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View Structure Prediction Details

Protein: IRC3
Organism: Saccharomyces cerevisiae
Length: 689 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IRC3.

Description E-value Query
Range
Subject
Range
IRC3 - Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous...
gi|207346435 - gi|207346435|gb|EDZ72928.1| YDR332Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151942308 - gi|151942308|gb|EDN60664.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|190404727 - gi|190404727|gb|EDV07994.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
IRC3_YEAST - Putative ATP-dependent helicase IRC3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IRC...
0.0 [1..689] [1..689]
gi|157278092, gi... - gi|157278092|ref|NP_001098146.1| VASA [Oryzias latipes], gi|14522857|dbj|BAB61047.1| VASA [Oryzias l...
0.0 [3..418] [174..571]
gi|19482136 - gi|19482136|gb|AAL89410.1|AF461759_1 vasa-like protein [Danio rerio]
0.0 [3..418] [269..666]
gi|11990882 - gi|11990882|dbj|BAB19807.1| vasa [Oreochromis niloticus]
0.0 [3..417] [200..596]
RH52_ARATH - DEAD-box ATP-dependent RNA helicase 52 OS=Arabidopsis thaliana GN=RH52 PE=1 SV=1
0.0 [4..405] [140..532]

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Predicted Domain #1
Region A:
Residues: [1-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSTLATRLS TYSISLILQR IKIIKRCYSA PVLRDYQQDA IDACVNSIRQ GTKRIGVSLA  60
   61 TGGGKTVIFS NLINQLRQNY FKERQGNFKS LILVHRRELA LQATATLKKI FPDLKVHIEM 120
  121 GKYDCDIEDS DVIVASVQTL IRRLHKYDTN SVNLIIIDEA HHSVANSYRS ILDHFKASTA 180
  181 ETKIPVIGFS ATFERADKRA LSMVMDKIVY HRGILEMIDD KWLCEAKFTS VKIEADLSDV 240
  241 KSTADDFQLA PLSSLMNTKE INEVILKTYL HKKQEKSLKS TLLFGVDKAH VQSLHKLFKD 300
  301 NGINTDYVTS DTKQIERDNI IQKFKNGETE VLMNCGIFTE GTDMPNIDCI LLCRPTKSRS 360
  361 LLIQMIGRGL RLHHSKDHCH IIDFIGASSV GVVSAPTLLG IRSDDIEFDD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 132.228787
Match: 1fuuA_
Description: Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.837538244475264 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.420384345567397 bayes_pls_golite062009
pyrophosphatase activity 0.411077559082206 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.399864241228259 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.398496265411009 bayes_pls_golite062009
catalytic activity 0.234613562021476 bayes_pls_golite062009
hydrolase activity 0.216831145240405 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [411-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATVEDLKAIQ GEIIAKQQKI DERLRALFQT DEAAMENVTE RNSVADWIHS ANSVDLTLCS  60
   61 FDSFRNFTQS NNSYPSGKEF DEASEAVKEM ELLMNSQYPW VKFASNAWGL PLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.228787
Match: 1d9xA_
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.837538244475264 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.420384345567397 bayes_pls_golite062009
pyrophosphatase activity 0.411077559082206 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.399864241228259 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.398496265411009 bayes_pls_golite062009
catalytic activity 0.234613562021476 bayes_pls_golite062009
hydrolase activity 0.216831145240405 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [524-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKNHLRIYKE KSEDKLSMVY HLKMYRQLPC FITNKYADYV PKSIIKDANL WNVMSKVEKI  60
   61 INTLNSDLEG QTMQYQAISS KYSKWRQTVP TSKQRDFVFR KLKKVYGESS KDFIRLSLDD 120
  121 VTTYVNTKMT KGDASNLIFA SSLAPVYPLK SLLRILEYQK RRSFIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle