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View Structure Prediction Details

Protein: PPM1
Organism: Saccharomyces cerevisiae
Length: 328 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPM1.

Description E-value Query
Range
Subject
Range
LCMT1_YEAST - Leucine carboxyl methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPM...
PPM1 - Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subuni...
4.0E-98 [1..328] [1..328]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-82 [2..326] [10..307]
LCMT1 - leucine carboxyl methyltransferase 1
gi|114661657 - gi|114661657|ref|XP_001164891.1| PREDICTED: leucine carboxyl methyltransferase 1 isoform 3 [Pan trog...
1.0E-81 [2..326] [23..320]
gi|42571301, gi|... - gi|42571301|ref|NP_973741.1| leucine carboxyl methyltransferase family protein [Arabidopsis thaliana...
6.0E-75 [4..326] [10..303]
SPBC19C7.08c - leucine carboxyl methyltransferase
TYW4_SCHPO - tRNA wybutosine-synthesizing protein 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppm...
1.0E-73 [2..326] [13..318]

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Predicted Domain #1
Region A:
Residues: [1-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERIIQQTDY DALSCKLAAI SVGYLPSSGL QRLSVDLSKK YTEWHRSYLI TLKKFSRRAF  60
   61 GKVDKAMRSS FPVMNYGTYL RTVGIDAAIL EFLVANEKVQ VVNLGCGSDL RMLPLLQMFP 120
  121 HLAYVDIDYN ESVELKNSIL RESEILRISL GLSKEDTAKS PFLIDQGRYK LAACDLNDIT 180
  181 ETTRLLDVCT KREIPTIVIS ECLLCYMHNN ESQLLINTIM SKFSHGLWIS YDPIGGSQPN 240
  241 DRFGAIMQSN LKESRN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein methyltransferase activity 4.65643463984431 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 4.4632173842967 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
N-methyltransferase activity 3.67177992319602 bayes_pls_golite062009
histone methyltransferase activity 3.4768933204909 bayes_pls_golite062009
arginine N-methyltransferase activity 2.91440420216458 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.91440420216458 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.45397942930513 bayes_pls_golite062009
transferase activity 2.22303238506686 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 2.07640017323617 bayes_pls_golite062009
DNA-methyltransferase activity 1.63765148226572 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.52139371235933 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 1.40758086578142 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
RNA methyltransferase activity 0.817509452491588 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
binding 0.348263200169904 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.328046788565125 bayes_pls_golite062009
rRNA methyltransferase activity 0.230719796976667 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [257-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEMPTLMTYN SKEKYASRWS AAPNVIVNDM WEIFNAQIPE SERKRLRSLQ FLDELEELKV  60
   61 MQTHYILMKA QW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.624 a.64.2 Bacteriocin AS-48
View Download 0.589 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.583 a.77.1 DEATH domain
View Download 0.425 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.392 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.386 a.2.3 Chaperone J-domain
View Download 0.375 a.64.1 Saposin
View Download 0.370 a.144.1 PABC (PABP) domain
View Download 0.362 a.17.1 p8-MTCP1
View Download 0.359 a.28.2 Colicin E immunity proteins
View Download 0.336 a.4.1 Homeodomain-like
View Download 0.318 a.65.1 Annexin
View Download 0.309 a.4.5 "Winged helix" DNA-binding domain
View Download 0.307 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.306 d.120.1 Cytochrome b5
View Download 0.279 a.5.6 Hypothetical protein MTH1615
View Download 0.277 a.3.1 Cytochrome c
View Download 0.274 a.157.1 Skp1 dimerisation domain-like
View Download 0.262 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.259 a.4.1 Homeodomain-like
View Download 0.257 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.254 a.4.5 "Winged helix" DNA-binding domain
View Download 0.241 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.229 a.3.1 Cytochrome c
View Download 0.227 a.64.1 Saposin
View Download 0.218 d.27.1 Ribosomal protein S16
View Download 0.215 a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.209 a.4.1 Homeodomain-like
View Download 0.207 d.74.2 C-terminal domain of arginine repressor
View Download 0.206 a.60.2 RuvA domain 2-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle