062009
cytoskeletal protein binding 1.69497236763657 bayes_pls_golite062009
signal transducer activity 1.34867629228264 bayes_pls_golite062009
molecular transducer activity 1.34867629228264 bayes_pls_golite062009
actin binding 0.75725452085414 bayes_pls_golite062009
receptor binding 0.351326788023913 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle