YRC Public Data Repository - Protein Structure Prediction

Protein:	GRH1
Organism:	Saccharomyces cerevisiae
Length:	372 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GRH1.

Description	E-value	Query Range	Subject Range
GRH1 - Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65;... GRH1_YEAST - GRASP65 homolog protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GRH1 PE=1 SV=1 gi\|190404565 - gi\|190404565\|gb\|EDV07832.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	0.0	[1..372]	[1..372]
GORS1_RAT - Golgi reassembly-stacking protein 1 OS=Rattus norvegicus GN=Gorasp1 PE=1 SV=4	3.0E-91	[67..372]	[15..284]
GORS1_MOUSE - Golgi reassembly-stacking protein 1 OS=Mus musculus GN=Gorasp1 PE=1 SV=3	5.0E-89	[67..372]	[15..284]
GORASP1 - golgi reassembly stacking protein 1, 65kDa gi\|114586085 - gi\|114586085\|ref\|XP_001171913.1\| PREDICTED: Golgi reassembly stacking protein 1 [Pan troglodytes]	3.0E-84	[67..372]	[16..281]

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Predicted Domain #1

Region A:
Residues: [1-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRIAKNLVR TFEQSVQDTL ALSQDSSNLD AFFQSIPPNL LSAQLESPVD AVSEGVKHTN  60
   61 VNETLSGLRI VWVDEMQFQL QSFFDYIVGF NDDPVPVVSN QHGFSYPDYR RITSIFNEHC 120
  121 GRTLKVNIWS AKGGTFRDEY ISIISKESDD LDDVSLNHDE RRPSSGEAHQ FQALGFKVQW 180
  181 TPLIASTFTY HILNVNIPDG PAQSAGLIPD EDYIIGCQDG LLATGGETLL QDIVRSRANY 240
  241 DLVLYVYNKV SDCVRPITVH IGPDGRLGCN VGYGFLHRIP TVKH

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.70495852228344	bayes_pls_golite062009
protein binding	2.17099732113956	bayes_pls_golite062009
transporter activity	1.20918305129892	bayes_pls_golite062009
transmembrane transporter activity	1.08101408526167	bayes_pls_golite062009
substrate-specific transporter activity	0.768438717123608	bayes_pls_golite062009
cytoskeletal protein binding	0.717837655351774	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.557123581800701	bayes_pls_golite062009
active transmembrane transporter activity	0.260876923856991	bayes_pls_golite062009
protein transporter activity	0.184650447502837	bayes_pls_golite062009
signal transducer activity	0.0148882826722625	bayes_pls_golite062009
molecular transducer activity	0.0148882826722625	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [285-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPQQAQQQGQ DDNPVPVPVP VESETAFVPS AFTAPPVPTK KKSKNKKGTQ PLAMDDYFNE  60
   61 GRDKSSTAAK SAESDILAPP PQKQSSSD