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View Structure Prediction Details

Protein: PCL6
Organism: Saccharomyces cerevisiae
Length: 420 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCL6.

Description E-value Query
Range
Subject
Range
PCL6 - Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; ...
gi|207345958 - gi|207345958|gb|EDZ72603.1| YER059Wp-like protein [Saccharomyces cerevisiae AWRI1631]
PCL6_YEAST - PHO85 cyclin-6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCL6 PE=1 SV=1
0.0 [1..420] [1..420]
gi|25493992, gi|... - gi|2982283|gb|AAC32127.1| PREG-like protein [Picea mariana], pir||T52062 PREG-like protein [imported...
8.0E-54 [243..414] [65..229]
CCU43_ARATH - Cyclin-U4-3 OS=Arabidopsis thaliana GN=CYCU4-3 PE=1 SV=1
3.0E-49 [230..407] [4..174]
gi|18766393 - gi|18766393|gb|AAL78998.1|AF465728_1 cyclin fold protein 1 variant a [Homo sapiens]
2.0E-44 [225..409] [38..260]
gi|15451434 - gi|15451434|dbj|BAB64521.1| hypothetical protein [Macaca fascicularis]
2.0E-43 [189..409] [13..245]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIKGDSPSS TNASSSPKST YSIQSDDKAN LGSGNVDIRT DNSQQDSNNR RDIVVVTRVA  60
   61 SEETLESQSS TSSMGIRPES SFNYEDASNQ ARVEMNNRVH GSNMNTINKY YPVRFPKNNE 120
  121 RQLSDTN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [128-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLNEKVQGTH TVQSSTQEDK ILDGDTSNSQ VTPSLNIAEF PTDKLLKMLT ALLTKIIKSN  60
   61 DRTAATNPSL TQEIENGRCL ALSDNEKKYL SPVLGFRGKH VPQIGLDQYF QRIQKYCPTT 120
  121 NDVFLSLLVY FDRISKRCNS VTTTPKTNTA KHESPSNESS LDKANRGADK MSACNSNENN 180
  181 E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.228 N/A N/A a.126.1 Serum albumin-like
View Download 0.218 N/A N/A a.118.8 TPR-like

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 5.56043783950774 bayes_pls_golite062009
cyclin-dependent protein kinase activity 3.56449795345173 bayes_pls_golite062009
protein kinase regulator activity 2.42298912398512 bayes_pls_golite062009
kinase regulator activity 2.38269740782712 bayes_pls_golite062009
binding 2.37916921859542 bayes_pls_golite062009
transcription regulator activity 2.35246308363499 bayes_pls_golite062009
nucleic acid binding 1.66282585660189 bayes_pls_golite062009
DNA binding 1.62111826122916 bayes_pls_golite062009
protein binding 1.37207701115974 bayes_pls_golite062009
transcription factor activity 0.942934833538458 bayes_pls_golite062009
protein kinase activity 0.936843200737436 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.790804751794544 bayes_pls_golite062009
kinase activity 0.76336575273867 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.681773164635831 bayes_pls_golite062009
hydrolase activity 0.639492478283697 bayes_pls_golite062009
transcription factor binding 0.578625558009429 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.553775750179295 bayes_pls_golite062009
protein serine/threonine kinase activity 0.529818399573297 bayes_pls_golite062009
enzyme regulator activity 0.461517963237846 bayes_pls_golite062009
kinase binding 0.288717702650258 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0259350481945262 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [309-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDSDDENTG VQRDSRAHPQ MFVMDSHNIH RLIIAGITVS TKFLSDFFYS NSRYSRVGGI  60
   61 SLQELNHLEL QFLVLCDFEL LISVNELQRY ADLLYRFWNN AKAQSQALVT GM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.39
Match: 1g3nC
Description: Viral cyclin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle