YRC Public Data Repository - Protein Structure Prediction

Protein:	NTF2
Organism:	Saccharomyces cerevisiae
Length:	125 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTF2.

Description	E-value	Query Range	Subject Range
gi\|25310685, gi\|... - gi\|9802547\|gb\|AAF99749.1\|AC004557_28 F17L21.10 [Arabidopsis thaliana], pir\|\|H86398 protein F17L21.10...	1.0E-40	[3..124]	[1..122]
gi\|223640932, gi... - gi\|241949743\|ref\|XP_002417594.1\| nuclear transport factor 2, putative [Candida dubliniensis CD36], g... NTF2_CANAX - Nuclear transport factor 2 OS=Candida albicans GN=NTF2 PE=3 SV=1	1.0E-40	[1..124]	[1..124]
ORFP:6054 - YER009W, Contig c425 25784-26161 gi\|190405570 - gi\|190405570\|gb\|EDV08837.1\| nuclear transport factor [Saccharomyces cerevisiae RM11-1a] NTF2_YEAST - Nuclear transport factor 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTF2 PE=1 SV=... NTF2 - Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to tr... gi\|151944717 - gi\|151944717\|gb\|EDN62976.1\| nuclear transport factor [Saccharomyces cerevisiae YJM789]	3.0E-40	[1..125]	[1..125]
gi\|125562321 - gi\|125562321\|gb\|EAZ07769.1\| hypothetical protein OsI_30022 [Oryza sativa Indica Group] NTF2_ORYSA - Nuclear transport factor 2 (NTF-2) - Oryza sativa (Rice) NTF2_ORYSJ - Nuclear transport factor 2 OS=Oryza sativa subsp. japonica GN=NTF2 PE=2 SV=1	3.0E-40	[3..123]	[1..121]
gi\|7246005, gi\|7... - gi\|7246008\|pdb\|1QMA\|D Chain D, Nuclear Transport Factor 2 (Ntf2) W7a Mutant, gi\|7246007\|pdb\|1QMA\|C C...	5.0E-40	[5..121]	[6..120]
tr\|M3X0F5\|M3X0F5... - Nuclear transport factor 2 OS=Felis catus GN=NUTF2 PE=4 SV=1 NUTF2 - nuclear transport factor 2 CCDS10848.1_1 - null ENSCJAT00000031145 - null gi\|149699240 - gi\|149699240\|ref\|XP_001498298.1\| PREDICTED: similar to Nuclear transport factor 2 (NTF-2) (Placental... HGNC:13722\|MIM:6... - transport factor 2 tr\|G1SQR7\|G1SQR7... - pep:novel chromosome:oryCun2:2:69386170:69386553:1 gene:ENSOCUG00000025641 transcript:ENSOCUT0000002... NTF2_BOVIN - Nuclear transport factor 2 OS=Bos taurus GN=NUTF2 PE=2 SV=1 tr\|G3HKX2\|G3HKX2... - Nuclear transport factor 2 OS=Cricetulus griseus GN=I79_011354 PE=4 SV=1 gi\|57087201, gi\|... - gi\|73957289\|ref\|XP_864539.1\| PREDICTED: similar to Nuclear transport factor 2 (NTF-2) isoform 3 [Can... gi\|90081342 - gi\|90081342\|dbj\|BAE90151.1\| unnamed protein product [Macaca fascicularis] NTF2_RAT - Nuclear transport factor 2 OS=Rattus norvegicus GN=Nutf2 PE=1 SV=1 gi\|190689363, gi... - gi\|190690725\|gb\|ACE87137.1\| nuclear transport factor 2 protein [synthetic construct], gi\|190689363\|g... NTF2_MOUSE - Nuclear transport factor 2 OS=Mus musculus GN=Nutf2 PE=1 SV=1 gi\|114663219, gi... - gi\|55644067\|ref\|XP_511042.1\| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes], gi\|1146632...	5.0E-40	[6..121]	[8..121]
NTF2_EMENI - Nuclear transport factor 2 OS=Emericella nidulans GN=ntf2 PE=3 SV=1 NTF2_EMENI - Nuclear transport factor 2 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 1...	1.0E-37	[4..125]	[3..125]

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Predicted Domain #1

Region A:
Residues: [1-125]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLDFNTLAQ NFTQFYYNQF DTDRSQLGNL YRNESMLTFE TSQLQGAKDI VEKLVSLPFQ  60
   61 KVQHRITTLD AQPASPNGDV LVMITGDLLI DEEQNPQRFS QVFHLIPDGN SYYVFNDIFR 120
  121 LNYSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	630.045757
Match:	1gy7A_
Description:	Nuclear transport factor-2 (NTF2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	3.2858716221712	bayes_pls_golite062009
nucleocytoplasmic transporter activity	2.57260151088345	bayes_pls_golite062009
binding	2.32562999055027	bayes_pls_golite062009
protein transmembrane transporter activity	2.22367856601071	bayes_pls_golite062009
transporter activity	1.80701285041353	bayes_pls_golite062009
substrate-specific transporter activity	1.33804818542017	bayes_pls_golite062009
structural constituent of nuclear pore	1.30758304562723	bayes_pls_golite062009
protein binding	1.24260899146543	bayes_pls_golite062009
transmembrane transporter activity	1.22102896992563	bayes_pls_golite062009
Ran GTPase binding	1.18290069522408	bayes_pls_golite062009
RNA binding	1.05240446104847	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.890150150408175	bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	0.79772386064313	bayes_pls_golite062009
macromolecule transmembrane transporter activity	0.79772386064313	bayes_pls_golite062009
nucleic acid binding	0.688410645367506	bayes_pls_golite062009
primary active transmembrane transporter activity	0.446562877324676	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.439519001457896	bayes_pls_golite062009
active transmembrane transporter activity	0.430285640125175	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: