YRC Public Data Repository - Protein Structure Prediction

Protein:	ICP55
Organism:	Saccharomyces cerevisiae
Length:	511 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ICP55.

Description	E-value	Query Range	Subject Range
ICP55 - Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage ... gi\|190405641 - gi\|190405641\|gb\|EDV08908.1\| hypothetical protein SCRG_04554 [Saccharomyces cerevisiae RM11-1a] ICP55_YEAST - Intermediate cleaving peptidase 55 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ICP55...	0.0	[1..511]	[1..511]
gi\|83587696, gi\|... - gi\|83587696\|ref\|ZP_00926323.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli 101-1], gi\|19443678... gi\|170082468, gi... - gi\|170082468\|ref\|YP_001731788.1\| proline aminopeptidase P II [Escherichia coli str. K-12 substr. DH1... AMPP_ECOLI - Xaa-Pro aminopeptidase (EC 3.4.11.9) (X-Pro aminopeptidase) (Aminopeptidase P II) (APP-II) (Aminoacy... EG10697 - proline aminopeptidase P II / Proline aminopeptidase, homotetrameric; aminopeptidase P gi\|238902033, gi... - gi\|238902033\|ref\|YP_002927829.1\| proline aminopeptidase P II [Escherichia coli BW2952], gi\|238863278... EG10697 - proline aminopeptidase P II / Proline aminopeptidase, homotetrameric; aminopeptidase P gi\|216529\|dbj\|BA... - aminopeptidase P precursor [Escherichia coli] gi\|85675720, gi\|... - gi\|89109687\|ref\|AP_003467.1\| proline aminopeptidase P II [Escherichia coli str. K-12 substr. W3110],...	0.0	[65..495]	[4..435]
gi\|157831534, gi... - gi\|4699533\|pdb\|1JAW\| Chain , Aminopeptidase P From E. Coli Low Ph Form, gi\|157831534\|pdb\|1JAW\|A Ch...	0.0	[65..495]	[3..434]
gi\|13363251, gi\|... - gi\|15833033\|ref\|NP_311806.1\| proline aminopeptidase P II [Escherichia coli O157:H7 str. Sakai], gi\|1... gi\|13363251, gi\|... - gi\|15833033\|ref\|NP_311806.1\| proline aminopeptidase P II [Escherichia coli O157:H7], gi\|13363251\|dbj... gi\|209760450, gi... - pir\|\|G85946 proline aminopeptidase P II [imported] - Escherichia coli (strain O157:H7, substrain ED... gi\|15803443, gi\|... - gi\|15803443\|ref\|NP_289476.1\| proline aminopeptidase P II [Escherichia coli O157:H7 EDL933], gi\|12517... gi\|254794857, gi... - gi\|254794857\|ref\|YP_003079694.1\| proline aminopeptidase P II [Escherichia coli O157:H7 str. TW14359]... gi\|217326697, gi... - gi\|217326697\|ref\|ZP_03442780.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|195936526 - gi\|195936526\|ref\|ZP_03081908.1\| proline aminopeptidase P II [Escherichia coli O157:H7 str. EC4024] gi\|208733741, gi... - gi\|208812464\|ref\|ZP_03253793.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|208741670, gi... - gi\|208821547\|ref\|ZP_03261867.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4042], gi\|20... gi\|209398591, gi... - gi\|209398591\|ref\|YP_002272384.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4115], gi\|2... gi\|168775788, gi... - gi\|187768811\|gb\|EDU32655.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4196], gi\|168775... gi\|168778924, gi... - gi\|189003609\|gb\|EDU72595.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4076], gi\|168778... gi\|168785757, gi... - gi\|189373889\|gb\|EDU92305.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC869], gi\|1687857... gi\|189377684, gi... - gi\|189377684\|gb\|EDU96100.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC508], gi\|1688000... gi\|168747610, gi... - gi\|188017799\|gb\|EDU55921.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4113], gi\|168747... gi\|189358530, gi... - gi\|189358530\|gb\|EDU76949.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4401], gi\|168753... gi\|189369256, gi... - gi\|189369256\|gb\|EDU87672.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4501], gi\|168760... gi\|189363746, gi... - gi\|189363746\|gb\|EDU82165.1\| Xaa-Pro aminopeptidase [Escherichia coli O157:H7 str. EC4486], gi\|168766...	0.0	[65..496]	[4..436]
HGNC:28052\|Ensem... - aminopeptidase (aminopeptidase P) 3, putative gi\|109451798, gi... - gi\|109451798\|emb\|CAK54770.1\| dJ1057D18.1 [synthetic construct], gi\|109451220\|emb\|CAK54471.1\| dJ1057D... XPNPEP3 - X-prolyl aminopeptidase (aminopeptidase P) 3, putative	0.0	[39..492]	[40..500]
gi\|2773347 - gi\|2773347\|gb\|AAB96776.1\| aminopeptidase [Shigella flexneri]	0.0	[65..496]	[4..436]
gi\|213999421 - gi\|213999421\|ref\|ZP_03410156.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica ser... gi\|213646978 - gi\|213646978\|ref\|ZP_03377031.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica ser... gi\|213427303 - gi\|213427303\|ref\|ZP_03360053.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica ser... gi\|213418753 - gi\|213418753\|ref\|ZP_03351819.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica ser... gi\|16761839 - gi\|16761839\|ref\|NP_457456.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica serova... gi\|16504141, gi\|... - gi\|25289698\|pir\|\|AH0873 proline aminopeptidase II [imported] - Salmonella enterica subsp. enterica s... gi\|29143326, gi\|... - gi\|29143326\|ref\|NP_806668.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica serova... gi\|213162877 - gi\|213162877\|ref\|ZP_03348587.1\| proline aminopeptidase P II [Salmonella enterica subsp. enterica ser...	0.0	[65..496]	[1..433]
gi\|205331081, gi... - gi\|205331081\|gb\|EDZ17845.1\| Xaa-Pro aminopeptidase [Salmonella enterica subsp. enterica serovar 4,[5... gi\|16766359, gi\|... - gi\|16766359\|ref\|NP_461974.1\| proline aminopeptidase P II [Salmonella typhimurium LT2], gi\|16421609\|g... lcl\|NC_016856.1_... - [gene=pepP] [protein=proline aminopeptidase P II] [protein_id=YP_005239198.1] [location=complement(3...	0.0	[65..496]	[1..433]

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Predicted Domain #1

Region A:
Residues: [1-240]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHRINPVRF SMQSCQRYFS KLVSPLEQHK SNTFTNRVRI PIEAGQPLHE TRPFLIKSGE  60
   61 LTPGISALEY YERRIRLAET LPPKSCVILA GNDIQFASGA VFYPFQQEND LFYLSGWNEP 120
  121 NSVMILEKPT DSLSDTIFHM LVPPKDAFAE KWEGFRSGVY GVQEIFNADE SASINDLSKY 180
  181 LPKIINRNDF IYFDMLSTSN PSSSNFKHIK SLLDGSGNSN RSLNSIANKT IKPISKRIAE 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	663.9794
Match:	1az9__
Description:	Aminopeptidase P; Aminopeptidase P, C-terminal domain

Predicted Domain #2

Region A:
Residues: [241-511]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRKIKSPQEL RIMRRAGQIS GRSFNQAFAK RFRNERTLDS FLHYKFISGG CDKDAYIPVV  60
   61 ATGSNSLCIH YTRNDDVMFD DEMVLVDAAG SLGGYCADIS RTWPNSGKFT DAQRDLYEAV 120
  121 LNVQRDCIKL CKASNNYSLH DIHEKSITLM KQELKNLGID KVSGWNVEKL YPHYIGHNLG 180
  181 LDVHDVPKVS RYEPLKVGQV ITIEPGLYIP NEESFPSYFR NVGIRIEDDI AIGEDTYTNL 240
  241 TVEAVKEIDD LENVMQNGLS TKFEEDQVAP L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	663.9794
Match:	1az9__
Description:	Aminopeptidase P; Aminopeptidase P, C-terminal domain

Predicted functions:

Term	Confidence	Notes
peptidase activity	2.60615909541559	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	2.18503136472662	bayes_pls_golite062009
metallopeptidase activity	1.75829852010848	bayes_pls_golite062009
hydrolase activity	1.43646476372001	bayes_pls_golite062009
aminopeptidase activity	0.89399203910285	bayes_pls_golite062009
binding	0.762408229471586	bayes_pls_golite062009
exopeptidase activity	0.762255574851485	bayes_pls_golite062009
nucleic acid binding	0.352607952828331	bayes_pls_golite062009
catalytic activity	0.148551873544128	bayes_pls_golite062009
transcription regulator activity	0.0346092896934742	bayes_pls_golite062009
DNA binding	0.0315289262145955	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: