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View Structure Prediction Details

Protein: RPN3
Organism: Saccharomyces cerevisiae
Length: 523 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPN3.

Description E-value Query
Range		 Subject
Range
RPN3 - Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of th...
gi|151944731 - gi|151944731|gb|EDN62990.1| 26S proteasome regulatory module component [Saccharomyces cerevisiae YJM...
RPN3_YEAST - 26S proteasome regulatory subunit RPN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
 0.0 [1..523] [1..523]
PSD3A_ARATH - 26S proteasome non-ATPase regulatory subunit 3 homolog A OS=Arabidopsis thaliana GN=RPN3A PE=1 SV=3
 0.0 [9..513] [4..486]
PSMD3_TOBAC - Probable 26S proteasome non-ATPase regulatory subunit 3 OS=Nicotiana tabacum GN=21D7 PE=2 SV=1
 0.0 [9..513] [4..486]
PSMD3_ANOST - Probable 26S proteasome non-ATPase regulatory subunit 3 OS=Anopheles stephensi GN=DOXA2 PE=3 SV=1
 0.0 [2..513] [12..498]
PSMD3_DAUCA - Probable 26S proteasome non-ATPase regulatory subunit 3 OS=Daucus carota GN=21D7 PE=1 SV=2
 0.0 [9..513] [4..487]
PSD3_ANOGA - (O61470) Probable 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome subunit S3) (Diphen...
 0.0 [2..514] [10..495]

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Predicted Domain #1
Region A:
Residues: [1-109] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTAVMMDV DSSGVNDLHH SEKKYAEEDQ VQELLKVLNE ISKTTLTLDP RYIWRSLKDL  60
   61 SSLRNQELLN AETLCFTVNV LYPDSSSFKK NLLKFITSNH KSSVPGSAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.823 0.036 ubiquitin-dependent protein catabolic process a.118.8 TPR-like

Predicted Domain #2
Region A:
Residues: [110-315] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRNSYPASFY SVNTEKKTIE VTAEINCFMH LLVQLFLWDS KELEQLVEFN RKVVIPNLLC  60
   61 YYNLRSLNLI NAKLWFYIYL SHETLARSSE EINSDNQNII LRSTMMKFLK IASLKHDNET 120
  121 KAMLINLILR DFLNNGEVDS ASDFISKLEY PHTDVSSSLE ARYFFYLSKI NAIQLDYSTA 180
  181 NEYIIAAIRK APHNSKSLGF LQQSNK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.38
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.802999698299 bayes_pls_golite062009
binding 2.0556615145105 bayes_pls_golite062009
protein binding 1.85124014295385 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.499034250223658 bayes_pls_golite062009
small conjugating protein ligase activity 0.447205684237625 bayes_pls_golite062009
nucleic acid binding 0.437277381081288 bayes_pls_golite062009
transcription regulator activity 0.198767743012145 bayes_pls_golite062009
DNA binding 0.186035324819401 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [316-447] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHCCIQLLMG DIPELSFFHQ SNMQKSLLPY YHLTKAVKLG DLKKFTSTIT KYKQLLLKDD  60
   61 TYQLCVRLRS NVIKTGIRII SLTYKKISLR DICLKLNLDS EQTVEYMVSR AIRDGVIEAK 120
  121 INHEDGFIET TE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.38
Match: 1hz4A
Description: Transcription factor MalT domain III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.38230388954255 bayes_pls_golite062009
nucleic acid binding 3.38144578566524 bayes_pls_golite062009
DNA binding 3.30822066787723 bayes_pls_golite062009
binding 2.93590311675477 bayes_pls_golite062009
transcription factor activity 2.53517246325934 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
sequence-specific DNA binding 1.28622713424902 bayes_pls_golite062009
protein binding 1.09170941633583 bayes_pls_golite062009
transcription activator activity 1.08566311616647 bayes_pls_golite062009
transcription repressor activity 0.95491822926452 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42135864069093 bayes_pls_golite062009
structural molecule activity 0.272316540117209 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009
structural constituent of ribosome 0.0912115683429473 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [448-523] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLNIYDSEDP QQVFDERIKF ANQLHDEYLV SMRYPEDKKT QQNEKSENGE NDDDTLDGDL  60
   61 MDDMSDISDL DDLGFL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle